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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
APOE
Full Name:
Apolipoprotein E
Alias:
Apo-E
Type:
Lipid transport protein
Mass (Da):
36154
Number AA:
317
UniProt ID:
P02649
International Prot ID:
IPI00021842
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0005737
GO:0005794
Uniprot
OncoNet
Molecular Function:
GO:0001540
GO:0001871
GO:0005102
PhosphoSite+
KinaseNET
Biological Process:
GO:0000302
GO:0001936
GO:0001937
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T36
E
P
E
L
R
Q
Q
T
E
W
Q
S
G
Q
R
Site 2
Y54
A
L
G
R
F
W
D
Y
L
R
W
V
Q
T
L
Site 3
T60
D
Y
L
R
W
V
Q
T
L
S
E
Q
V
Q
E
Site 4
S72
V
Q
E
E
L
L
S
S
Q
V
T
Q
E
L
R
Site 5
Y92
T
M
K
E
L
K
A
Y
K
S
E
L
E
E
Q
Site 6
S94
K
E
L
K
A
Y
K
S
E
L
E
E
Q
L
T
Site 7
T101
S
E
L
E
E
Q
L
T
P
V
A
E
E
T
R
Site 8
S112
E
E
T
R
A
R
L
S
K
E
L
Q
A
A
Q
Site 9
S147
V
Q
A
M
L
G
Q
S
T
E
E
L
R
V
R
Site 10
S157
E
L
R
V
R
L
A
S
H
L
R
K
L
R
K
Site 11
Y180
L
Q
K
R
L
A
V
Y
Q
A
G
A
R
E
G
Site 12
S193
E
G
A
E
R
G
L
S
A
I
R
E
R
L
G
Site 13
T212
Q
G
R
V
R
A
A
T
V
G
S
L
A
G
Q
Site 14
S241
A
R
M
E
E
M
G
S
R
T
R
D
R
L
D
Site 15
S281
A
F
Q
A
R
L
K
S
W
F
E
P
L
V
E
Site 16
S314
T
S
A
A
P
V
P
S
D
N
H
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation