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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AFP
Full Name:
Alpha-fetoprotein
Alias:
Alpha-1-fetoprotein;Alpha-fetoglobulin
Type:
Mass (Da):
68678
Number AA:
609
UniProt ID:
P02771
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Alpha-fetoprotein (425-433, human) peptide - Powder PE-01AEV95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AEV95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
L
N
F
T
E
S
R
T
L
H
R
N
E
Y
G
Site 2
Y26
R
T
L
H
R
N
E
Y
G
I
A
S
I
L
D
Site 3
S30
R
N
E
Y
G
I
A
S
I
L
D
S
Y
Q
C
Site 4
Y60
Q
F
V
Q
E
A
T
Y
K
E
V
S
K
M
V
Site 5
T72
K
M
V
K
D
A
L
T
A
I
E
K
P
T
G
Site 6
S84
P
T
G
D
E
Q
S
S
G
C
L
E
N
Q
L
Site 7
Y108
E
K
E
I
L
E
K
Y
G
H
S
D
C
C
S
Site 8
S111
I
L
E
K
Y
G
H
S
D
C
C
S
Q
S
E
Site 9
S115
Y
G
H
S
D
C
C
S
Q
S
E
E
G
R
H
Site 10
S135
H
K
K
P
T
P
A
S
I
P
L
F
Q
V
P
Site 11
S147
Q
V
P
E
P
V
T
S
C
E
A
Y
E
E
D
Site 12
Y151
P
V
T
S
C
E
A
Y
E
E
D
R
E
T
F
Site 13
Y164
T
F
M
N
K
F
I
Y
E
I
A
R
R
H
P
Site 14
T204
N
A
V
E
C
F
Q
T
K
A
A
T
V
T
K
Site 15
S216
V
T
K
E
L
R
E
S
S
L
L
N
Q
H
A
Site 16
S217
T
K
E
L
R
E
S
S
L
L
N
Q
H
A
C
Site 17
T234
M
K
N
F
G
T
R
T
F
Q
A
I
T
V
T
Site 18
S244
A
I
T
V
T
K
L
S
Q
K
F
T
K
V
N
Site 19
T248
T
K
L
S
Q
K
F
T
K
V
N
F
T
E
I
Site 20
Y287
D
G
E
K
I
M
S
Y
I
C
S
Q
Q
D
T
Site 21
S290
K
I
M
S
Y
I
C
S
Q
Q
D
T
L
S
N
Site 22
T294
Y
I
C
S
Q
Q
D
T
L
S
N
K
I
T
E
Site 23
T300
D
T
L
S
N
K
I
T
E
C
C
K
L
T
T
Site 24
T307
T
E
C
C
K
L
T
T
L
E
R
G
Q
C
I
Site 25
S327
D
E
K
P
E
G
L
S
P
N
L
N
R
F
L
Site 26
S353
E
K
N
I
F
L
A
S
F
V
H
E
Y
S
R
Site 27
Y358
L
A
S
F
V
H
E
Y
S
R
R
H
P
Q
L
Site 28
S359
A
S
F
V
H
E
Y
S
R
R
H
P
Q
L
A
Site 29
S368
R
H
P
Q
L
A
V
S
V
I
L
R
V
A
K
Site 30
Y377
I
L
R
V
A
K
G
Y
Q
E
L
L
E
K
C
Site 31
T387
L
L
E
K
C
F
Q
T
E
N
P
L
E
C
Q
Site 32
Y404
G
E
E
E
L
Q
K
Y
I
Q
E
S
Q
A
L
Site 33
S445
K
A
P
Q
L
T
S
S
E
L
M
A
I
T
R
Site 34
Y505
G
Q
C
C
T
S
S
Y
A
N
R
R
P
C
F
Site 35
S513
A
N
R
R
P
C
F
S
S
L
V
V
D
E
T
Site 36
S514
N
R
R
P
C
F
S
S
L
V
V
D
E
T
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation