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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
F11
Full Name:
Coagulation factor XI
Alias:
coagulation factor XI; coagulation factor XIa heavy chain/light chain; FA11; FXI; plasma thromboplastin antecedent; PTA
Type:
Protease; EC 3.4.21.27
Mass (Da):
70110
Number AA:
UniProt ID:
P03951
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0008201
GO:0004252
PhosphoSite+
KinaseNET
Biological Process:
GO:0007596
GO:0031639
GO:0051919
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
F
I
L
F
T
S
V
S
G
E
C
V
T
Q
L
Site 2
T22
S
V
S
G
E
C
V
T
Q
L
L
K
D
T
C
Site 3
T37
F
E
G
G
D
I
T
T
V
F
T
P
S
A
K
Site 4
T40
G
D
I
T
T
V
F
T
P
S
A
K
Y
C
Q
Site 5
T60
H
P
R
C
L
L
F
T
F
T
A
E
S
P
S
Site 6
T62
R
C
L
L
F
T
F
T
A
E
S
P
S
E
D
Site 7
S65
L
F
T
F
T
A
E
S
P
S
E
D
P
T
R
Site 8
S67
T
F
T
A
E
S
P
S
E
D
P
T
R
W
F
Site 9
T71
E
S
P
S
E
D
P
T
R
W
F
T
C
V
L
Site 10
T75
E
D
P
T
R
W
F
T
C
V
L
K
D
S
V
Site 11
T85
L
K
D
S
V
T
E
T
L
P
R
V
N
R
T
Site 12
T92
T
L
P
R
V
N
R
T
A
A
I
S
G
Y
S
Site 13
S96
V
N
R
T
A
A
I
S
G
Y
S
F
K
Q
C
Site 14
S99
T
A
A
I
S
G
Y
S
F
K
Q
C
S
H
Q
Site 15
Y115
S
A
C
N
K
D
I
Y
V
D
L
D
M
K
G
Site 16
Y125
L
D
M
K
G
I
N
Y
N
S
S
V
A
K
S
Site 17
S127
M
K
G
I
N
Y
N
S
S
V
A
K
S
A
Q
Site 18
S128
K
G
I
N
Y
N
S
S
V
A
K
S
A
Q
E
Site 19
S132
Y
N
S
S
V
A
K
S
A
Q
E
C
Q
E
R
Site 20
T172
C
L
L
K
H
T
Q
T
G
T
P
T
R
I
T
Site 21
T174
L
K
H
T
Q
T
G
T
P
T
R
I
T
K
L
Site 22
T179
T
G
T
P
T
R
I
T
K
L
D
K
V
V
S
Site 23
S186
T
K
L
D
K
V
V
S
G
F
S
L
K
S
C
Site 24
S250
S
Q
E
W
P
K
E
S
Q
R
N
L
C
L
L
Site 25
T259
R
N
L
C
L
L
K
T
S
E
S
G
L
P
S
Site 26
S260
N
L
C
L
L
K
T
S
E
S
G
L
P
S
T
Site 27
S262
C
L
L
K
T
S
E
S
G
L
P
S
T
R
I
Site 28
S266
T
S
E
S
G
L
P
S
T
R
I
K
K
S
K
Site 29
T267
S
E
S
G
L
P
S
T
R
I
K
K
S
K
A
Site 30
S272
P
S
T
R
I
K
K
S
K
A
L
S
G
F
S
Site 31
S276
I
K
K
S
K
A
L
S
G
F
S
L
Q
S
C
Site 32
S279
S
K
A
L
S
G
F
S
L
Q
S
C
R
H
S
Site 33
S286
S
L
Q
S
C
R
H
S
I
P
V
F
C
H
S
Site 34
T299
H
S
S
F
Y
H
D
T
D
F
L
G
E
E
L
Site 35
T331
A
V
R
C
Q
F
F
T
Y
T
P
A
Q
A
S
Site 36
Y347
N
E
G
K
G
K
C
Y
L
K
L
S
S
N
G
Site 37
S351
G
K
C
Y
L
K
L
S
S
N
G
S
P
T
K
Site 38
S352
K
C
Y
L
K
L
S
S
N
G
S
P
T
K
I
Site 39
S355
L
K
L
S
S
N
G
S
P
T
K
I
L
H
G
Site 40
Y369
G
R
G
G
I
S
G
Y
T
L
R
L
C
K
M
Site 41
T370
R
G
G
I
S
G
Y
T
L
R
L
C
K
M
D
Site 42
T392
K
P
R
I
V
G
G
T
A
S
V
R
G
E
W
Site 43
S394
R
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Site 44
T404
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
T
Site 45
T407
P
W
Q
V
T
L
H
T
T
S
P
T
Q
R
H
Site 46
S409
Q
V
T
L
H
T
T
S
P
T
Q
R
H
L
C
Site 47
T411
T
L
H
T
T
S
P
T
Q
R
H
L
C
G
G
Site 48
Y445
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
S
Site 49
S446
P
K
I
L
R
V
Y
S
G
I
L
N
Q
S
E
Site 50
S459
S
E
I
K
E
D
T
S
F
F
G
V
Q
E
I
Site 51
Y472
E
I
I
I
H
D
Q
Y
K
M
A
E
S
G
Y
Site 52
T489
A
L
L
K
L
E
T
T
V
N
Y
T
D
S
Q
Site 53
S495
T
T
V
N
Y
T
D
S
Q
R
P
I
C
L
P
Site 54
Y511
K
G
D
R
N
V
I
Y
T
D
C
W
V
T
G
Site 55
S575
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
Site 56
S580
G
D
S
G
G
P
L
S
C
K
H
N
E
V
W
Site 57
Y608
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
Site 58
T609
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation