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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLKB1
Full Name:
Plasma kallikrein
Alias:
Fletcher factor;Kininogenin;Plasma prekallikrein
Type:
Mass (Da):
71370
Number AA:
638
UniProt ID:
P03952
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S38
F
R
G
G
D
V
A
S
M
Y
T
P
N
A
Q
Site 2
Y40
G
G
D
V
A
S
M
Y
T
P
N
A
Q
Y
C
Site 3
T41
G
D
V
A
S
M
Y
T
P
N
A
Q
Y
C
Q
Site 4
T86
L
K
D
S
V
T
G
T
L
P
K
V
H
R
T
Site 5
T93
T
L
P
K
V
H
R
T
G
A
V
S
G
H
S
Site 6
S97
V
H
R
T
G
A
V
S
G
H
S
L
K
Q
C
Site 7
S100
T
G
A
V
S
G
H
S
L
K
Q
C
G
H
Q
Site 8
Y116
S
A
C
H
R
D
I
Y
K
G
V
D
M
R
G
Site 9
S129
R
G
V
N
F
N
V
S
K
V
S
S
V
E
E
Site 10
S133
F
N
V
S
K
V
S
S
V
E
E
C
Q
K
R
Site 11
T156
F
F
S
Y
A
T
Q
T
F
H
K
A
E
Y
R
Site 12
Y170
R
N
N
C
L
L
K
Y
S
P
G
G
T
P
T
Site 13
S171
N
N
C
L
L
K
Y
S
P
G
G
T
P
T
A
Site 14
T177
Y
S
P
G
G
T
P
T
A
I
K
V
L
S
N
Site 15
S187
K
V
L
S
N
V
E
S
G
F
S
L
K
P
C
Site 16
S190
S
N
V
E
S
G
F
S
L
K
P
C
A
L
S
Site 17
T260
R
N
V
C
L
L
K
T
S
E
S
G
T
P
S
Site 18
S261
N
V
C
L
L
K
T
S
E
S
G
T
P
S
S
Site 19
S263
C
L
L
K
T
S
E
S
G
T
P
S
S
S
T
Site 20
T265
L
K
T
S
E
S
G
T
P
S
S
S
T
P
Q
Site 21
S267
T
S
E
S
G
T
P
S
S
S
T
P
Q
E
N
Site 22
S268
S
E
S
G
T
P
S
S
S
T
P
Q
E
N
T
Site 23
S269
E
S
G
T
P
S
S
S
T
P
Q
E
N
T
I
Site 24
T270
S
G
T
P
S
S
S
T
P
Q
E
N
T
I
S
Site 25
T275
S
S
T
P
Q
E
N
T
I
S
G
Y
S
L
L
Site 26
S277
T
P
Q
E
N
T
I
S
G
Y
S
L
L
T
C
Site 27
T283
I
S
G
Y
S
L
L
T
C
K
R
T
L
P
E
Site 28
T287
S
L
L
T
C
K
R
T
L
P
E
P
C
H
S
Site 29
S294
T
L
P
E
P
C
H
S
K
I
Y
P
G
V
D
Site 30
Y297
E
P
C
H
S
K
I
Y
P
G
V
D
F
G
G
Site 31
S352
C
K
C
F
L
R
L
S
M
D
G
S
P
T
R
Site 32
S356
L
R
L
S
M
D
G
S
P
T
R
I
A
Y
G
Site 33
Y362
G
S
P
T
R
I
A
Y
G
T
Q
G
S
S
G
Site 34
T364
P
T
R
I
A
Y
G
T
Q
G
S
S
G
Y
S
Site 35
S367
I
A
Y
G
T
Q
G
S
S
G
Y
S
L
R
L
Site 36
S371
T
Q
G
S
S
G
Y
S
L
R
L
C
N
T
G
Site 37
T377
Y
S
L
R
L
C
N
T
G
D
N
S
V
C
T
Site 38
S381
L
C
N
T
G
D
N
S
V
C
T
T
K
T
S
Site 39
T384
T
G
D
N
S
V
C
T
T
K
T
S
T
R
I
Site 40
T385
G
D
N
S
V
C
T
T
K
T
S
T
R
I
V
Site 41
T387
N
S
V
C
T
T
K
T
S
T
R
I
V
G
G
Site 42
S388
S
V
C
T
T
K
T
S
T
R
I
V
G
G
T
Site 43
T395
S
T
R
I
V
G
G
T
N
S
S
W
G
E
W
Site 44
S407
G
E
W
P
W
Q
V
S
L
Q
V
K
L
T
A
Site 45
S449
Q
D
V
W
R
I
Y
S
G
I
L
N
L
S
D
Site 46
S455
Y
S
G
I
L
N
L
S
D
I
T
K
D
T
P
Site 47
T461
L
S
D
I
T
K
D
T
P
F
S
Q
I
K
E
Site 48
Y475
E
I
I
I
H
Q
N
Y
K
V
S
E
G
N
H
Site 49
S506
Q
K
P
I
C
L
P
S
K
G
D
T
S
T
I
Site 50
T510
C
L
P
S
K
G
D
T
S
T
I
Y
T
N
C
Site 51
Y514
K
G
D
T
S
T
I
Y
T
N
C
W
V
T
G
Site 52
Y555
C
Q
K
R
Y
Q
D
Y
K
I
T
Q
R
M
V
Site 53
Y611
R
R
E
Q
P
G
V
Y
T
K
V
A
E
Y
M
Site 54
T625
M
D
W
I
L
E
K
T
Q
S
S
D
G
K
A
Site 55
S627
W
I
L
E
K
T
Q
S
S
D
G
K
A
Q
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation