KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
C4BPA
Full Name:
C4b-binding protein alpha chain
Alias:
Proline-rich protein
Type:
Mass (Da):
67033
Number AA:
597
UniProt ID:
P04003
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
H
P
P
K
T
P
S
G
A
L
H
R
Site 2
T65
F
A
A
P
M
D
I
T
L
T
E
T
R
F
K
Site 3
T67
A
P
M
D
I
T
L
T
E
T
R
F
K
T
G
Site 4
T73
L
T
E
T
R
F
K
T
G
T
T
L
K
Y
T
Site 5
T75
E
T
R
F
K
T
G
T
T
L
K
Y
T
C
L
Site 6
Y79
K
T
G
T
T
L
K
Y
T
C
L
P
G
Y
V
Site 7
T80
T
G
T
T
L
K
Y
T
C
L
P
G
Y
V
R
Site 8
Y85
K
Y
T
C
L
P
G
Y
V
R
S
H
S
T
Q
Site 9
S88
C
L
P
G
Y
V
R
S
H
S
T
Q
T
L
T
Site 10
S90
P
G
Y
V
R
S
H
S
T
Q
T
L
T
C
N
Site 11
T95
S
H
S
T
Q
T
L
T
C
N
S
D
G
E
W
Site 12
T128
N
G
Q
V
E
I
K
T
D
L
S
F
G
S
Q
Site 13
S131
V
E
I
K
T
D
L
S
F
G
S
Q
I
E
F
Site 14
S134
K
T
D
L
S
F
G
S
Q
I
E
F
S
C
S
Site 15
S187
D
I
R
N
G
R
H
S
G
E
E
N
F
Y
A
Site 16
Y193
H
S
G
E
E
N
F
Y
A
Y
G
F
S
V
T
Site 17
S202
Y
G
F
S
V
T
Y
S
C
D
P
R
F
S
L
Site 18
S208
Y
S
C
D
P
R
F
S
L
L
G
H
A
S
I
Site 19
T218
G
H
A
S
I
S
C
T
V
E
N
E
T
I
G
Site 20
S230
T
I
G
V
W
R
P
S
P
P
T
C
E
K
I
Site 21
T233
V
W
R
P
S
P
P
T
C
E
K
I
T
C
R
Site 22
S245
T
C
R
K
P
D
V
S
H
G
E
M
V
S
G
Site 23
S251
V
S
H
G
E
M
V
S
G
F
G
P
I
Y
N
Site 24
Y259
G
F
G
P
I
Y
N
Y
K
D
T
I
V
F
K
Site 25
S290
A
D
S
K
W
N
P
S
P
P
A
C
E
P
N
Site 26
S298
P
P
A
C
E
P
N
S
C
I
N
L
P
D
I
Site 27
S309
L
P
D
I
P
H
A
S
W
E
T
Y
P
R
P
Site 28
Y313
P
H
A
S
W
E
T
Y
P
R
P
T
K
E
D
Site 29
T317
W
E
T
Y
P
R
P
T
K
E
D
V
Y
V
V
Site 30
Y322
R
P
T
K
E
D
V
Y
V
V
G
T
V
L
R
Site 31
Y330
V
V
G
T
V
L
R
Y
R
C
H
P
G
Y
K
Site 32
Y336
R
Y
R
C
H
P
G
Y
K
P
T
T
D
E
P
Site 33
T340
H
P
G
Y
K
P
T
T
D
E
P
T
T
V
I
Site 34
T345
P
T
T
D
E
P
T
T
V
I
C
Q
K
N
L
Site 35
Y357
K
N
L
R
W
T
P
Y
Q
G
C
E
A
L
C
Site 36
T376
K
L
N
N
G
E
I
T
Q
H
R
K
S
R
P
Site 37
Y389
R
P
A
N
H
C
V
Y
F
Y
G
D
E
I
S
Site 38
Y391
A
N
H
C
V
Y
F
Y
G
D
E
I
S
F
S
Site 39
S398
Y
G
D
E
I
S
F
S
C
H
E
T
S
R
F
Site 40
T414
A
I
C
Q
G
D
G
T
W
S
P
R
T
P
S
Site 41
S416
C
Q
G
D
G
T
W
S
P
R
T
P
S
C
G
Site 42
T419
D
G
T
W
S
P
R
T
P
S
C
G
D
I
C
Site 43
Y437
P
K
I
A
H
G
H
Y
K
Q
S
S
S
Y
S
Site 44
S440
A
H
G
H
Y
K
Q
S
S
S
Y
S
F
F
K
Site 45
S441
H
G
H
Y
K
Q
S
S
S
Y
S
F
F
K
E
Site 46
S442
G
H
Y
K
Q
S
S
S
Y
S
F
F
K
E
E
Site 47
S444
Y
K
Q
S
S
S
Y
S
F
F
K
E
E
I
I
Site 48
Y452
F
F
K
E
E
I
I
Y
E
C
D
K
G
Y
I
Site 49
Y458
I
Y
E
C
D
K
G
Y
I
L
V
G
Q
A
K
Site 50
S467
L
V
G
Q
A
K
L
S
C
S
Y
S
H
W
S
Site 51
S469
G
Q
A
K
L
S
C
S
Y
S
H
W
S
A
P
Site 52
S471
A
K
L
S
C
S
Y
S
H
W
S
A
P
A
P
Site 53
S495
E
L
V
N
G
R
L
S
V
D
K
D
Q
Y
V
Site 54
Y501
L
S
V
D
K
D
Q
Y
V
E
P
E
N
V
T
Site 55
Y515
T
I
Q
C
D
S
G
Y
G
V
V
G
P
Q
S
Site 56
S522
Y
G
V
V
G
P
Q
S
I
T
C
S
G
N
R
Site 57
T530
I
T
C
S
G
N
R
T
W
Y
P
E
V
P
K
Site 58
Y532
C
S
G
N
R
T
W
Y
P
E
V
P
K
C
E
Site 59
T542
V
P
K
C
E
W
E
T
P
E
G
C
E
Q
V
Site 60
T551
E
G
C
E
Q
V
L
T
G
K
R
L
M
Q
C
Site 61
S587
Q
L
E
L
Q
R
D
S
A
R
Q
S
T
L
D
Site 62
S591
Q
R
D
S
A
R
Q
S
T
L
D
K
E
L
_
Site 63
T592
R
D
S
A
R
Q
S
T
L
D
K
E
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation