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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DNTT
Full Name:
DNA nucleotidylexotransferase
Alias:
Deoxynucleotidyltransferase, terminal; EC 2.7.7.31; Nucleosidetriphosphate:DNA deoxynucleotidylexotransferase; Nucleosidetriphosphate;DNA deoxynucleotidylexotransferase; TDT; Terminal addition enzyme; Terminal deoxynucleotidyltransferase; Terminal deoxyribonucleotidyltransferase; Terminal transferase
Type:
EC 2.7.7.31; Transferase
Mass (Da):
58437
Number AA:
509
UniProt ID:
P04053
International Prot ID:
IPI00219676
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003912
GO:0003887
PhosphoSite+
KinaseNET
Biological Process:
GO:0006304
GO:0006260
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
D
P
P
R
A
S
H
L
S
P
R
K
K
Site 2
S10
P
P
R
A
S
H
L
S
P
R
K
K
R
P
R
Site 3
T19
R
K
K
R
P
R
Q
T
G
A
L
M
A
S
S
Site 4
S26
T
G
A
L
M
A
S
S
P
Q
D
I
K
F
Q
Site 5
T46
I
L
E
K
K
M
G
T
T
R
R
A
F
L
M
Site 6
S68
F
R
V
E
N
E
L
S
D
S
V
T
H
I
V
Site 7
S70
V
E
N
E
L
S
D
S
V
T
H
I
V
A
E
Site 8
T72
N
E
L
S
D
S
V
T
H
I
V
A
E
N
N
Site 9
S80
H
I
V
A
E
N
N
S
G
S
D
V
L
E
W
Site 10
S82
V
A
E
N
N
S
G
S
D
V
L
E
W
L
Q
Site 11
S97
A
Q
K
V
Q
V
S
S
Q
P
E
L
L
D
V
Site 12
Y131
Q
L
V
V
R
R
D
Y
S
D
S
T
N
P
G
Site 13
S132
L
V
V
R
R
D
Y
S
D
S
T
N
P
G
P
Site 14
S134
V
R
R
D
Y
S
D
S
T
N
P
G
P
P
K
Site 15
T135
R
R
D
Y
S
D
S
T
N
P
G
P
P
K
T
Site 16
T142
T
N
P
G
P
P
K
T
P
P
I
A
V
Q
K
Site 17
S151
P
I
A
V
Q
K
I
S
Q
Y
A
C
Q
R
R
Site 18
S187
E
F
R
E
N
E
D
S
C
V
T
F
M
R
A
Site 19
T190
E
N
E
D
S
C
V
T
F
M
R
A
A
S
V
Site 20
S196
V
T
F
M
R
A
A
S
V
L
K
S
L
P
F
Site 21
S234
E
I
I
E
D
G
E
S
S
E
V
K
A
V
L
Site 22
Y246
A
V
L
N
D
E
R
Y
Q
S
F
K
L
F
T
Site 23
S248
L
N
D
E
R
Y
Q
S
F
K
L
F
T
S
V
Site 24
T262
V
F
G
V
G
L
K
T
S
E
K
W
F
R
M
Site 25
S263
F
G
V
G
L
K
T
S
E
K
W
F
R
M
G
Site 26
T273
W
F
R
M
G
F
R
T
L
S
K
V
R
S
D
Site 27
S275
R
M
G
F
R
T
L
S
K
V
R
S
D
K
S
Site 28
S279
R
T
L
S
K
V
R
S
D
K
S
L
K
F
T
Site 29
S282
S
K
V
R
S
D
K
S
L
K
F
T
R
M
Q
Site 30
T286
S
D
K
S
L
K
F
T
R
M
Q
K
A
G
F
Site 31
T349
H
D
V
D
F
L
I
T
S
P
G
S
T
E
D
Site 32
S350
D
V
D
F
L
I
T
S
P
G
S
T
E
D
E
Site 33
T354
L
I
T
S
P
G
S
T
E
D
E
E
Q
L
L
Site 34
Y376
E
K
K
G
L
L
L
Y
Y
D
L
V
E
S
T
Site 35
S382
L
Y
Y
D
L
V
E
S
T
F
E
K
L
R
L
Site 36
T383
Y
Y
D
L
V
E
S
T
F
E
K
L
R
L
P
Site 37
S391
F
E
K
L
R
L
P
S
R
K
V
D
A
L
D
Site 38
S416
L
P
R
Q
R
V
D
S
D
Q
S
S
W
Q
E
Site 39
S420
R
V
D
S
D
Q
S
S
W
Q
E
G
K
T
W
Site 40
T426
S
S
W
Q
E
G
K
T
W
K
A
I
R
V
D
Site 41
S452
A
L
L
G
W
T
G
S
R
Q
F
E
R
D
L
Site 42
Y462
F
E
R
D
L
R
R
Y
A
T
H
E
R
K
M
Site 43
T464
R
D
L
R
R
Y
A
T
H
E
R
K
M
I
L
Site 44
Y477
I
L
D
N
H
A
L
Y
D
K
T
K
R
I
F
Site 45
T480
N
H
A
L
Y
D
K
T
K
R
I
F
L
K
A
Site 46
S489
R
I
F
L
K
A
E
S
E
E
E
I
F
A
H
Site 47
Y501
F
A
H
L
G
L
D
Y
I
E
P
W
E
R
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation