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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GBA
Full Name:
Glucosylceramidase
Alias:
Acid beta-glucosidase; Alglucerase; Beta-glucocerebrosidase; D-glucosyl-N-acylsphingosine glucohydrolase; GBA1; GLCM; GLUC; Glucosidase, beta; Gucosylceramidase; Imiglucerase
Type:
Lipid Metabolism - sphingolipid; EC 3.2.1.45; Glycan Metabolism - other glycan degradation; Hydrolase
Mass (Da):
59716
Number AA:
536
UniProt ID:
P04062
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005764
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0043169
GO:0004348
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0005975
GO:0007040
GO:0006665
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
E
E
C
P
K
P
L
S
R
V
S
I
M
A
G
Site 2
T75
P
T
F
P
A
L
G
T
F
S
R
Y
E
S
T
Site 3
S77
F
P
A
L
G
T
F
S
R
Y
E
S
T
R
S
Site 4
Y79
A
L
G
T
F
S
R
Y
E
S
T
R
S
G
R
Site 5
S81
G
T
F
S
R
Y
E
S
T
R
S
G
R
R
M
Site 6
S84
S
R
Y
E
S
T
R
S
G
R
R
M
E
L
S
Site 7
S91
S
G
R
R
M
E
L
S
M
G
P
I
Q
A
N
Site 8
T107
T
G
T
G
L
L
L
T
L
Q
P
E
Q
K
F
Site 9
S146
A
Q
N
L
L
L
K
S
Y
F
S
E
E
G
I
Site 10
Y147
Q
N
L
L
L
K
S
Y
F
S
E
E
G
I
G
Site 11
S149
L
L
L
K
S
Y
F
S
E
E
G
I
G
Y
N
Site 12
Y172
C
D
F
S
I
R
T
Y
T
Y
A
D
T
P
D
Site 13
T173
D
F
S
I
R
T
Y
T
Y
A
D
T
P
D
D
Site 14
T177
R
T
Y
T
Y
A
D
T
P
D
D
F
Q
L
H
Site 15
T193
F
S
L
P
E
E
D
T
K
L
K
I
P
L
I
Site 16
S212
Q
L
A
Q
R
P
V
S
L
L
A
S
P
W
T
Site 17
S216
R
P
V
S
L
L
A
S
P
W
T
S
P
T
W
Site 18
S220
L
L
A
S
P
W
T
S
P
T
W
L
K
T
N
Site 19
T226
T
S
P
T
W
L
K
T
N
G
A
V
N
G
K
Site 20
S235
G
A
V
N
G
K
G
S
L
K
G
Q
P
G
D
Site 21
Y244
K
G
Q
P
G
D
I
Y
H
Q
T
W
A
R
Y
Site 22
Y251
Y
H
Q
T
W
A
R
Y
F
V
K
F
L
D
A
Site 23
S276
V
T
A
E
N
E
P
S
A
G
L
L
S
G
Y
Site 24
T291
P
F
Q
C
L
G
F
T
P
E
H
Q
R
D
F
Site 25
T306
I
A
R
D
L
G
P
T
L
A
N
S
T
H
H
Site 26
T311
G
P
T
L
A
N
S
T
H
H
N
V
R
L
L
Site 27
Y343
T
D
P
E
A
A
K
Y
V
H
G
I
A
V
H
Site 28
T366
A
K
A
T
L
G
E
T
H
R
L
F
P
N
T
Site 29
T373
T
H
R
L
F
P
N
T
M
L
F
A
S
E
A
Site 30
S390
G
S
K
F
W
E
Q
S
V
R
L
G
S
W
D
Site 31
S395
E
Q
S
V
R
L
G
S
W
D
R
G
M
Q
Y
Site 32
Y402
S
W
D
R
G
M
Q
Y
S
H
S
I
I
T
N
Site 33
S405
R
G
M
Q
Y
S
H
S
I
I
T
N
L
L
Y
Site 34
Y412
S
I
I
T
N
L
L
Y
H
V
V
G
W
T
D
Site 35
T446
S
P
I
I
V
D
I
T
K
D
T
F
Y
K
Q
Site 36
Y451
D
I
T
K
D
T
F
Y
K
Q
P
M
F
Y
H
Site 37
S470
S
K
F
I
P
E
G
S
Q
R
V
G
L
V
A
Site 38
S478
Q
R
V
G
L
V
A
S
Q
K
N
D
L
D
A
Site 39
T510
S
S
K
D
V
P
L
T
I
K
D
P
A
V
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation