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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LCAT
Full Name:
Phosphatidylcholine-sterol acyltransferase
Alias:
Lecithin-cholesterol acyltransferase;Phospholipid-cholesterol acyltransferase
Type:
Enzyme
Mass (Da):
49578
Number AA:
440
UniProt ID:
P04180
International Prot ID:
IPI00022331
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0034364
Uniprot
OncoNet
Molecular Function:
GO:0034186
GO:0004607
PhosphoSite+
KinaseNET
Biological Process:
GO:0034435
GO:0042632
GO:0008203
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T36
N
V
L
F
P
P
H
T
T
P
K
A
E
L
S
Site 2
T37
V
L
F
P
P
H
T
T
P
K
A
E
L
S
N
Site 3
S43
T
T
P
K
A
E
L
S
N
H
T
R
P
V
I
Site 4
Y107
I
D
N
T
R
V
V
Y
N
R
S
S
G
L
V
Site 5
S111
R
V
V
Y
N
R
S
S
G
L
V
S
N
A
P
Site 6
S115
N
R
S
S
G
L
V
S
N
A
P
G
V
Q
I
Site 7
T130
R
V
P
G
F
G
K
T
Y
S
V
E
Y
L
D
Site 8
S132
P
G
F
G
K
T
Y
S
V
E
Y
L
D
S
S
Site 9
Y135
G
K
T
Y
S
V
E
Y
L
D
S
S
K
L
A
Site 10
S138
Y
S
V
E
Y
L
D
S
S
K
L
A
G
Y
L
Site 11
S139
S
V
E
Y
L
D
S
S
K
L
A
G
Y
L
H
Site 12
Y157
Q
N
L
V
N
N
G
Y
V
R
D
E
T
V
R
Site 13
T162
N
G
Y
V
R
D
E
T
V
R
A
A
P
Y
D
Site 14
Y168
E
T
V
R
A
A
P
Y
D
W
R
L
E
P
G
Site 15
Y180
E
P
G
Q
Q
E
E
Y
Y
R
K
L
A
G
L
Site 16
Y181
P
G
Q
Q
E
E
Y
Y
R
K
L
A
G
L
V
Site 17
S205
P
V
F
L
I
G
H
S
L
G
C
L
H
L
L
Site 18
Y213
L
G
C
L
H
L
L
Y
F
L
L
R
Q
P
Q
Site 19
T270
L
K
E
E
Q
R
I
T
T
T
S
P
W
M
F
Site 20
T271
K
E
E
Q
R
I
T
T
T
S
P
W
M
F
P
Site 21
S273
E
Q
R
I
T
T
T
S
P
W
M
F
P
S
R
Site 22
S291
P
E
D
H
V
F
I
S
T
P
S
F
N
Y
T
Site 23
T292
E
D
H
V
F
I
S
T
P
S
F
N
Y
T
G
Site 24
S294
H
V
F
I
S
T
P
S
F
N
Y
T
G
R
D
Site 25
T298
S
T
P
S
F
N
Y
T
G
R
D
F
Q
R
F
Site 26
Y316
L
H
F
E
E
G
W
Y
M
W
L
Q
S
R
D
Site 27
T345
L
Y
G
V
G
L
P
T
P
R
T
Y
I
Y
D
Site 28
T348
V
G
L
P
T
P
R
T
Y
I
Y
D
H
G
F
Site 29
Y349
G
L
P
T
P
R
T
Y
I
Y
D
H
G
F
P
Site 30
Y351
P
T
P
R
T
Y
I
Y
D
H
G
F
P
Y
T
Site 31
T358
Y
D
H
G
F
P
Y
T
D
P
V
G
V
L
Y
Site 32
Y365
T
D
P
V
G
V
L
Y
E
D
G
D
D
T
V
Site 33
T371
L
Y
E
D
G
D
D
T
V
A
T
R
S
T
E
Site 34
T374
D
G
D
D
T
V
A
T
R
S
T
E
L
C
G
Site 35
T377
D
T
V
A
T
R
S
T
E
L
C
G
L
W
Q
Site 36
S429
Y
R
Q
G
P
P
A
S
P
T
A
S
P
E
P
Site 37
T431
Q
G
P
P
A
S
P
T
A
S
P
E
P
P
P
Site 38
S433
P
P
A
S
P
T
A
S
P
E
P
P
P
P
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation