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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Ig mu heavy chain disease protein
Full Name:
Ig mu heavy chain disease protein
Alias:
BOT
Type:
Mass (Da):
43057
Number AA:
391
UniProt ID:
P04220
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
K
E
E
E
A
R
L
S
G
R
D
M
Q
V
T
Site 2
T39
S
G
R
D
M
Q
V
T
S
Q
P
V
I
A
E
Site 3
S40
G
R
D
M
Q
V
T
S
Q
P
V
I
A
E
L
Site 4
S52
A
E
L
P
P
K
V
S
V
F
V
P
P
R
D
Site 5
S78
I
C
Q
A
T
G
F
S
P
R
Q
I
E
V
S
Site 6
S85
S
P
R
Q
I
E
V
S
W
L
R
E
G
K
Q
Site 7
T99
Q
V
G
S
G
V
T
T
D
E
V
E
A
E
A
Site 8
S109
V
E
A
E
A
K
E
S
G
P
T
T
Y
K
V
Site 9
T112
E
A
K
E
S
G
P
T
T
Y
K
V
T
S
T
Site 10
T113
A
K
E
S
G
P
T
T
Y
K
V
T
S
T
L
Site 11
Y114
K
E
S
G
P
T
T
Y
K
V
T
S
T
L
T
Site 12
T119
T
T
Y
K
V
T
S
T
L
T
I
K
E
S
D
Site 13
T121
Y
K
V
T
S
T
L
T
I
K
E
S
D
W
L
Site 14
S125
S
T
L
T
I
K
E
S
D
W
L
G
Q
S
M
Site 15
T143
R
V
D
H
R
G
L
T
F
Q
Q
N
A
S
S
Site 16
S150
T
F
Q
Q
N
A
S
S
M
C
G
P
D
Q
D
Site 17
S192
T
D
L
T
T
Y
D
S
V
T
I
S
W
T
R
Site 18
T194
L
T
T
Y
D
S
V
T
I
S
W
T
R
Q
D
Site 19
S196
T
Y
D
S
V
T
I
S
W
T
R
Q
D
G
E
Site 20
T207
Q
D
G
E
A
V
K
T
H
T
N
I
S
E
S
Site 21
T209
G
E
A
V
K
T
H
T
N
I
S
E
S
H
P
Site 22
S214
T
H
T
N
I
S
E
S
H
P
N
A
T
F
S
Site 23
T219
S
E
S
H
P
N
A
T
F
S
A
V
G
E
A
Site 24
S221
S
H
P
N
A
T
F
S
A
V
G
E
A
S
I
Site 25
S227
F
S
A
V
G
E
A
S
I
C
E
D
D
W
D
Site 26
T242
S
G
E
R
F
T
C
T
V
T
H
T
D
L
P
Site 27
T244
E
R
F
T
C
T
V
T
H
T
D
L
P
S
P
Site 28
T246
F
T
C
T
V
T
H
T
D
L
P
S
P
L
K
Site 29
S250
V
T
H
T
D
L
P
S
P
L
K
Q
T
I
S
Site 30
S257
S
P
L
K
Q
T
I
S
R
P
K
G
V
A
L
Site 31
Y270
A
L
H
R
P
D
V
Y
L
L
P
P
A
R
E
Site 32
S311
M
Q
R
G
Q
P
L
S
P
E
K
Y
V
T
S
Site 33
Y315
Q
P
L
S
P
E
K
Y
V
T
S
A
P
M
P
Site 34
T317
L
S
P
E
K
Y
V
T
S
A
P
M
P
E
P
Site 35
Y330
E
P
Q
A
P
G
R
Y
F
A
H
S
I
L
T
Site 36
S334
P
G
R
Y
F
A
H
S
I
L
T
V
S
E
E
Site 37
T337
Y
F
A
H
S
I
L
T
V
S
E
E
E
W
N
Site 38
S339
A
H
S
I
L
T
V
S
E
E
E
W
N
T
G
Site 39
T345
V
S
E
E
E
W
N
T
G
E
T
Y
T
C
V
Site 40
Y349
E
W
N
T
G
E
T
Y
T
C
V
V
A
H
E
Site 41
T363
E
A
L
P
N
R
V
T
E
R
T
V
D
K
S
Site 42
T366
P
N
R
V
T
E
R
T
V
D
K
S
T
G
K
Site 43
S370
T
E
R
T
V
D
K
S
T
G
K
P
T
L
Y
Site 44
T371
E
R
T
V
D
K
S
T
G
K
P
T
L
Y
N
Site 45
T375
D
K
S
T
G
K
P
T
L
Y
N
V
S
L
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation