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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TUBB4
Full Name:
Tubulin beta-4 chain
Alias:
Beta-5; TBB4; TUBB5; Tubulin 5 beta; Tubulin beta-4; Tubulin, beta 4; Tubulin, beta-4
Type:
Cytoskeletal protein - Microtubule dynamics
Mass (Da):
49586
Number AA:
444
UniProt ID:
P04350
International Prot ID:
IPI00023598
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003924
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0007018
GO:0051258
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
Site 2
T33
D
E
H
G
I
D
P
T
G
T
Y
H
G
D
S
Site 3
T35
H
G
I
D
P
T
G
T
Y
H
G
D
S
D
L
Site 4
Y36
G
I
D
P
T
G
T
Y
H
G
D
S
D
L
Q
Site 5
S40
T
G
T
Y
H
G
D
S
D
L
Q
L
E
R
I
Site 6
Y50
Q
L
E
R
I
N
V
Y
Y
N
E
A
T
G
G
Site 7
Y51
L
E
R
I
N
V
Y
Y
N
E
A
T
G
G
N
Site 8
T55
N
V
Y
Y
N
E
A
T
G
G
N
Y
V
P
R
Site 9
Y59
N
E
A
T
G
G
N
Y
V
P
R
A
V
L
V
Site 10
T72
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
Site 11
S75
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Site 12
S78
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
Site 13
S95
D
N
F
V
F
G
Q
S
G
A
G
N
N
W
A
Site 14
T107
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
Site 15
S126
V
V
R
K
E
A
E
S
C
D
C
L
Q
G
F
Site 16
T136
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
Site 17
S138
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
Site 18
T143
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
Site 19
S145
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
Site 20
T149
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
Site 21
T166
F
P
D
R
I
M
N
T
F
S
V
V
P
S
P
Site 22
S168
D
R
I
M
N
T
F
S
V
V
P
S
P
K
V
Site 23
S172
N
T
F
S
V
V
P
S
P
K
V
S
D
T
V
Site 24
S176
V
V
P
S
P
K
V
S
D
T
V
V
E
P
Y
Site 25
T178
P
S
P
K
V
S
D
T
V
V
E
P
Y
N
A
Site 26
Y183
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Site 27
S188
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
Site 28
T196
V
H
Q
L
V
E
N
T
D
E
T
Y
C
I
D
Site 29
T199
L
V
E
N
T
D
E
T
Y
C
I
D
N
E
A
Site 30
Y200
V
E
N
T
D
E
T
Y
C
I
D
N
E
A
L
Site 31
Y208
C
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
Site 32
T218
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
Site 33
T219
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
Site 34
T221
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
Site 35
Y222
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
Site 36
S230
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
Site 37
S234
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
Site 38
T274
M
P
G
F
A
P
L
T
S
R
G
S
Q
Q
Y
Site 39
S275
P
G
F
A
P
L
T
S
R
G
S
Q
Q
Y
R
Site 40
S278
A
P
L
T
S
R
G
S
Q
Q
Y
R
A
L
T
Site 41
Y281
T
S
R
G
S
Q
Q
Y
R
A
L
T
V
P
E
Site 42
T285
S
Q
Q
Y
R
A
L
T
V
P
E
L
T
Q
Q
Site 43
T290
A
L
T
V
P
E
L
T
Q
Q
M
F
D
A
K
Site 44
Y310
C
D
P
R
H
G
R
Y
L
T
V
A
A
V
F
Site 45
T312
P
R
H
G
R
Y
L
T
V
A
A
V
F
R
G
Site 46
S322
A
V
F
R
G
R
M
S
M
K
E
V
D
E
Q
Site 47
S332
E
V
D
E
Q
M
L
S
V
Q
S
K
N
S
S
Site 48
S335
E
Q
M
L
S
V
Q
S
K
N
S
S
Y
F
V
Site 49
S338
L
S
V
Q
S
K
N
S
S
Y
F
V
E
W
I
Site 50
S339
S
V
Q
S
K
N
S
S
Y
F
V
E
W
I
P
Site 51
Y340
V
Q
S
K
N
S
S
Y
F
V
E
W
I
P
N
Site 52
S382
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
Site 53
Y398
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
Site 54
Y425
L
V
S
E
Y
Q
Q
Y
Q
D
A
T
A
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation