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Protein Info
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Short Name:
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TrkA
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Full Name:
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High affinity nerve growth factor receptor
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Alias:
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EC 2.7.10.1; NTRK1; P140-TrkA; Slow nerve growth factor receptor; TRK
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Type:
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Protein-tyrosine kinase (receptor), TK group, Trk family
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Mass (Da):
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87497
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Number AA:
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796
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UniProt ID:
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P04629
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International Prot ID:
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IPI00514519
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Sequence:
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Retrieve full protein sequence
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GO Terms
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External Links
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Internal Links
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Cellular Component:
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GO:0005768
GO:0005887
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Uniprot
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OncoNet
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Molecular Function:
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GO:0005524
GO:0005030
GO:0004714
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PhosphoSite+
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KinaseNET
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Biological Process:
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GO:0007265
GO:0007190
GO:0007169
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Phosida
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TranscriptoNet
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STRING
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Kinexus Products
Nerve growth factor (NGF) receptor-tyrosine kinase; High affinity nerve growth factor receptor Y680+Y681 phosphosite-specific antibody AB-PK837#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK837#TrkSubtide - TrkA (NTRK1) protein kinase substrate peptide - Powder PE-01BJQ95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BJQ95#Nerve growth factor (NGF) receptor-tyrosine kinase / High affinity nerve growth factor receptor (S677-G684, human) pY680+pY681 phosphopeptide - Powder PE-04AHV95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AHV95
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Info Box
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A variety of parameters were considered in the selection of putative P-sites.
Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score
is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr
or P-Tyr sites. The Maximum KInase Score provides the calculated score for
highest match of 500 human protein kinases for the amino acid sequence
surrounding the target P-site as determined with Kinase Substrate Predictor V2.
The Sum KInase Score provides the additive sum of the positive individual Kinase
Substrate Predictor V2 scores from 500 human protein kinases. The Conservation
Score is the average of the percent similarity of the human P-site with the
equivalent P-site in 20 other diverse species. Click the coloured buttons below
to retrieve this and other information in the Info Box, or click the orange
buttons for relevant links. |
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| Phosphosites | |
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| | | -7 | -6 | -5 | -4 | -3 | -2 | -1 | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | | Expt. conf. | Effect | Kinase | PPase | Kinexus Products | | Ref. | Evol. | Kinase Pred. | P-site Match |
| | Site 1 | S14 | R | G | Q | L | G | W | H | S | W | A | A | G | P | G | S | |  |  | | | | | |  | | |
| | Site 2 | S123 | R | L | S | R | L | N | L | S | F | N | A | L | E | S | L | |  | | | | | | | | | |
| | Site 3 | S475 | F | M | T | L | G | G | S | S | L | S | P | T | E | G | K | | | | | | | | | | | |
| | Site 4 | S477 | T | L | G | G | S | S | L | S | P | T | E | G | K | G | S | | | | | | | | | | | |
| | Site 5 | T479 | G | G | S | S | L | S | P | T | E | G | K | G | S | G | L | | | | | | | | | | | |
| | Site 6 | S484 | S | P | T | E | G | K | G | S | G | L | Q | G | H | I | I | | | | | | | | | | | |
| | Site 7 | Y496 | H | I | I | E | N | P | Q | Y | F | S | D | A | C | V | H | | | | | | | | | | | |
| | Site 8 | S552 | A | L | K | E | A | S | E | S | A | R | Q | D | F | Q | R | | | | | | | | | | | |
| | Site 9 | S672 | K | I | G | D | F | G | M | S | R | D | I | Y | S | T | D | | | | | | | | | | | |
| | Site 10 | Y676 | F | G | M | S | R | D | I | Y | S | T | D | Y | Y | R | V | | | | | | | | | | | |
| | Site 11 | S677 | G | M | S | R | D | I | Y | S | T | D | Y | Y | R | V | G | | | | | | | | | | | |
| | Site 12 | T678 | M | S | R | D | I | Y | S | T | D | Y | Y | R | V | G | G | | | | | | | | | | | |
| | Site 13 | Y680 | R | D | I | Y | S | T | D | Y | Y | R | V | G | G | R | T | | | | | |  Nerve growth factor (NGF) receptor-tyrosine kinase; High affinity nerve growth factor receptor Y680+Y681 phosphosite-specific antibody AB-PK837#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK837#Nerve growth factor (NGF) receptor-tyrosine kinase / High affinity nerve growth factor receptor (S677-G684, human) pY680+pY681 phosphopeptide - Powder PE-04AHV95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AHV95 | | | | | |
| | Site 14 | Y681 | D | I | Y | S | T | D | Y | Y | R | V | G | G | R | T | M | | | | | | Nerve growth factor (NGF) receptor-tyrosine kinase; High affinity nerve growth factor receptor Y680+Y681 phosphosite-specific antibody AB-PK837#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK837#Nerve growth factor (NGF) receptor-tyrosine kinase / High affinity nerve growth factor receptor (S677-G684, human) pY680+pY681 phosphopeptide - Powder PE-04AHV95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AHV95 | | | | | |
| | Site 15 | Y701 | M | P | P | E | S | I | L | Y | R | K | F | T | T | E | S | | | | | | | | | | | |
| | Site 16 | T705 | S | I | L | Y | R | K | F | T | T | E | S | D | V | W | S | | | | | | | | | | | |
| | Site 17 | S708 | Y | R | K | F | T | T | E | S | D | V | W | S | F | G | V | | | | | | | | | | | |
| | Site 18 | Y729 | T | Y | G | K | Q | P | W | Y | Q | L | S | N | T | E | A | | | | | | | | | | | |
| | Site 19 | T741 | T | E | A | I | D | C | I | T | Q | G | R | E | L | E | R | | | | | | | | | | | |
| | Site 20 | Y757 | R | A | C | P | P | E | V | Y | A | I | M | R | G | C | W | | | | | | | | | | | |
| | Site 21 | S773 | R | E | P | Q | Q | R | H | S | I | K | D | V | H | A | R | | | | | | | | | | | |
| | Site 22 | Y791 | L | A | Q | A | P | P | V | Y | L | D | V | L | G | _ | _ | | | | | | | | | | | |
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Legend
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Confirmed in mammals
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Confirmed in related proteins or other species
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Predicted by Kinexus P-Site Prediction algorithm
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No data/link available
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Link available
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Products available
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