PhosphoNET

           
Protein Info 
   
Short Name:  TYMS
Full Name:  Thymidylate synthase
Alias:  HsT422; Thymidylate synthase (Thymidylate synthetase, isoform CRA_a); Thymidylate synthetase; TMS; TS; TSase; TYSY
Type:  Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 2.1.1.45; DNA repair; Nucleotide Metabolism - pyrimidine; Methyltransferase
Mass (Da):  35716
Number AA:  313
UniProt ID:  P04818
International Prot ID:  IPI00221108
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005829     Uniprot OncoNet
Molecular Function:  GO:0004799     PhosphoSite+ KinaseNET
Biological Process:  GO:0006281  GO:0006260  GO:0006231 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S6__MPVAGSELPRRPL
Site 2Y33PPHGELQYLGQIQHI
Site 3T51GVRKDDRTGTGTLSV
Site 4T53RKDDRTGTGTLSVFG
Site 5T55DDRTGTGTLSVFGMQ
Site 6S57RTGTGTLSVFGMQAR
Site 7S66FGMQARYSLRDEFPL
Site 8T75RDEFPLLTTKRVFWK
Site 9T76DEFPLLTTKRVFWKG
Site 10S114KIWDANGSRDFLDSL
Site 11S120GSRDFLDSLGFSTRE
Site 12S124FLDSLGFSTREEGDL
Site 13Y135EGDLGPVYGFQWRHF
Site 14Y146WRHFGAEYRDMESDY
Site 15S151AEYRDMESDYSGQGV
Site 16Y153YRDMESDYSGQGVDQ
Site 17S154RDMESDYSGQGVDQL
Site 18T167QLQRVIDTIKTNPDD
Site 19Y213SELSCQLYQRSGDMG
Site 20S216SCQLYQRSGDMGLGV
Site 21T251KPGDFIHTLGDAHIY
Site 22Y301EDFQIEGYNPHPTIK
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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