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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYBB
Full Name:
Cytochrome b-245 heavy chain
Alias:
CGD91-phox;Cytochrome b(558) subunit beta;Heme-binding membrane glycoprotein gp91phox;NADPH oxidase 2;Neutrophil cytochrome b 91 kDa polypeptide;Superoxide-generating NADPH oxidase heavy chain subunit;gp91-1;gp91-phox;p22 phagocyte B-cytochrome
Type:
Mass (Da):
65336
Number AA:
570
UniProt ID:
P04839
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y41
D
I
P
P
K
F
F
Y
T
R
K
L
L
G
S
Site 2
T42
I
P
P
K
F
F
Y
T
R
K
L
L
G
S
A
Site 3
S87
R
G
S
S
A
C
C
S
T
R
V
R
R
Q
L
Site 4
T99
R
Q
L
D
R
N
L
T
F
H
K
M
V
A
W
Site 5
S134
V
N
A
R
V
N
N
S
D
P
Y
S
V
A
L
Site 6
Y137
R
V
N
N
S
D
P
Y
S
V
A
L
S
E
L
Site 7
S138
V
N
N
S
D
P
Y
S
V
A
L
S
E
L
G
Site 8
S142
D
P
Y
S
V
A
L
S
E
L
G
D
R
Q
N
Site 9
S151
L
G
D
R
Q
N
E
S
Y
L
N
F
A
R
K
Site 10
Y152
G
D
R
Q
N
E
S
Y
L
N
F
A
R
K
R
Site 11
Y168
K
N
P
E
G
G
L
Y
L
A
V
T
L
L
A
Site 12
T196
I
I
T
S
S
T
K
T
I
R
R
S
Y
F
E
Site 13
Y201
T
K
T
I
R
R
S
Y
F
E
V
F
W
Y
T
Site 14
T232
E
R
I
V
R
G
Q
T
A
E
S
L
A
V
H
Site 15
S235
V
R
G
Q
T
A
E
S
L
A
V
H
N
I
T
Site 16
S291
R
L
V
R
F
W
R
S
Q
Q
K
V
V
I
T
Site 17
T341
K
L
E
W
H
P
F
T
L
T
S
A
P
E
E
Site 18
T343
E
W
H
P
F
T
L
T
S
A
P
E
E
D
F
Site 19
S395
D
G
P
F
G
T
A
S
E
D
V
F
S
Y
E
Site 20
Y425
S
I
L
K
S
V
W
Y
K
Y
C
N
N
A
T
Site 21
Y427
L
K
S
V
W
Y
K
Y
C
N
N
A
T
N
L
Site 22
Y440
N
L
K
L
K
K
I
Y
F
Y
W
L
C
R
D
Site 23
S463
D
L
L
Q
L
L
E
S
Q
M
Q
E
R
N
N
Site 24
Y479
G
F
L
S
Y
N
I
Y
L
T
G
W
D
E
S
Site 25
T481
L
S
Y
N
I
Y
L
T
G
W
D
E
S
Q
A
Site 26
T509
I
T
G
L
K
Q
K
T
L
Y
G
R
P
N
W
Site 27
Y511
G
L
K
Q
K
T
L
Y
G
R
P
N
W
D
N
Site 28
S525
N
E
F
K
T
I
A
S
Q
H
P
N
T
R
I
Site 29
T545
G
P
E
A
L
A
E
T
L
S
K
Q
S
I
S
Site 30
S547
E
A
L
A
E
T
L
S
K
Q
S
I
S
N
S
Site 31
S550
A
E
T
L
S
K
Q
S
I
S
N
S
E
S
G
Site 32
S552
T
L
S
K
Q
S
I
S
N
S
E
S
G
P
R
Site 33
S554
S
K
Q
S
I
S
N
S
E
S
G
P
R
G
V
Site 34
S556
Q
S
I
S
N
S
E
S
G
P
R
G
V
H
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation