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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
G-alpha2(I)
Full Name:
Guanine nucleotide-binding protein G(i) subunit alpha-2
Alias:
adenylate cyclase-inhibiting G alpha protein; GIP; GNAI2; GNAI2B; GTP-binding regulatory protein Gi alpha-2 chain; guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 2; guanine nucleotide-binding protein G(i), alpha-2 subunit
Type:
G protein; G protein, heterotrimeric
Mass (Da):
40451
Number AA:
355
UniProt ID:
P04899
International Prot ID:
IPI00748145
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005886
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003924
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007584
GO:0001973
GO:0007214
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
G
C
T
V
S
A
E
D
K
A
A
A
Site 2
S44
L
L
L
G
A
G
E
S
G
K
S
T
I
V
K
Site 3
S47
G
A
G
E
S
G
K
S
T
I
V
K
Q
M
K
Site 4
T48
A
G
E
S
G
K
S
T
I
V
K
Q
M
K
I
Site 5
Y61
K
I
I
H
E
D
G
Y
S
E
E
E
C
R
Q
Site 6
Y69
S
E
E
E
C
R
Q
Y
R
A
V
V
Y
S
N
Site 7
S111
A
R
Q
L
F
A
L
S
C
T
A
E
E
Q
G
Site 8
S144
V
Q
A
C
F
G
R
S
R
E
Y
Q
L
N
D
Site 9
Y147
C
F
G
R
S
R
E
Y
Q
L
N
D
S
A
A
Site 10
S152
R
E
Y
Q
L
N
D
S
A
A
Y
Y
L
N
D
Site 11
Y155
Q
L
N
D
S
A
A
Y
Y
L
N
D
L
E
R
Site 12
Y156
L
N
D
S
A
A
Y
Y
L
N
D
L
E
R
I
Site 13
S166
D
L
E
R
I
A
Q
S
D
Y
I
P
T
Q
Q
Site 14
Y168
E
R
I
A
Q
S
D
Y
I
P
T
Q
Q
D
V
Site 15
T182
V
L
R
T
R
V
K
T
T
G
I
V
E
T
H
Site 16
S207
F
D
V
G
G
Q
R
S
E
R
K
K
W
I
H
Site 17
T280
D
L
F
E
E
K
I
T
H
S
P
L
T
I
C
Site 18
T285
K
I
T
H
S
P
L
T
I
C
F
P
E
Y
T
Site 19
Y291
L
T
I
C
F
P
E
Y
T
G
A
N
K
Y
D
Site 20
Y297
E
Y
T
G
A
N
K
Y
D
E
A
A
S
Y
I
Site 21
S302
N
K
Y
D
E
A
A
S
Y
I
Q
S
K
F
E
Site 22
Y303
K
Y
D
E
A
A
S
Y
I
Q
S
K
F
E
D
Site 23
S306
E
A
A
S
Y
I
Q
S
K
F
E
D
L
N
K
Site 24
T317
D
L
N
K
R
K
D
T
K
E
I
Y
T
H
F
Site 25
Y321
R
K
D
T
K
E
I
Y
T
H
F
T
C
A
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation