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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLC4A2
Full Name:
Anion exchange protein 2
Alias:
AE2; AE2 anion exchanger; Anion exchange protein 2; Anion exchanger 2 type a; Anion exchanger 2 type b1; Anion exchanger 2 type b2; B3A2; BND3L; EPB3L1; Erythrocyte membrane protein band 3-like 1; HKB3; MPB3L; NBND3; Non-erythroid band 3-like protein; Solute carrier family 4, anion exchanger, member 2; Solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
Type:
Transport protein, facilitator
Mass (Da):
137009
Number AA:
1241
UniProt ID:
P04920
International Prot ID:
IPI00383597
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005624
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0005452
GO:0005452
GO:0008509
PhosphoSite+
KinaseNET
Biological Process:
GO:0006820
GO:0006811
GO:0006820
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
R
P
A
K
G
A
D
S
F
C
T
P
E
P
E
Site 2
T17
K
G
A
D
S
F
C
T
P
E
P
E
S
L
G
Site 3
S22
F
C
T
P
E
P
E
S
L
G
P
G
T
P
G
Site 4
T27
P
E
S
L
G
P
G
T
P
G
F
P
E
Q
E
Site 5
T41
E
E
D
E
L
H
R
T
L
G
V
E
R
F
E
Site 6
S56
E
I
L
Q
E
A
G
S
R
G
G
E
E
P
G
Site 7
S65
G
G
E
E
P
G
R
S
Y
G
E
E
D
F
E
Site 8
Y66
G
E
E
P
G
R
S
Y
G
E
E
D
F
E
Y
Site 9
Y73
Y
G
E
E
D
F
E
Y
H
R
Q
S
S
H
H
Site 10
S86
H
H
I
H
H
P
L
S
T
H
L
P
P
D
A
Site 11
T98
P
D
A
R
R
R
K
T
P
Q
G
P
G
R
K
Site 12
S113
P
R
R
R
P
G
A
S
P
T
G
E
T
P
T
Site 13
T115
R
R
P
G
A
S
P
T
G
E
T
P
T
I
E
Site 14
T118
G
A
S
P
T
G
E
T
P
T
I
E
E
G
E
Site 15
T120
S
P
T
G
E
T
P
T
I
E
E
G
E
E
D
Site 16
S132
E
E
D
E
D
E
A
S
E
A
E
G
A
R
A
Site 17
T141
A
E
G
A
R
A
L
T
Q
P
S
P
V
S
T
Site 18
S144
A
R
A
L
T
Q
P
S
P
V
S
T
P
S
S
Site 19
S147
L
T
Q
P
S
P
V
S
T
P
S
S
V
Q
F
Site 20
T148
T
Q
P
S
P
V
S
T
P
S
S
V
Q
F
F
Site 21
S150
P
S
P
V
S
T
P
S
S
V
Q
F
F
L
Q
Site 22
S151
S
P
V
S
T
P
S
S
V
Q
F
F
L
Q
E
Site 23
S161
F
F
L
Q
E
D
D
S
A
D
R
K
A
E
R
Site 24
T169
A
D
R
K
A
E
R
T
S
P
S
S
P
A
P
Site 25
S170
D
R
K
A
E
R
T
S
P
S
S
P
A
P
L
Site 26
S172
K
A
E
R
T
S
P
S
S
P
A
P
L
P
H
Site 27
S173
A
E
R
T
S
P
S
S
P
A
P
L
P
H
Q
Site 28
T183
P
L
P
H
Q
E
A
T
P
R
A
S
K
G
A
Site 29
S187
Q
E
A
T
P
R
A
S
K
G
A
Q
A
G
T
Site 30
S219
G
G
D
D
G
G
A
S
G
R
P
L
P
K
A
Site 31
S232
K
A
Q
P
G
H
R
S
Y
N
L
Q
E
R
R
Site 32
Y233
A
Q
P
G
H
R
S
Y
N
L
Q
E
R
R
R
Site 33
S243
Q
E
R
R
R
I
G
S
M
T
G
A
E
Q
A
Site 34
T245
R
R
R
I
G
S
M
T
G
A
E
Q
A
L
L
Site 35
T257
A
L
L
P
R
V
P
T
D
E
I
E
A
Q
T
Site 36
T264
T
D
E
I
E
A
Q
T
L
A
T
A
D
L
D
Site 37
S275
A
D
L
D
L
M
K
S
H
R
F
E
D
V
P
Site 38
S299
N
A
K
G
S
T
Q
S
G
R
E
G
R
E
P
Site 39
T309
E
G
R
E
P
G
P
T
P
R
A
R
P
R
A
Site 40
T393
L
L
D
L
D
Q
Q
T
L
P
G
V
A
H
Q
Site 41
S408
V
V
E
Q
M
V
I
S
D
Q
I
K
A
E
D
Site 42
S428
R
A
L
L
L
K
H
S
H
P
S
D
E
K
D
Site 43
S431
L
L
K
H
S
H
P
S
D
E
K
D
F
S
F
Site 44
S437
P
S
D
E
K
D
F
S
F
P
R
N
I
S
A
Site 45
S443
F
S
F
P
R
N
I
S
A
G
S
L
G
S
L
Site 46
S446
P
R
N
I
S
A
G
S
L
G
S
L
L
G
H
Site 47
S449
I
S
A
G
S
L
G
S
L
L
G
H
H
H
G
Site 48
S461
H
H
G
Q
G
A
E
S
D
P
H
V
T
E
P
Site 49
T466
A
E
S
D
P
H
V
T
E
P
L
M
G
G
V
Site 50
T496
P
A
P
P
A
G
I
T
R
S
K
S
K
H
E
Site 51
S498
P
P
A
G
I
T
R
S
K
S
K
H
E
L
K
Site 52
S500
A
G
I
T
R
S
K
S
K
H
E
L
K
L
L
Site 53
S564
F
L
L
L
G
P
S
S
A
N
M
D
Y
H
E
Site 54
Y569
P
S
S
A
N
M
D
Y
H
E
I
G
R
S
I
Site 55
S575
D
Y
H
E
I
G
R
S
I
S
T
L
M
S
D
Site 56
S577
H
E
I
G
R
S
I
S
T
L
M
S
D
K
Q
Site 57
S581
R
S
I
S
T
L
M
S
D
K
Q
F
H
E
A
Site 58
Y590
K
Q
F
H
E
A
A
Y
L
A
D
E
R
E
D
Site 59
T600
D
E
R
E
D
L
L
T
A
I
N
A
F
L
D
Site 60
S625
Q
G
E
E
L
L
R
S
V
A
H
F
Q
R
Q
Site 61
S654
G
A
G
L
E
P
K
S
A
Q
D
K
A
L
L
Site 62
T678
E
D
D
P
L
R
R
T
G
R
P
F
G
G
L
Site 63
Y693
I
R
D
V
R
R
R
Y
P
H
Y
L
S
D
F
Site 64
Y696
V
R
R
R
Y
P
H
Y
L
S
D
F
R
D
A
Site 65
S698
R
R
Y
P
H
Y
L
S
D
F
R
D
A
L
D
Site 66
S924
F
L
R
K
F
K
N
S
R
F
F
P
G
R
I
Site 67
T957
V
D
Y
S
I
E
D
T
Y
T
Q
K
L
S
V
Site 68
Y958
D
Y
S
I
E
D
T
Y
T
Q
K
L
S
V
P
Site 69
T959
Y
S
I
E
D
T
Y
T
Q
K
L
S
V
P
S
Site 70
S963
D
T
Y
T
Q
K
L
S
V
P
S
G
F
S
V
Site 71
S969
L
S
V
P
S
G
F
S
V
T
A
P
E
K
R
Site 72
T1153
P
K
H
H
P
D
V
T
Y
V
K
K
V
R
T
Site 73
Y1154
K
H
H
P
D
V
T
Y
V
K
K
V
R
T
L
Site 74
T1160
T
Y
V
K
K
V
R
T
L
R
M
H
L
F
T
Site 75
Y1234
E
R
E
G
V
D
E
Y
N
E
M
P
M
P
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation