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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATP1A1
Full Name:
Sodium/potassium-transporting ATPase subunit alpha-1
Alias:
A1A1; AT1A1; ATPase, Na+/K+ transporting, alpha 1 polypeptide; Hypothetical protein MGC38419; Na(+)/K(+) ATPase alpha-1 subunit; Na,K-ATPase 1; Na+/K+ ATPase 1; Sodium pump 1; Sodium pump subunit alpha-1; Sodium/potassium-transporting ATPase alpha-1 chain precursor
Type:
Hydrolase; EC 3.6.3.9
Mass (Da):
112896
Number AA:
1023
UniProt ID:
P05023
International Prot ID:
IPI00006482
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0042470
GO:0005890
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0015077
PhosphoSite+
KinaseNET
Biological Process:
GO:0006754
GO:0006813
GO:0006814
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
K
G
V
G
R
D
K
Y
E
P
A
A
V
S
E
Site 2
S16
K
Y
E
P
A
A
V
S
E
Q
G
D
K
K
G
Site 3
S40
D
E
L
K
K
E
V
S
M
D
D
H
K
L
S
Site 4
S47
S
M
D
D
H
K
L
S
L
D
E
L
H
R
K
Site 5
Y55
L
D
E
L
H
R
K
Y
G
T
D
L
S
R
G
Site 6
S60
R
K
Y
G
T
D
L
S
R
G
L
T
S
A
R
Site 7
T64
T
D
L
S
R
G
L
T
S
A
R
A
A
E
I
Site 8
T81
R
D
G
P
N
A
L
T
P
P
P
T
T
P
E
Site 9
T85
N
A
L
T
P
P
P
T
T
P
E
W
I
K
F
Site 10
T86
A
L
T
P
P
P
T
T
P
E
W
I
K
F
C
Site 11
Y131
E
P
Q
N
D
N
L
Y
L
G
V
V
L
S
A
Site 12
Y149
I
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
K
Site 13
S154
S
Y
Y
Q
E
A
K
S
S
K
I
M
E
S
F
Site 14
S155
Y
Y
Q
E
A
K
S
S
K
I
M
E
S
F
K
Site 15
S160
K
S
S
K
I
M
E
S
F
K
N
M
V
P
Q
Site 16
S216
N
G
C
K
V
D
N
S
S
L
T
G
E
S
E
Site 17
S217
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Site 18
T219
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
Site 19
S222
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
Site 20
T226
T
G
E
S
E
P
Q
T
R
S
P
D
F
T
N
Site 21
S228
E
S
E
P
Q
T
R
S
P
D
F
T
N
E
N
Site 22
T232
Q
T
R
S
P
D
F
T
N
E
N
P
L
E
T
Site 23
S246
T
R
N
I
A
F
F
S
T
N
C
V
E
G
T
Site 24
Y260
T
A
R
G
I
V
V
Y
T
G
D
R
T
V
M
Site 25
T261
A
R
G
I
V
V
Y
T
G
D
R
T
V
M
G
Site 26
S275
G
R
I
A
T
L
A
S
G
L
E
G
G
Q
T
Site 27
T282
S
G
L
E
G
G
Q
T
P
I
A
A
E
I
E
Site 28
T347
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
Site 29
T366
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
Site 30
S369
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
Site 31
T370
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
Site 32
S371
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
Site 33
T372
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
Site 34
S375
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Site 35
T378
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
Site 36
T382
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
Site 37
T402
N
Q
I
H
E
A
D
T
T
E
N
Q
S
G
V
Site 38
T403
Q
I
H
E
A
D
T
T
E
N
Q
S
G
V
S
Site 39
S410
T
E
N
Q
S
G
V
S
F
D
K
T
S
A
T
Site 40
T417
S
F
D
K
T
S
A
T
W
L
A
L
S
R
I
Site 41
S452
R
A
V
A
G
D
A
S
E
S
A
L
L
K
C
Site 42
Y474
V
K
E
M
R
E
R
Y
A
K
I
V
E
I
P
Site 43
S484
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
Site 44
Y488
P
F
N
S
T
N
K
Y
Q
L
S
I
H
K
N
Site 45
S491
S
T
N
K
Y
Q
L
S
I
H
K
N
P
N
T
Site 46
T498
S
I
H
K
N
P
N
T
S
E
P
Q
H
L
L
Site 47
S519
E
R
I
L
D
R
C
S
S
I
L
L
H
G
K
Site 48
S520
R
I
L
D
R
C
S
S
I
L
L
H
G
K
E
Site 49
Y542
K
D
A
F
Q
N
A
Y
L
E
L
G
G
L
G
Site 50
T573
P
E
G
F
Q
F
D
T
D
D
V
N
F
P
I
Site 51
S635
A
K
G
V
G
I
I
S
E
G
N
E
T
V
E
Site 52
T640
I
I
S
E
G
N
E
T
V
E
D
I
A
A
R
Site 53
S653
A
R
L
N
I
P
V
S
Q
V
N
P
R
D
A
Site 54
S668
K
A
C
V
V
H
G
S
D
L
K
D
M
T
S
Site 55
S675
S
D
L
K
D
M
T
S
E
Q
L
D
D
I
L
Site 56
Y684
Q
L
D
D
I
L
K
Y
H
T
E
I
V
F
A
Site 57
T686
D
D
I
L
K
Y
H
T
E
I
V
F
A
R
T
Site 58
S722
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
Site 59
S742
G
I
A
G
S
D
V
S
K
Q
A
A
D
M
I
Site 60
S775
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
Site 61
T779
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
Site 62
S829
L
A
Y
E
Q
A
E
S
D
I
M
K
R
Q
P
Site 63
T841
R
Q
P
R
N
P
K
T
D
K
L
V
N
E
R
Site 64
Y902
I
N
D
V
E
D
S
Y
G
Q
Q
W
T
Y
E
Site 65
Y908
S
Y
G
Q
Q
W
T
Y
E
Q
R
K
I
V
E
Site 66
T939
A
D
L
V
I
C
K
T
R
R
N
S
V
F
Q
Site 67
S943
I
C
K
T
R
R
N
S
V
F
Q
Q
G
M
K
Site 68
S969
T
A
L
A
A
F
L
S
Y
C
P
G
M
G
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation