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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYP17A1
Full Name:
Steroid 17-alpha-hydroxylase/17,20 lyase
Alias:
CP17A; CPT7; CYP17; CYPXVII; Cytochrome P450 17A1; Cytochrome P450, family 17, subfamily A, polypeptide 1; P450c17; P450-C17; S17AH; Steroid 17-alpha-monooxygenase
Type:
Lipid Metabolism - C21-steroid hormone; Oxidoreductase; EC 1.14.99.9
Mass (Da):
57371
Number AA:
508
UniProt ID:
P05093
International Prot ID:
IPI00006665
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005789
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0009055
GO:0020037
GO:0019825
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
GO:0007548
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y27
R
R
C
P
G
A
K
Y
P
K
S
L
L
S
L
Site 2
Y60
F
F
K
L
Q
K
K
Y
G
P
I
Y
S
V
R
Site 3
Y64
Q
K
K
Y
G
P
I
Y
S
V
R
M
G
T
K
Site 4
S65
K
K
Y
G
P
I
Y
S
V
R
M
G
T
K
T
Site 5
T70
I
Y
S
V
R
M
G
T
K
T
T
V
I
V
G
Site 6
T72
S
V
R
M
G
T
K
T
T
V
I
V
G
H
H
Site 7
T73
V
R
M
G
T
K
T
T
V
I
V
G
H
H
Q
Site 8
S94
I
K
K
G
K
D
F
S
G
R
P
Q
M
A
T
Site 9
T101
S
G
R
P
Q
M
A
T
L
D
I
A
S
N
N
Site 10
S106
M
A
T
L
D
I
A
S
N
N
R
K
G
I
A
Site 11
T131
H
R
R
L
A
M
A
T
F
A
L
F
K
D
G
Site 12
Y188
L
I
C
F
N
T
S
Y
K
N
G
D
P
E
L
Site 13
S210
E
G
I
I
D
N
L
S
K
D
S
L
V
D
L
Site 14
T228
L
K
I
F
P
N
K
T
L
E
K
L
K
S
H
Site 15
S234
K
T
L
E
K
L
K
S
H
V
K
I
R
N
D
Site 16
Y250
L
N
K
I
L
E
N
Y
K
E
K
F
R
S
D
Site 17
S256
N
Y
K
E
K
F
R
S
D
S
I
T
N
M
L
Site 18
S258
K
E
K
F
R
S
D
S
I
T
N
M
L
D
T
Site 19
T260
K
F
R
S
D
S
I
T
N
M
L
D
T
L
M
Site 20
T265
S
I
T
N
M
L
D
T
L
M
Q
A
K
M
N
Site 21
S284
N
A
G
P
D
Q
D
S
E
L
L
S
D
N
H
Site 22
S288
D
Q
D
S
E
L
L
S
D
N
H
I
L
T
T
Site 23
Y329
P
Q
V
K
K
K
L
Y
E
E
I
D
Q
N
V
Site 24
S339
I
D
Q
N
V
G
F
S
R
T
P
T
I
S
D
Site 25
T341
Q
N
V
G
F
S
R
T
P
T
I
S
D
R
N
Site 26
T343
V
G
F
S
R
T
P
T
I
S
D
R
N
R
L
Site 27
S345
F
S
R
T
P
T
I
S
D
R
N
R
L
L
L
Site 28
S380
H
K
A
N
V
D
S
S
I
G
E
F
A
V
D
Site 29
S475
P
D
D
G
Q
L
P
S
L
E
G
I
P
K
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation