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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SERPINE1
Full Name:
Plasminogen activator inhibitor 1
Alias:
Endothelial plasminogen activator inhibitor; PAI; PAI1; PAI-1; PLANH1; Plasminogen activator inhibitor, type I; Serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), 1; Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), 1
Type:
Uncharacterized protein
Mass (Da):
45060
Number AA:
402
UniProt ID:
P05121
International Prot ID:
IPI00007118
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0002020
GO:0004252
GO:0004867
PhosphoSite+
KinaseNET
Biological Process:
GO:0007596
GO:0001300
GO:0042730
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
S
A
V
H
H
P
P
S
Y
V
A
H
L
A
S
Site 2
Y30
A
V
H
H
P
P
S
Y
V
A
H
L
A
S
D
Site 3
S58
K
D
R
N
V
V
F
S
P
Y
G
V
A
S
V
Site 4
T77
Q
L
T
T
G
G
E
T
Q
Q
Q
I
Q
A
A
Site 5
Y102
A
P
A
L
R
H
L
Y
K
E
L
M
G
P
W
Site 6
T117
N
K
D
E
I
S
T
T
D
A
I
F
V
Q
R
Site 7
T143
F
F
R
L
F
R
S
T
V
K
Q
V
D
F
S
Site 8
Y193
L
V
L
V
N
A
L
Y
F
N
G
Q
W
K
T
Site 9
T200
Y
F
N
G
Q
W
K
T
P
F
P
D
S
S
T
Site 10
S205
W
K
T
P
F
P
D
S
S
T
H
R
R
L
F
Site 11
S206
K
T
P
F
P
D
S
S
T
H
R
R
L
F
H
Site 12
T207
T
P
F
P
D
S
S
T
H
R
R
L
F
H
K
Site 13
S215
H
R
R
L
F
H
K
S
D
G
S
T
V
S
V
Site 14
T219
F
H
K
S
D
G
S
T
V
S
V
P
M
M
A
Site 15
S221
K
S
D
G
S
T
V
S
V
P
M
M
A
Q
T
Site 16
Y243
F
T
T
P
D
G
H
Y
Y
D
I
L
E
L
P
Site 17
Y244
T
T
P
D
G
H
Y
Y
D
I
L
E
L
P
Y
Site 18
T290
S
H
W
K
G
N
M
T
R
L
P
R
L
L
V
Site 19
S331
Q
F
Q
A
D
F
T
S
L
S
D
Q
E
P
L
Site 20
S333
Q
A
D
F
T
S
L
S
D
Q
E
P
L
H
V
Site 21
S354
V
K
I
E
V
N
E
S
G
T
V
A
S
S
S
Site 22
T356
I
E
V
N
E
S
G
T
V
A
S
S
S
T
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation