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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PKCg
Full Name:
Protein kinase C gamma type
Alias:
EC 2.7.11.13; Kinase PKC-gamma; KPCG; MGC57564; PKC I; PKCC; PKC-gamma; PKC-I; PRKCG; Protein kinase C, gamma; Protein kinase C, gamma type; SCA14
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.13; AGC group; PKC family; Alpha subfamily
Mass (Da):
78448
Number AA:
697
UniProt ID:
P05129
International Prot ID:
IPI00007128
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005509
GO:0004697
PhosphoSite+
KinaseNET
Biological Process:
GO:0008219
GO:0007242
GO:0042177
Phosida
TranscriptoNet
STRING
Kinexus Products
PKCtide KinSub - PKCtide peptide substrate - Powder PE-01ADL95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ADL95#Syntide-2 KinSub - Syntide-2 protein kinase substrate peptide - Powder PE-01AQB95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AQB95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
L
G
P
G
V
G
D
S
E
G
G
P
R
P
L
Site 2
S35
K
V
V
H
E
V
K
S
H
K
F
T
A
R
F
Site 3
T39
E
V
K
S
H
K
F
T
A
R
F
F
K
Q
P
Site 4
T47
A
R
F
F
K
Q
P
T
F
C
S
H
C
T
D
Site 5
T82
R
R
C
H
E
F
V
T
F
E
C
P
G
A
G
Site 6
T94
G
A
G
K
G
P
Q
T
D
D
P
R
N
K
H
Site 7
S107
K
H
K
F
R
L
H
S
Y
S
S
P
T
F
C
Site 8
Y108
H
K
F
R
L
H
S
Y
S
S
P
T
F
C
D
Site 9
S109
K
F
R
L
H
S
Y
S
S
P
T
F
C
D
H
Site 10
Y122
D
H
C
G
S
L
L
Y
G
L
V
H
Q
G
M
Site 11
S148
R
C
V
R
S
V
P
S
L
C
G
V
D
H
T
Site 12
T155
S
L
C
G
V
D
H
T
E
R
R
G
R
L
Q
Site 13
T169
Q
L
E
I
R
A
P
T
A
D
E
I
H
V
T
Site 14
T176
T
A
D
E
I
H
V
T
V
G
E
A
R
N
L
Site 15
S192
P
M
D
P
N
G
L
S
D
P
Y
V
K
L
K
Site 16
Y195
P
N
G
L
S
D
P
Y
V
K
L
K
L
I
P
Site 17
T208
I
P
D
P
R
N
L
T
K
Q
K
T
R
T
V
Site 18
T212
R
N
L
T
K
Q
K
T
R
T
V
K
A
T
L
Site 19
T214
L
T
K
Q
K
T
R
T
V
K
A
T
L
N
P
Site 20
T218
K
T
R
T
V
K
A
T
L
N
P
V
W
N
E
Site 21
T226
L
N
P
V
W
N
E
T
F
V
F
N
L
K
P
Site 22
S241
G
D
V
E
R
R
L
S
V
E
V
W
D
W
D
Site 23
Y275
K
A
P
V
D
G
W
Y
K
L
L
N
Q
E
E
Site 24
Y285
L
N
Q
E
E
G
E
Y
Y
N
V
P
V
A
D
Site 25
Y286
N
Q
E
E
G
E
Y
Y
N
V
P
V
A
D
A
Site 26
S297
V
A
D
A
D
N
C
S
L
L
Q
K
F
E
A
Site 27
Y307
Q
K
F
E
A
C
N
Y
P
L
E
L
Y
E
R
Site 28
Y312
C
N
Y
P
L
E
L
Y
E
R
V
R
M
G
P
Site 29
S320
E
R
V
R
M
G
P
S
S
S
P
I
P
S
P
Site 30
S321
R
V
R
M
G
P
S
S
S
P
I
P
S
P
S
Site 31
S322
V
R
M
G
P
S
S
S
P
I
P
S
P
S
P
Site 32
S326
P
S
S
S
P
I
P
S
P
S
P
S
P
T
D
Site 33
S328
S
S
P
I
P
S
P
S
P
S
P
T
D
P
K
Site 34
S330
P
I
P
S
P
S
P
S
P
T
D
P
K
R
C
Site 35
T332
P
S
P
S
P
S
P
T
D
P
K
R
C
F
F
Site 36
S342
K
R
C
F
F
G
A
S
P
G
R
L
H
I
S
Site 37
S373
M
L
A
E
R
R
G
S
D
E
L
Y
A
I
K
Site 38
Y377
R
R
G
S
D
E
L
Y
A
I
K
I
L
K
K
Site 39
T396
Q
D
D
D
V
D
C
T
L
V
E
K
R
V
L
Site 40
T418
G
G
R
P
H
F
L
T
Q
L
H
S
T
F
Q
Site 41
S422
H
F
L
T
Q
L
H
S
T
F
Q
T
P
D
R
Site 42
T426
Q
L
H
S
T
F
Q
T
P
D
R
L
Y
F
V
Site 43
Y431
F
Q
T
P
D
R
L
Y
F
V
M
E
Y
V
T
Site 44
Y444
V
T
G
G
D
L
M
Y
H
I
Q
Q
L
G
K
Site 45
T510
K
E
N
V
F
P
G
T
T
T
R
T
F
C
G
Site 46
T511
E
N
V
F
P
G
T
T
T
R
T
F
C
G
T
Site 47
T512
N
V
F
P
G
T
T
T
R
T
F
C
G
T
P
Site 48
T514
F
P
G
T
T
T
R
T
F
C
G
T
P
D
Y
Site 49
T518
T
T
R
T
F
C
G
T
P
D
Y
I
A
P
E
Site 50
Y521
T
F
C
G
T
P
D
Y
I
A
P
E
I
I
A
Site 51
Y529
I
A
P
E
I
I
A
Y
Q
P
Y
G
K
S
V
Site 52
Y532
E
I
I
A
Y
Q
P
Y
G
K
S
V
D
W
W
Site 53
T573
A
I
M
E
Q
T
V
T
Y
P
K
S
L
S
R
Site 54
Y574
I
M
E
Q
T
V
T
Y
P
K
S
L
S
R
E
Site 55
S577
Q
T
V
T
Y
P
K
S
L
S
R
E
A
V
A
Site 56
T591
A
I
C
K
G
F
L
T
K
H
P
G
K
R
L
Site 57
S600
H
P
G
K
R
L
G
S
G
P
D
G
E
P
T
Site 58
T607
S
G
P
D
G
E
P
T
I
R
A
H
G
F
F
Site 59
S639
R
P
R
P
C
G
R
S
G
E
N
F
D
K
F
Site 60
T648
E
N
F
D
K
F
F
T
R
A
A
P
A
L
T
Site 61
T655
T
R
A
A
P
A
L
T
P
P
D
R
L
V
L
Site 62
S664
P
D
R
L
V
L
A
S
I
D
Q
A
D
F
Q
Site 63
T674
Q
A
D
F
Q
G
F
T
Y
V
N
P
D
F
V
Site 64
Y675
A
D
F
Q
G
F
T
Y
V
N
P
D
F
V
H
Site 65
S687
F
V
H
P
D
A
R
S
P
T
S
P
V
P
V
Site 66
T689
H
P
D
A
R
S
P
T
S
P
V
P
V
P
V
Site 67
S690
P
D
A
R
S
P
T
S
P
V
P
V
P
V
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation