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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PCCA
Full Name:
Propionyl-CoA carboxylase alpha chain, mitochondrial
Alias:
PCCase subunit alpha; Propanoyl-CoA:carbon dioxide ligase subunit alpha; Propionyl Coenzyme A carboxylase, alpha polypeptide; Propionyl-CoA carboxylase alpha chain, mitochondrial
Type:
EC 6.4.1.3; Ligase; Carbohydrate Metabolism - propanoate; Amino Acid Metabolism - valine, leucine and isoleucine degradation
Mass (Da):
77354
Number AA:
703
UniProt ID:
P05165
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0009374
GO:0019899
PhosphoSite+
KinaseNET
Biological Process:
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
L
S
A
A
L
R
T
L
K
H
V
L
Y
Y
Site 2
Y14
R
T
L
K
H
V
L
Y
Y
S
R
Q
C
L
M
Site 3
S23
S
R
Q
C
L
M
V
S
R
N
L
G
S
V
G
Site 4
Y31
R
N
L
G
S
V
G
Y
D
P
N
E
K
T
F
Site 5
T37
G
Y
D
P
N
E
K
T
F
D
K
I
L
V
A
Site 6
S75
H
S
D
V
D
A
S
S
V
H
V
K
M
A
D
Site 7
S93
C
V
G
P
A
P
T
S
K
S
Y
L
N
M
D
Site 8
S95
G
P
A
P
T
S
K
S
Y
L
N
M
D
A
I
Site 9
Y118
A
Q
A
V
H
P
G
Y
G
F
L
S
E
N
K
Site 10
S122
H
P
G
Y
G
F
L
S
E
N
K
E
F
A
R
Site 11
S196
Y
P
V
M
I
K
A
S
A
G
G
G
G
K
G
Site 12
S220
T
R
D
G
F
R
L
S
S
Q
E
A
A
S
S
Site 13
S221
R
D
G
F
R
L
S
S
Q
E
A
A
S
S
F
Site 14
S227
S
S
Q
E
A
A
S
S
F
G
D
D
R
L
L
Site 15
T287
S
I
F
L
D
A
E
T
R
R
A
M
G
E
Q
Site 16
Y321
V
D
S
K
K
N
F
Y
F
L
E
M
N
T
R
Site 17
Y355
M
I
R
V
A
K
G
Y
P
L
R
H
K
Q
A
Site 18
Y376
W
A
V
E
C
R
V
Y
A
E
D
P
Y
K
S
Site 19
Y381
R
V
Y
A
E
D
P
Y
K
S
F
G
L
P
S
Site 20
S383
Y
A
E
D
P
Y
K
S
F
G
L
P
S
I
G
Site 21
S388
Y
K
S
F
G
L
P
S
I
G
R
L
S
Q
Y
Site 22
S393
L
P
S
I
G
R
L
S
Q
Y
Q
E
P
L
H
Site 23
Y395
S
I
G
R
L
S
Q
Y
Q
E
P
L
H
L
P
Site 24
S408
L
P
G
V
R
V
D
S
G
I
Q
P
G
S
D
Site 25
S414
D
S
G
I
Q
P
G
S
D
I
S
I
Y
Y
D
Site 26
Y419
P
G
S
D
I
S
I
Y
Y
D
P
M
I
S
K
Site 27
Y420
G
S
D
I
S
I
Y
Y
D
P
M
I
S
K
L
Site 28
T429
P
M
I
S
K
L
I
T
Y
G
S
D
R
T
E
Site 29
S432
S
K
L
I
T
Y
G
S
D
R
T
E
A
L
K
Site 30
S467
L
R
E
V
I
I
N
S
R
F
V
K
G
D
I
Site 31
S475
R
F
V
K
G
D
I
S
T
K
F
L
S
D
V
Site 32
S480
D
I
S
T
K
F
L
S
D
V
Y
P
D
G
F
Site 33
Y483
T
K
F
L
S
D
V
Y
P
D
G
F
K
G
H
Site 34
T493
G
F
K
G
H
M
L
T
K
S
E
K
N
Q
L
Site 35
S495
K
G
H
M
L
T
K
S
E
K
N
Q
L
L
A
Site 36
T546
K
L
H
D
K
V
H
T
V
V
A
S
N
N
G
Site 37
S557
S
N
N
G
S
V
F
S
V
E
V
D
G
S
K
Site 38
S563
F
S
V
E
V
D
G
S
K
L
N
V
T
S
T
Site 39
S569
G
S
K
L
N
V
T
S
T
W
N
L
A
S
P
Site 40
T570
S
K
L
N
V
T
S
T
W
N
L
A
S
P
L
Site 41
S581
A
S
P
L
L
S
V
S
V
D
G
T
Q
R
T
Site 42
T588
S
V
D
G
T
Q
R
T
V
Q
C
L
S
R
E
Site 43
S593
Q
R
T
V
Q
C
L
S
R
E
A
G
G
N
M
Site 44
S601
R
E
A
G
G
N
M
S
I
Q
F
L
G
T
V
Site 45
T607
M
S
I
Q
F
L
G
T
V
Y
K
V
N
I
L
Site 46
Y609
I
Q
F
L
G
T
V
Y
K
V
N
I
L
T
R
Site 47
T630
K
F
M
L
E
K
V
T
E
D
T
S
S
V
L
Site 48
S634
E
K
V
T
E
D
T
S
S
V
L
R
S
P
M
Site 49
S635
K
V
T
E
D
T
S
S
V
L
R
S
P
M
P
Site 50
S673
E
A
M
K
M
Q
N
S
M
T
A
G
K
T
G
Site 51
T679
N
S
M
T
A
G
K
T
G
T
V
K
S
V
H
Site 52
T681
M
T
A
G
K
T
G
T
V
K
S
V
H
C
Q
Site 53
S684
G
K
T
G
T
V
K
S
V
H
C
Q
A
G
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation