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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYP2E1
Full Name:
Cytochrome P450 2E1
Alias:
CP2E1; CYP2E; CYPIIE1; cytochrome P450, family 2, subfamily E, polypeptide 1; P450-J
Type:
Lipid Metabolism - arachidonic acid; Mitochondrial; Oxidoreductase; Endoplasmic reticulum; Lipid Metabolism - linoleic acid; Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 1.14.14.1
Mass (Da):
56849
Number AA:
493
UniProt ID:
P05181
International Prot ID:
IPI00007282
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0005792
Uniprot
OncoNet
Molecular Function:
GO:0009055
GO:0020037
GO:0016709
PhosphoSite+
KinaseNET
Biological Process:
GO:0017144
GO:0016098
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S56
E
L
K
N
I
P
K
S
F
T
R
L
A
Q
R
Site 2
T58
K
N
I
P
K
S
F
T
R
L
A
Q
R
F
G
Site 3
T69
Q
R
F
G
P
V
F
T
L
Y
V
G
S
Q
R
Site 4
S74
V
F
T
L
Y
V
G
S
Q
R
M
V
V
M
H
Site 5
Y83
R
M
V
V
M
H
G
Y
K
A
V
K
E
A
L
Site 6
Y93
V
K
E
A
L
L
D
Y
K
D
E
F
S
G
R
Site 7
S98
L
D
Y
K
D
E
F
S
G
R
G
D
L
P
A
Site 8
T121
I
I
F
N
N
G
P
T
W
K
D
I
R
R
F
Site 9
S129
W
K
D
I
R
R
F
S
L
T
T
L
R
N
Y
Site 10
T131
D
I
R
R
F
S
L
T
T
L
R
N
Y
G
M
Site 11
T132
I
R
R
F
S
L
T
T
L
R
N
Y
G
M
G
Site 12
Y136
S
L
T
T
L
R
N
Y
G
M
G
K
Q
G
N
Site 13
S145
M
G
K
Q
G
N
E
S
R
I
Q
R
E
A
H
Site 14
T161
L
L
E
A
L
R
K
T
Q
G
Q
P
F
D
P
Site 15
Y191
L
F
R
K
H
F
D
Y
N
D
E
K
F
L
R
Site 16
Y201
E
K
F
L
R
L
M
Y
L
F
N
E
N
F
H
Site 17
T212
E
N
F
H
L
L
S
T
P
W
L
Q
L
Y
N
Site 18
Y218
S
T
P
W
L
Q
L
Y
N
N
F
P
S
F
L
Site 19
Y227
N
F
P
S
F
L
H
Y
L
P
G
S
H
R
K
Site 20
S231
F
L
H
Y
L
P
G
S
H
R
K
V
I
K
N
Site 21
Y245
N
V
A
E
V
K
E
Y
V
S
E
R
V
K
E
Site 22
S247
A
E
V
K
E
Y
V
S
E
R
V
K
E
H
H
Site 23
S256
R
V
K
E
H
H
Q
S
L
D
P
N
C
P
R
Site 24
T266
P
N
C
P
R
D
L
T
D
C
L
L
V
E
M
Site 25
Y284
K
H
S
A
E
R
L
Y
T
M
D
G
I
T
V
Site 26
T285
H
S
A
E
R
L
Y
T
M
D
G
I
T
V
T
Site 27
T306
A
G
T
E
T
T
S
T
T
L
R
Y
G
L
L
Site 28
S336
I
D
R
V
I
G
P
S
R
I
P
A
I
K
D
Site 29
Y349
K
D
R
Q
E
M
P
Y
M
D
A
V
V
H
E
Site 30
T362
H
E
I
Q
R
F
I
T
L
V
P
S
N
L
P
Site 31
S366
R
F
I
T
L
V
P
S
N
L
P
H
E
A
T
Site 32
T373
S
N
L
P
H
E
A
T
R
D
T
I
F
R
G
Site 33
T376
P
H
E
A
T
R
D
T
I
F
R
G
Y
L
I
Site 34
Y381
R
D
T
I
F
R
G
Y
L
I
P
K
G
T
V
Site 35
T387
G
Y
L
I
P
K
G
T
V
V
V
P
T
L
D
Site 36
Y398
P
T
L
D
S
V
L
Y
D
N
Q
E
F
P
D
Site 37
Y423
N
E
N
G
K
F
K
Y
S
D
Y
F
K
P
F
Site 38
S424
E
N
G
K
F
K
Y
S
D
Y
F
K
P
F
S
Site 39
Y426
G
K
F
K
Y
S
D
Y
F
K
P
F
S
T
G
Site 40
S431
S
D
Y
F
K
P
F
S
T
G
K
R
V
C
A
Site 41
T432
D
Y
F
K
P
F
S
T
G
K
R
V
C
A
G
Site 42
S472
D
P
K
D
I
D
L
S
P
I
H
I
G
F
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation