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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EIF2S1
Full Name:
Eukaryotic translation initiation factor 2 subunit 1
Alias:
EIF2; EIF2A; EIF-2A; EIF-2alpha; EIF-2-alpha; Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; Eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa; IF2A
Type:
Protein synthesis protein
Mass (Da):
36112
Number AA:
315
UniProt ID:
P05198
International Prot ID:
IPI00219678
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005850
GO:0005844
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0005515
GO:0003743
PhosphoSite+
KinaseNET
Biological Process:
GO:0006412
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
P
G
L
S
C
R
F
Y
Q
H
K
F
P
E
V
Site 2
S26
V
V
M
V
N
V
R
S
I
A
E
M
G
A
Y
Site 3
S49
I
E
G
M
I
L
L
S
E
L
S
R
R
R
I
Site 4
S52
M
I
L
L
S
E
L
S
R
R
R
I
R
S
I
Site 5
S58
L
S
R
R
R
I
R
S
I
N
K
L
I
R
I
Site 6
Y82
R
V
D
K
E
K
G
Y
I
D
L
S
K
R
R
Site 7
S86
E
K
G
Y
I
D
L
S
K
R
R
V
S
P
E
Site 8
S91
D
L
S
K
R
R
V
S
P
E
E
A
I
K
C
Site 9
T103
I
K
C
E
D
K
F
T
K
S
K
T
V
Y
S
Site 10
S105
C
E
D
K
F
T
K
S
K
T
V
Y
S
I
L
Site 11
T107
D
K
F
T
K
S
K
T
V
Y
S
I
L
R
H
Site 12
S110
T
K
S
K
T
V
Y
S
I
L
R
H
V
A
E
Site 13
Y121
H
V
A
E
V
L
E
Y
T
K
D
E
Q
L
E
Site 14
S129
T
K
D
E
Q
L
E
S
L
F
Q
R
T
A
W
Site 15
Y142
A
W
V
F
D
D
K
Y
K
R
P
G
Y
G
A
Site 16
Y147
D
K
Y
K
R
P
G
Y
G
A
Y
D
A
F
K
Site 17
Y150
K
R
P
G
Y
G
A
Y
D
A
F
K
H
A
V
Site 18
S158
D
A
F
K
H
A
V
S
D
P
S
I
L
D
S
Site 19
S161
K
H
A
V
S
D
P
S
I
L
D
S
L
D
L
Site 20
S165
S
D
P
S
I
L
D
S
L
D
L
N
E
D
E
Site 21
T185
N
N
I
N
R
R
L
T
P
Q
A
V
K
I
R
Site 22
Y200
A
D
I
E
V
A
C
Y
G
Y
E
G
I
D
A
Site 23
Y202
I
E
V
A
C
Y
G
Y
E
G
I
D
A
V
K
Site 24
S219
L
R
A
G
L
N
C
S
T
E
N
M
P
I
K
Site 25
Y235
N
L
I
A
P
P
R
Y
V
M
T
T
T
T
L
Site 26
T239
P
P
R
Y
V
M
T
T
T
T
L
E
R
T
E
Site 27
T240
P
R
Y
V
M
T
T
T
T
L
E
R
T
E
G
Site 28
T241
R
Y
V
M
T
T
T
T
L
E
R
T
E
G
L
Site 29
T279
Q
M
E
P
K
V
V
T
D
T
D
E
T
E
L
Site 30
T281
E
P
K
V
V
T
D
T
D
E
T
E
L
A
R
Site 31
T284
V
V
T
D
T
D
E
T
E
L
A
R
Q
M
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation