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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLR3D
Full Name:
DNA-directed RNA polymerase III subunit RPC4
Alias:
Bn51t; DNA-directed RNA polymerase III subunit D; Polr3d; Polymerase (rna) iii (dna directed) polypeptide d; Polymerase (rna) iii (dna directed) polypeptide d, 44kda; Rpc4; Rpc53; Tsbn51
Type:
Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine
Mass (Da):
44396
Number AA:
398
UniProt ID:
P05423
International Prot ID:
IPI00215978
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005666
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003899
PhosphoSite+
KinaseNET
Biological Process:
GO:0045089
GO:0032728
GO:0006383
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
E
G
N
A
A
G
E
Site 2
S11
G
N
A
A
G
E
P
S
T
P
G
G
P
R
P
Site 3
T12
N
A
A
G
E
P
S
T
P
G
G
P
R
P
L
Site 4
T21
G
G
P
R
P
L
L
T
G
A
R
G
L
I
G
Site 5
T36
R
R
P
A
P
P
L
T
P
G
R
L
P
S
I
Site 6
S42
L
T
P
G
R
L
P
S
I
R
S
R
D
L
T
Site 7
S45
G
R
L
P
S
I
R
S
R
D
L
T
L
G
G
Site 8
T49
S
I
R
S
R
D
L
T
L
G
G
V
K
K
K
Site 9
T57
L
G
G
V
K
K
K
T
F
T
P
N
I
I
S
Site 10
T59
G
V
K
K
K
T
F
T
P
N
I
I
S
R
K
Site 11
S105
G
R
P
E
V
I
Q
S
H
S
I
F
E
Q
G
Site 12
S107
P
E
V
I
Q
S
H
S
I
F
E
Q
G
P
A
Site 13
T126
K
K
G
N
W
D
K
T
V
D
V
S
D
M
G
Site 14
T147
I
K
K
E
K
R
E
T
D
E
E
T
K
Q
I
Site 15
T173
D
P
G
L
R
N
D
T
R
N
M
P
V
Q
L
Site 16
S185
V
Q
L
P
L
A
H
S
G
W
L
F
K
E
E
Site 17
T242
P
P
K
A
A
R
K
T
P
G
L
P
K
D
V
Site 18
S250
P
G
L
P
K
D
V
S
V
A
E
L
L
R
E
Site 19
S259
A
E
L
L
R
E
L
S
L
T
K
E
E
E
L
Site 20
T274
L
F
L
Q
L
P
D
T
L
P
G
Q
P
P
T
Site 21
T281
T
L
P
G
Q
P
P
T
Q
D
I
K
P
I
K
Site 22
T317
K
L
A
E
N
A
C
T
L
A
D
L
T
E
G
Site 23
T374
D
S
R
T
G
E
M
T
V
L
G
H
V
K
H
Site 24
S386
V
K
H
K
L
V
C
S
P
D
F
E
S
L
L
Site 25
S391
V
C
S
P
D
F
E
S
L
L
D
H
K
H
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation