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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PKCb
Full Name:
Protein kinase C beta type
Alias:
EC 2.7.11.13; Kinase PKC-beta; KPCB; PKC II; PKC-B; PKC-beta; PKC-II; PRKCB; PRKCB1; PRKCB2; Protein kinase C, beta; Protein kinase C, beta type
Type:
EC 2.7.11.13; Protein kinase, Ser/Thr (non-receptor); AGC group; PKC family; Alpha subfamily
Mass (Da):
76869
Number AA:
670
UniProt ID:
P05771
International Prot ID:
IPI00010466
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0019898
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005509
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0042953
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Protein-serine kinase C beta 1 pan-specific antibody AB-NK133-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK133-2#Protein-serine kinase C beta 1 S661 phosphosite-specific antibody AB-PK765#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK765#Protein-serine kinase C beta 1 T500 phosphosite-specific antibody AB-PK766#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK766#CREB1 (123-135) KinSub - cyclic-AMP response element binding protein-1 (K123-R135, human) peptide; Crebtide protein kinase substrate peptide - Powder PE-01ACP95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ACP95#PKCtide KinSub - Protein kinase C peptide substrate - Powder PE-01ADL95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ADL95#Syntide-2 KinSub - Syntide-2 protein kinase substrate peptide - Powder PE-01AQB95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AQB95#PKCA/BSubtide - PKCa (PRKCA) protein kinase substrate peptide - Powder PE-01BIR95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BIR95#Protein-serine kinase C beta 1 (A658-N664, human) pS661 phosphopeptide - Powder PE-04AOV99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AOV99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
P
A
A
G
P
P
P
S
E
G
E
E
S
T
V
Site 2
S16
P
P
S
E
G
E
E
S
T
V
R
F
A
R
K
Site 3
T17
P
S
E
G
E
E
S
T
V
R
F
A
R
K
G
Site 4
T48
A
R
F
F
K
Q
P
T
F
C
S
H
C
T
D
Site 5
T83
K
R
C
H
E
F
V
T
F
S
C
P
G
A
D
Site 6
S95
G
A
D
K
G
P
A
S
D
D
P
R
S
K
H
Site 7
S100
P
A
S
D
D
P
R
S
K
H
K
F
K
I
H
Site 8
T108
K
H
K
F
K
I
H
T
Y
S
S
P
T
F
C
Site 9
Y109
H
K
F
K
I
H
T
Y
S
S
P
T
F
C
D
Site 10
S149
R
C
V
M
N
V
P
S
L
C
G
T
D
H
T
Site 11
T153
N
V
P
S
L
C
G
T
D
H
T
E
R
R
G
Site 12
T156
S
L
C
G
T
D
H
T
E
R
R
G
R
I
Y
Site 13
Y163
T
E
R
R
G
R
I
Y
I
Q
A
H
I
D
R
Site 14
S192
P
M
D
P
N
G
L
S
D
P
Y
V
K
L
K
Site 15
Y195
P
N
G
L
S
D
P
Y
V
K
L
K
L
I
P
Site 16
S206
K
L
I
P
D
P
K
S
E
S
K
Q
K
T
K
Site 17
S208
I
P
D
P
K
S
E
S
K
Q
K
T
K
T
I
Site 18
T212
K
S
E
S
K
Q
K
T
K
T
I
K
C
S
L
Site 19
T214
E
S
K
Q
K
T
K
T
I
K
C
S
L
N
P
Site 20
T226
L
N
P
E
W
N
E
T
F
R
F
Q
L
K
E
Site 21
S234
F
R
F
Q
L
K
E
S
D
K
D
R
R
L
S
Site 22
S241
S
D
K
D
R
R
L
S
V
E
I
W
D
W
D
Site 23
S258
S
R
N
D
F
M
G
S
L
S
F
G
I
S
E
Site 24
S260
N
D
F
M
G
S
L
S
F
G
I
S
E
L
Q
Site 25
S279
D
G
W
F
K
L
L
S
Q
E
E
G
E
Y
F
Site 26
Y285
L
S
Q
E
E
G
E
Y
F
N
V
P
V
P
P
Site 27
S311
K
F
E
R
A
K
I
S
Q
G
T
K
V
P
E
Site 28
T314
R
A
K
I
S
Q
G
T
K
V
P
E
E
K
T
Site 29
T322
P
E
E
K
T
T
N
T
V
S
K
F
D
N
N
Site 30
T324
P
E
E
K
T
T
N
T
V
S
K
F
D
N
N
Site 31
S359
S
F
G
K
V
M
L
S
E
R
K
G
T
D
E
Site 32
T364
M
L
S
E
R
K
G
T
D
E
L
Y
A
V
K
Site 33
Y368
R
K
G
T
D
E
L
Y
A
V
K
I
L
K
K
Site 34
T404
P
G
K
P
P
F
L
T
Q
L
H
S
C
F
Q
Site 35
T412
Q
L
H
S
C
F
Q
T
M
D
R
L
Y
F
V
Site 36
Y417
F
Q
T
M
D
R
L
Y
F
V
M
E
Y
V
N
Site 37
Y422
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Site 38
Y430
V
N
G
G
D
L
M
Y
H
I
Q
Q
V
G
R
Site 39
S476
L
D
N
V
M
L
D
S
E
G
H
I
K
I
A
Site 40
T497
E
N
I
W
D
G
V
T
T
K
T
F
C
G
T
Site 41
T498
N
I
W
D
G
V
T
T
K
T
F
C
G
T
P
Site 42
T500
W
D
G
V
T
T
K
T
F
C
G
T
P
D
Y
Protein-serine kinase C beta 1 T500 phosphosite-specific antibody AB-PK766#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK766#Protein-serine kinase C beta 1 (T497-G503, human) pT500 phosphopeptide - Powder PE-04AOT99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AOT99
Site 43
T504
T
T
K
T
F
C
G
T
P
D
Y
I
A
P
E
Site 44
Y507
T
F
C
G
T
P
D
Y
I
A
P
E
I
I
A
Site 45
Y515
I
A
P
E
I
I
A
Y
Q
P
Y
G
K
S
V
Site 46
Y518
E
I
I
A
Y
Q
P
Y
G
K
S
V
D
W
W
Site 47
S552
D
E
D
E
L
F
Q
S
I
M
E
H
N
V
A
Site 48
Y560
I
M
E
H
N
V
A
Y
P
K
S
M
S
K
E
Site 49
S563
H
N
V
A
Y
P
K
S
M
S
K
E
A
V
A
Site 50
T577
A
I
C
K
G
L
M
T
K
H
P
G
K
R
L
Site 51
Y617
R
K
E
I
Q
P
P
Y
K
P
K
A
R
D
K
Site 52
T627
K
A
R
D
K
R
D
T
S
N
F
D
K
E
F
Site 53
S628
A
R
D
K
R
D
T
S
N
F
D
K
E
F
T
Site 54
T635
S
N
F
D
K
E
F
T
R
Q
P
V
E
L
T
Site 55
T642
T
R
Q
P
V
E
L
T
P
T
D
K
L
F
I
Site 56
T644
Q
P
V
E
L
T
P
T
D
K
L
F
I
M
N
Site 57
S661
Q
N
E
F
A
G
F
S
Y
T
N
P
E
F
V
Protein-serine kinase C beta 1 S661 phosphosite-specific antibody AB-PK765#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK765#Protein-serine kinase C beta 1 (A658-N664, human) pS661 phosphopeptide - Powder PE-04AOV99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AOV99
Site 58
Y662
N
E
F
A
G
F
S
Y
T
N
P
E
F
V
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation