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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UROD
Full Name:
Uroporphyrinogen decarboxylase
Alias:
DCUP; PCT; UPD; URO-D
Type:
Lyase; EC 4.1.1.37; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll
Mass (Da):
40787
Number AA:
367
UniProt ID:
P06132
International Prot ID:
IPI00301489
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0004853
PhosphoSite+
KinaseNET
Biological Process:
GO:0006783
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
F
P
E
L
K
N
D
T
F
L
R
A
A
W
G
Site 2
Y30
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Site 3
Y42
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
Site 4
T49
Y
L
P
E
F
R
E
T
R
A
A
Q
D
F
F
Site 5
S57
R
A
A
Q
D
F
F
S
T
C
R
S
P
E
A
Site 6
T58
A
A
Q
D
F
F
S
T
C
R
S
P
E
A
C
Site 7
S61
D
F
F
S
T
C
R
S
P
E
A
C
C
E
L
Site 8
T69
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
Site 9
S107
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
Site 10
S129
R
D
P
E
V
V
A
S
E
L
G
Y
V
F
Q
Site 11
Y133
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
Site 12
T139
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
Site 13
T141
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
R
Site 14
S171
Y
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
Site 15
Y182
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Site 16
S188
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
Site 17
S219
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Site 18
Y236
F
N
K
F
A
L
P
Y
I
R
D
V
A
K
Q
Site 19
Y277
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
Site 20
T285
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
Site 21
T298
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
Site 22
Y311
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Site 23
S313
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
Site 24
Y333
D
D
F
G
P
H
R
Y
I
A
N
L
G
H
G
Site 25
Y342
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation