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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BCHE
Full Name:
Cholinesterase
Alias:
Acylcholine acylhydrolase;Butyrylcholine esterase;Choline esterase II;Pseudocholinesterase
Type:
Mass (Da):
68418
Number AA:
602
UniProt ID:
P06276
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S76
L
R
F
K
K
P
Q
S
L
T
K
W
S
D
I
Site 2
T114
S
E
M
W
N
P
N
T
D
L
S
E
D
C
L
Site 3
T150
G
G
G
F
Q
T
G
T
S
S
L
H
V
Y
D
Site 4
S151
G
G
F
Q
T
G
T
S
S
L
H
V
Y
D
G
Site 5
S152
G
F
Q
T
G
T
S
S
L
H
V
Y
D
G
K
Site 6
Y156
G
T
S
S
L
H
V
Y
D
G
K
F
L
A
R
Site 7
Y174
V
I
V
V
S
M
N
Y
R
V
G
A
L
G
F
Site 8
S219
A
F
G
G
N
P
K
S
V
T
L
F
G
E
S
Site 9
T221
G
G
N
P
K
S
V
T
L
F
G
E
S
A
G
Site 10
S226
S
V
T
L
F
G
E
S
A
G
A
A
S
V
S
Site 11
S252
F
T
R
A
I
L
Q
S
G
S
F
N
A
P
W
Site 12
Y265
P
W
A
V
T
S
L
Y
E
A
R
N
R
T
L
Site 13
T271
L
Y
E
A
R
N
R
T
L
N
L
A
K
L
T
Site 14
S371
G
F
S
K
D
N
N
S
I
I
T
R
K
E
F
Site 15
Y448
G
N
N
A
F
F
Y
Y
F
E
H
R
S
S
K
Site 16
Y484
P
L
E
R
R
D
N
Y
T
K
A
E
E
I
L
Site 17
T485
L
E
R
R
D
N
Y
T
K
A
E
E
I
L
S
Site 18
S492
T
K
A
E
E
I
L
S
R
S
I
V
K
R
W
Site 19
S494
A
E
E
I
L
S
R
S
I
V
K
R
W
A
N
Site 20
Y505
R
W
A
N
F
A
K
Y
G
N
P
N
E
T
Q
Site 21
T511
K
Y
G
N
P
N
E
T
Q
N
N
S
T
S
W
Site 22
S515
P
N
E
T
Q
N
N
S
T
S
W
P
V
F
K
Site 23
S517
E
T
Q
N
N
S
T
S
W
P
V
F
K
S
T
Site 24
S523
T
S
W
P
V
F
K
S
T
E
Q
K
Y
L
T
Site 25
T524
S
W
P
V
F
K
S
T
E
Q
K
Y
L
T
L
Site 26
Y528
F
K
S
T
E
Q
K
Y
L
T
L
N
T
E
S
Site 27
T530
S
T
E
Q
K
Y
L
T
L
N
T
E
S
T
R
Site 28
S535
Y
L
T
L
N
T
E
S
T
R
I
M
T
K
L
Site 29
T540
T
E
S
T
R
I
M
T
K
L
R
A
Q
Q
C
Site 30
Y592
W
K
N
Q
F
N
D
Y
T
S
K
K
E
S
C
Site 31
T593
K
N
Q
F
N
D
Y
T
S
K
K
E
S
C
V
Site 32
S594
N
Q
F
N
D
Y
T
S
K
K
E
S
C
V
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation