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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GLA
Full Name:
Alpha-galactosidase A
Alias:
AGAL; agalsidase alfa; alpha-D-galactosidase A; alpha-D-galactoside galactohydrolase; alpha-galactosidase A; GALA; galactosidase, alpha; melibiase
Type:
Lipid Metabolism - glycerolipid; Hydrolase; Glycan Metabolism - glycosphingolipid biosynthesis - globo series; Carbohydrate Metabolism - galactose; Lipid Metabolism - sphingolipid; EC 3.2.1.22
Mass (Da):
48767
Number AA:
429
UniProt ID:
P06280
International Prot ID:
IPI00025869
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005576
GO:0005764
Uniprot
OncoNet
Molecular Function:
GO:0004557
GO:0043169
GO:0042803
PhosphoSite+
KinaseNET
Biological Process:
GO:0046479
GO:0046477
GO:0045019
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
L
R
F
L
A
L
V
S
W
D
I
P
G
A
R
Site 2
T39
L
D
N
G
L
A
R
T
P
T
M
G
W
L
H
Site 3
S62
D
C
Q
E
E
P
D
S
C
I
S
E
K
L
F
Site 4
S78
E
M
A
E
L
M
V
S
E
G
W
K
D
A
G
Site 5
Y86
E
G
W
K
D
A
G
Y
E
Y
L
C
I
D
D
Site 6
S102
W
M
A
P
Q
R
D
S
E
G
R
L
Q
A
D
Site 7
Y123
G
I
R
Q
L
A
N
Y
V
H
S
K
G
L
K
Site 8
Y134
K
G
L
K
L
G
I
Y
A
D
V
G
N
K
T
Site 9
T141
Y
A
D
V
G
N
K
T
C
A
G
F
P
G
S
Site 10
Y152
F
P
G
S
F
G
Y
Y
D
I
D
A
Q
T
F
Site 11
Y184
L
E
N
L
A
D
G
Y
K
H
M
S
L
A
L
Site 12
S188
A
D
G
Y
K
H
M
S
L
A
L
N
R
T
G
Site 13
T194
M
S
L
A
L
N
R
T
G
R
S
I
V
Y
S
Site 14
Y200
R
T
G
R
S
I
V
Y
S
C
E
W
P
L
Y
Site 15
S235
N
F
A
D
I
D
D
S
W
K
S
I
K
S
I
Site 16
S241
D
S
W
K
S
I
K
S
I
L
D
W
T
S
F
Site 17
S247
K
S
I
L
D
W
T
S
F
N
Q
E
R
I
V
Site 18
S304
S
N
D
L
R
H
I
S
P
Q
A
K
A
L
L
Site 19
Y329
D
P
L
G
K
Q
G
Y
Q
L
R
Q
G
D
N
Site 20
S364
Q
E
I
G
G
P
R
S
Y
T
I
A
V
A
S
Site 21
S371
S
Y
T
I
A
V
A
S
L
G
K
G
V
A
C
Site 22
Y397
V
K
R
K
L
G
F
Y
E
W
T
S
R
L
R
Site 23
T400
K
L
G
F
Y
E
W
T
S
R
L
R
S
H
I
Site 24
S405
E
W
T
S
R
L
R
S
H
I
N
P
T
G
T
Site 25
T412
S
H
I
N
P
T
G
T
V
L
L
Q
L
E
N
Site 26
T420
V
L
L
Q
L
E
N
T
M
Q
M
S
L
K
D
Site 27
S424
L
E
N
T
M
Q
M
S
L
K
D
L
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation