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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
C2
Full Name:
Complement C2
Alias:
C3/C5 convertase
Type:
Mass (Da):
83268
Number AA:
752
UniProt ID:
P06681
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
L
Y
P
G
L
A
D
S
A
P
S
C
P
Q
N
Site 2
T34
N
V
N
I
S
G
G
T
F
T
L
S
H
G
W
Site 3
T36
N
I
S
G
G
T
F
T
L
S
H
G
W
A
P
Site 4
S38
S
G
G
T
F
T
L
S
H
G
W
A
P
G
S
Site 5
S45
S
H
G
W
A
P
G
S
L
L
T
Y
S
C
P
Site 6
S50
P
G
S
L
L
T
Y
S
C
P
Q
G
L
Y
P
Site 7
Y56
Y
S
C
P
Q
G
L
Y
P
S
P
A
S
R
L
Site 8
S58
C
P
Q
G
L
Y
P
S
P
A
S
R
L
C
K
Site 9
S61
G
L
Y
P
S
P
A
S
R
L
C
K
S
S
G
Site 10
S67
A
S
R
L
C
K
S
S
G
Q
W
Q
T
P
G
Site 11
T72
K
S
S
G
Q
W
Q
T
P
G
A
T
R
S
L
Site 12
S78
Q
T
P
G
A
T
R
S
L
S
K
A
V
C
K
Site 13
S80
P
G
A
T
R
S
L
S
K
A
V
C
K
P
V
Site 14
Y100
V
S
F
E
N
G
I
Y
T
P
R
L
G
S
Y
Site 15
T101
S
F
E
N
G
I
Y
T
P
R
L
G
S
Y
P
Site 16
S106
I
Y
T
P
R
L
G
S
Y
P
V
G
G
N
V
Site 17
Y107
Y
T
P
R
L
G
S
Y
P
V
G
G
N
V
S
Site 18
S114
Y
P
V
G
G
N
V
S
F
E
C
E
D
G
F
Site 19
S126
D
G
F
I
L
R
G
S
P
V
R
Q
C
R
P
Site 20
S157
H
C
P
N
P
G
I
S
L
G
A
V
R
T
G
Site 21
Y175
G
H
G
D
K
V
R
Y
R
C
S
S
N
L
V
Site 22
S178
D
K
V
R
Y
R
C
S
S
N
L
V
L
T
G
Site 23
S179
K
V
R
Y
R
C
S
S
N
L
V
L
T
G
S
Site 24
T184
C
S
S
N
L
V
L
T
G
S
S
E
R
E
C
Site 25
S186
S
N
L
V
L
T
G
S
S
E
R
E
C
Q
G
Site 26
S187
N
L
V
L
T
G
S
S
E
R
E
C
Q
G
N
Site 27
Y208
E
P
I
C
R
Q
P
Y
S
Y
D
F
P
E
D
Site 28
S209
P
I
C
R
Q
P
Y
S
Y
D
F
P
E
D
V
Site 29
Y210
I
C
R
Q
P
Y
S
Y
D
F
P
E
D
V
A
Site 30
S240
P
T
Q
K
T
K
E
S
L
G
R
K
I
Q
I
Site 31
S250
R
K
I
Q
I
Q
R
S
G
H
L
N
L
Y
L
Site 32
Y256
R
S
G
H
L
N
L
Y
L
L
L
D
C
S
Q
Site 33
S262
L
Y
L
L
L
D
C
S
Q
S
V
S
E
N
D
Site 34
S307
S
E
P
K
V
L
M
S
V
L
N
D
N
S
R
Site 35
T317
N
D
N
S
R
D
M
T
E
V
I
S
S
L
E
Site 36
S322
D
M
T
E
V
I
S
S
L
E
N
A
N
Y
K
Site 37
Y328
S
S
L
E
N
A
N
Y
K
D
H
E
N
G
T
Site 38
Y340
N
G
T
G
T
N
T
Y
A
A
L
N
S
V
Y
Site 39
T361
M
R
L
L
G
M
E
T
M
A
W
Q
E
I
R
Site 40
T375
R
H
A
I
I
L
L
T
D
G
K
S
N
M
G
Site 41
S379
I
L
L
T
D
G
K
S
N
M
G
G
S
P
K
Site 42
S384
G
K
S
N
M
G
G
S
P
K
T
A
V
D
H
Site 43
T387
N
M
G
G
S
P
K
T
A
V
D
H
I
R
E
Site 44
Y405
I
N
Q
K
R
N
D
Y
L
D
I
Y
A
I
G
Site 45
Y409
R
N
D
Y
L
D
I
Y
A
I
G
V
G
K
L
Site 46
S428
R
E
L
N
E
L
G
S
K
K
D
G
E
R
H
Site 47
S469
I
C
G
V
G
N
M
S
A
N
A
S
D
Q
E
Site 48
S473
G
N
M
S
A
N
A
S
D
Q
E
R
T
P
W
Site 49
T478
N
A
S
D
Q
E
R
T
P
W
H
V
T
I
K
Site 50
T483
E
R
T
P
W
H
V
T
I
K
P
K
S
Q
E
Site 51
S488
H
V
T
I
K
P
K
S
Q
E
T
C
R
G
A
Site 52
T491
I
K
P
K
S
Q
E
T
C
R
G
A
L
I
S
Site 53
S527
V
N
V
G
D
P
K
S
Q
W
G
K
E
F
L
Site 54
S598
A
L
R
R
P
Q
G
S
T
C
R
D
H
E
N
Site 55
T599
L
R
R
P
Q
G
S
T
C
R
D
H
E
N
E
Site 56
S612
N
E
L
L
N
K
Q
S
V
P
A
H
F
V
A
Site 57
S643
T
S
C
A
E
V
V
S
Q
E
K
T
M
F
P
Site 58
T647
E
V
V
S
Q
E
K
T
M
F
P
N
L
T
D
Site 59
T653
K
T
M
F
P
N
L
T
D
V
R
E
V
V
T
Site 60
T660
T
D
V
R
E
V
V
T
D
Q
F
L
C
S
G
Site 61
S666
V
T
D
Q
F
L
C
S
G
T
Q
E
D
E
S
Site 62
T668
D
Q
F
L
C
S
G
T
Q
E
D
E
S
P
C
Site 63
S673
S
G
T
Q
E
D
E
S
P
C
K
G
E
S
G
Site 64
S708
L
Y
N
P
C
L
G
S
A
D
K
N
S
R
K
Site 65
S713
L
G
S
A
D
K
N
S
R
K
R
A
P
R
S
Site 66
S720
S
R
K
R
A
P
R
S
K
V
P
P
P
R
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation