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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
eIF4E
Full Name:
Eukaryotic translation initiation factor 4E
Alias:
eIF-4F 25 kDa subunit;mRNA cap-binding protein
Type:
Protein synthesis protein
Mass (Da):
25097
Number AA:
217
UniProt ID:
P06730
International Prot ID:
IPI00027485
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0016281
Uniprot
OncoNet
Molecular Function:
GO:0000339
GO:0005515
GO:0003743
PhosphoSite+
KinaseNET
Biological Process:
GO:0044419
GO:0006417
GO:0006413
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T3
_
_
_
_
_
M
A
T
V
E
P
E
T
T
P
Site 2
T9
A
T
V
E
P
E
T
T
P
T
P
N
P
P
T
Site 3
T11
V
E
P
E
T
T
P
T
P
N
P
P
T
T
E
Site 4
T16
T
P
T
P
N
P
P
T
T
E
E
E
K
T
E
Site 5
T17
P
T
P
N
P
P
T
T
E
E
E
K
T
E
S
Site 6
T22
P
T
T
E
E
E
K
T
E
S
N
Q
E
V
A
Site 7
S24
T
E
E
E
K
T
E
S
N
Q
E
V
A
N
P
Site 8
S53
W
F
F
K
N
D
K
S
K
T
W
Q
A
N
L
Site 9
T55
F
K
N
D
K
S
K
T
W
Q
A
N
L
R
L
Site 10
S64
Q
A
N
L
R
L
I
S
K
F
D
T
V
E
D
Site 11
Y76
V
E
D
F
W
A
L
Y
N
H
I
Q
L
S
S
Site 12
Y91
N
L
M
P
G
C
D
Y
S
L
F
K
D
G
I
Site 13
S92
L
M
P
G
C
D
Y
S
L
F
K
D
G
I
E
Site 14
T116
R
G
G
R
W
L
I
T
L
N
K
Q
Q
R
R
Site 15
S124
L
N
K
Q
Q
R
R
S
D
L
D
R
F
W
L
Site 16
S141
L
L
C
L
I
G
E
S
F
D
D
Y
S
D
D
Site 17
Y145
I
G
E
S
F
D
D
Y
S
D
D
V
C
G
A
Site 18
S146
G
E
S
F
D
D
Y
S
D
D
V
C
G
A
V
Site 19
Y183
V
T
H
I
G
R
V
Y
K
E
R
L
G
L
P
Site 20
T203
G
Y
Q
S
H
A
D
T
A
T
K
S
G
S
T
Site 21
T205
Q
S
H
A
D
T
A
T
K
S
G
S
T
T
K
Site 22
S207
H
A
D
T
A
T
K
S
G
S
T
T
K
N
R
Site 23
S209
D
T
A
T
K
S
G
S
T
T
K
N
R
F
V
Site 24
T210
T
A
T
K
S
G
S
T
T
K
N
R
F
V
V
Site 25
T211
A
T
K
S
G
S
T
T
K
N
R
F
V
V
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation