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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLB
Full Name:
DNA polymerase beta
Alias:
DNA pol beta; DNA polymerase beta subunit; DPOLB; polymerase (DNA directed) beta; polymerase (DNA directed), beta
Type:
Transferase; DNA replication; EC 2.7.7.7; Lyase; DNA repair; EC 4.2.99.-
Mass (Da):
Number AA:
UniProt ID:
P06746
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005654
GO:0005876
Uniprot
OncoNet
Molecular Function:
GO:0003887
GO:0019899
GO:0016829
PhosphoSite+
KinaseNET
Biological Process:
GO:0006261
GO:0006284
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
G
G
I
T
D
M
L
T
E
L
A
N
F
E
K
Site 2
Y36
V
S
Q
A
I
H
K
Y
N
A
Y
R
K
A
A
Site 3
Y39
A
I
H
K
Y
N
A
Y
R
K
A
A
S
V
I
Site 4
Y49
A
A
S
V
I
A
K
Y
P
H
K
I
K
S
G
Site 5
T79
K
I
D
E
F
L
A
T
G
K
L
R
K
L
E
Site 6
T93
E
K
I
R
Q
D
D
T
S
S
S
I
N
F
L
Site 7
S94
K
I
R
Q
D
D
T
S
S
S
I
N
F
L
T
Site 8
S95
I
R
Q
D
D
T
S
S
S
I
N
F
L
T
R
Site 9
S96
R
Q
D
D
T
S
S
S
I
N
F
L
T
R
V
Site 10
S109
R
V
S
G
I
G
P
S
A
A
R
K
F
V
D
Site 11
T121
F
V
D
E
G
I
K
T
L
E
D
L
R
K
N
Site 12
Y142
H
Q
R
I
G
L
K
Y
F
G
D
F
E
K
R
Site 13
T176
V
D
S
E
Y
I
A
T
V
C
G
S
F
R
R
Site 14
S180
Y
I
A
T
V
C
G
S
F
R
R
G
A
E
S
Site 15
S187
S
F
R
R
G
A
E
S
S
G
D
M
D
V
L
Site 16
S188
F
R
R
G
A
E
S
S
G
D
M
D
V
L
L
Site 17
T196
G
D
M
D
V
L
L
T
H
P
S
F
T
S
E
Site 18
S199
D
V
L
L
T
H
P
S
F
T
S
E
S
T
K
Site 19
S202
L
T
H
P
S
F
T
S
E
S
T
K
Q
P
K
Site 20
T227
K
V
H
F
I
T
D
T
L
S
K
G
E
T
K
Site 21
S229
H
F
I
T
D
T
L
S
K
G
E
T
K
F
M
Site 22
T233
D
T
L
S
K
G
E
T
K
F
M
G
V
C
Q
Site 23
S243
M
G
V
C
Q
L
P
S
K
N
D
E
K
E
Y
Site 24
Y250
S
K
N
D
E
K
E
Y
P
H
R
R
I
D
I
Site 25
Y265
R
L
I
P
K
D
Q
Y
Y
C
G
V
L
Y
F
Site 26
T292
H
A
L
E
K
G
F
T
I
N
E
Y
T
I
R
Site 27
Y296
K
G
F
T
I
N
E
Y
T
I
R
P
L
G
V
Site 28
Y322
S
E
K
D
I
F
D
Y
I
Q
W
K
Y
R
E
Site 29
Y327
F
D
Y
I
Q
W
K
Y
R
E
P
K
D
R
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation