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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HEXA
Full Name:
Beta-hexosaminidase subunit alpha
Alias:
N-acetyl-beta-glucosaminidase
Type:
Mass (Da):
60671
Number AA:
529
UniProt ID:
P06865
International Prot ID:
IPI00027851
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000323
GO:0005764
GO:0005773
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004553
GO:0004563
PhosphoSite+
KinaseNET
Biological Process:
GO:0000003
GO:0001501
GO:0001573
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T21
A
A
F
A
G
R
A
T
A
L
W
P
W
P
Q
Site 2
Y37
F
Q
T
S
D
Q
R
Y
V
L
Y
P
N
N
F
Site 3
Y40
S
D
Q
R
Y
V
L
Y
P
N
N
F
Q
F
Q
Site 4
Y48
P
N
N
F
Q
F
Q
Y
D
V
S
S
A
A
Q
Site 5
S51
F
Q
F
Q
Y
D
V
S
S
A
A
Q
P
G
C
Site 6
S52
Q
F
Q
Y
D
V
S
S
A
A
Q
P
G
C
S
Site 7
S75
Y
R
D
L
L
F
G
S
G
S
W
P
R
P
Y
Site 8
S77
D
L
L
F
G
S
G
S
W
P
R
P
Y
L
T
Site 9
Y82
S
G
S
W
P
R
P
Y
L
T
G
K
R
H
T
Site 10
T84
S
W
P
R
P
Y
L
T
G
K
R
H
T
L
E
Site 11
T89
Y
L
T
G
K
R
H
T
L
E
K
N
V
L
V
Site 12
T109
P
G
C
N
Q
L
P
T
L
E
S
V
E
N
Y
Site 13
S112
N
Q
L
P
T
L
E
S
V
E
N
Y
T
L
T
Site 14
T119
S
V
E
N
Y
T
L
T
I
N
D
D
Q
C
L
Site 15
S143
L
R
G
L
E
T
F
S
Q
L
V
W
K
S
A
Site 16
T153
V
W
K
S
A
E
G
T
F
F
I
N
K
T
E
Site 17
T159
G
T
F
F
I
N
K
T
E
I
E
D
F
P
R
Site 18
T176
H
R
G
L
L
L
D
T
S
R
H
Y
L
P
L
Site 19
S177
R
G
L
L
L
D
T
S
R
H
Y
L
P
L
S
Site 20
S184
S
R
H
Y
L
P
L
S
S
I
L
D
T
L
D
Site 21
S210
W
H
L
V
D
D
P
S
F
P
Y
E
S
F
T
Site 22
Y213
V
D
D
P
S
F
P
Y
E
S
F
T
F
P
E
Site 23
S215
D
P
S
F
P
Y
E
S
F
T
F
P
E
L
M
Site 24
T217
S
F
P
Y
E
S
F
T
F
P
E
L
M
R
K
Site 25
S226
P
E
L
M
R
K
G
S
Y
N
P
V
T
H
I
Site 26
Y227
E
L
M
R
K
G
S
Y
N
P
V
T
H
I
Y
Site 27
T231
K
G
S
Y
N
P
V
T
H
I
Y
T
A
Q
D
Site 28
Y245
D
V
K
E
V
I
E
Y
A
R
L
R
G
I
R
Site 29
T259
R
V
L
A
E
F
D
T
P
G
H
T
L
S
W
Site 30
T263
E
F
D
T
P
G
H
T
L
S
W
G
P
G
I
Site 31
S265
D
T
P
G
H
T
L
S
W
G
P
G
I
P
G
Site 32
T275
P
G
I
P
G
L
L
T
P
C
Y
S
G
S
E
Site 33
Y278
P
G
L
L
T
P
C
Y
S
G
S
E
P
S
G
Site 34
S279
G
L
L
T
P
C
Y
S
G
S
E
P
S
G
T
Site 35
S281
L
T
P
C
Y
S
G
S
E
P
S
G
T
F
G
Site 36
T286
S
G
S
E
P
S
G
T
F
G
P
V
N
P
S
Site 37
S293
T
F
G
P
V
N
P
S
L
N
N
T
Y
E
F
Site 38
T297
V
N
P
S
L
N
N
T
Y
E
F
M
S
T
F
Site 39
Y298
N
P
S
L
N
N
T
Y
E
F
M
S
T
F
F
Site 40
T303
N
T
Y
E
F
M
S
T
F
F
L
E
V
S
S
Site 41
Y316
S
S
V
F
P
D
F
Y
L
H
L
G
G
D
E
Site 42
S353
E
D
F
K
Q
L
E
S
F
Y
I
Q
T
L
L
Site 43
T387
K
V
K
I
Q
P
D
T
I
I
Q
V
W
R
E
Site 44
Y435
G
P
D
W
K
D
F
Y
V
V
E
P
L
A
F
Site 45
T445
E
P
L
A
F
E
G
T
P
E
Q
K
A
L
V
Site 46
Y463
E
A
C
M
W
G
E
Y
V
D
N
T
N
L
V
Site 47
S486
A
V
A
E
R
L
W
S
N
K
L
T
S
D
L
Site 48
T490
R
L
W
S
N
K
L
T
S
D
L
T
F
A
Y
Site 49
S491
L
W
S
N
K
L
T
S
D
L
T
F
A
Y
E
Site 50
T494
N
K
L
T
S
D
L
T
F
A
Y
E
R
L
S
Site 51
Y497
T
S
D
L
T
F
A
Y
E
R
L
S
H
F
R
Site 52
S501
T
F
A
Y
E
R
L
S
H
F
R
C
E
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation