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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EPHX1
Full Name:
Epoxide hydrolase 1
Alias:
EC 3.3.2.9; Epoxide hydratase; HYEP; Microsomal epoxide hydrolase
Type:
Enzyme - Hydrolase
Mass (Da):
52949
Number AA:
455
UniProt ID:
P07099
International Prot ID:
IPI00009896
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000267
GO:0005624
GO:0005626
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004301
GO:0016787
PhosphoSite+
KinaseNET
Biological Process:
GO:0006725
GO:0008152
GO:0009056
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T26
I
S
R
D
K
E
E
T
L
P
L
E
D
G
W
Site 2
T38
D
G
W
W
G
P
G
T
R
S
A
A
R
E
D
Site 3
S40
W
W
G
P
G
T
R
S
A
A
R
E
D
D
S
Site 4
S47
S
A
A
R
E
D
D
S
I
R
P
F
K
V
E
Site 5
T55
I
R
P
F
K
V
E
T
S
D
E
E
I
H
D
Site 6
S56
R
P
F
K
V
E
T
S
D
E
E
I
H
D
L
Site 7
T73
R
I
D
K
F
R
F
T
P
P
L
E
D
S
C
Site 8
Y83
L
E
D
S
C
F
H
Y
G
F
N
S
N
Y
L
Site 9
Y89
H
Y
G
F
N
S
N
Y
L
K
K
V
I
S
Y
Site 10
Y96
Y
L
K
K
V
I
S
Y
W
R
N
E
F
D
W
Site 11
Y113
Q
V
E
I
L
N
R
Y
P
H
F
K
T
K
I
Site 12
Y155
H
G
W
P
G
S
F
Y
E
F
Y
K
I
I
P
Site 13
S173
D
P
K
N
H
G
L
S
D
E
H
V
F
E
V
Site 14
Y188
I
C
P
S
I
P
G
Y
G
F
S
E
A
S
S
Site 15
S191
S
I
P
G
Y
G
F
S
E
A
S
S
K
K
G
Site 16
S195
Y
G
F
S
E
A
S
S
K
K
G
F
N
S
V
Site 17
S201
S
S
K
K
G
F
N
S
V
A
T
A
R
I
F
Site 18
Y209
V
A
T
A
R
I
F
Y
K
L
M
L
R
L
G
Site 19
Y221
R
L
G
F
Q
E
F
Y
I
Q
G
G
D
W
G
Site 20
Y283
E
R
D
V
E
L
L
Y
P
V
K
E
K
V
F
Site 21
Y291
P
V
K
E
K
V
F
Y
S
L
M
R
E
S
G
Site 22
S292
V
K
E
K
V
F
Y
S
L
M
R
E
S
G
Y
Site 23
Y299
S
L
M
R
E
S
G
Y
M
H
I
Q
C
T
K
Site 24
T309
I
Q
C
T
K
P
D
T
V
G
S
A
L
N
D
Site 25
S312
T
K
P
D
T
V
G
S
A
L
N
D
S
P
V
Site 26
T331
Y
I
L
E
K
F
S
T
W
T
N
T
E
F
R
Site 27
T335
K
F
S
T
W
T
N
T
E
F
R
Y
L
E
D
Site 28
Y339
W
T
N
T
E
F
R
Y
L
E
D
G
G
L
E
Site 29
S350
G
G
L
E
R
K
F
S
L
D
D
L
L
T
N
Site 30
Y361
L
L
T
N
V
M
L
Y
W
T
T
G
T
I
I
Site 31
S370
T
T
G
T
I
I
S
S
Q
R
F
Y
K
E
N
Site 32
Y374
I
I
S
S
Q
R
F
Y
K
E
N
L
G
Q
G
Site 33
Y393
K
H
E
R
M
K
V
Y
V
P
T
G
F
S
A
Site 34
T408
F
P
F
E
L
L
H
T
P
E
K
W
V
R
F
Site 35
Y417
E
K
W
V
R
F
K
Y
P
K
L
I
S
Y
S
Site 36
S422
F
K
Y
P
K
L
I
S
Y
S
Y
M
V
R
G
Site 37
Y423
K
Y
P
K
L
I
S
Y
S
Y
M
V
R
G
G
Site 38
Y425
P
K
L
I
S
Y
S
Y
M
V
R
G
G
H
F
Site 39
S450
Q
D
I
R
K
F
L
S
V
L
E
R
Q
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation