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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TH
Full Name:
Tyrosine 3-monooxygenase
Alias:
DYT14; DYT5b; TH isoform 3; TH isoform a; TH-4; TY3H; TYH; Tyrosine 3-hydroxylase; Tyrosine hydroxylase
Type:
Endoplasmic reticulum; Vesicle protein; EC 1.14.16.2; Amino Acid Metabolism - tyrosine; Mitochondrial; Oxidoreductase
Mass (Da):
58600
Number AA:
528
UniProt ID:
P07101
International Prot ID:
IPI00010178
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0009898
GO:0033162
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004511
PhosphoSite+
KinaseNET
Biological Process:
GO:0006585
GO:0048596
GO:0042418
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
P
T
P
D
A
T
T
P
Q
A
K
G
F
R
Site 2
S19
K
G
F
R
R
A
V
S
E
L
D
A
K
Q
A
Site 3
S40
G
Q
G
A
P
G
P
S
L
T
G
S
P
W
P
Site 4
T42
G
A
P
G
P
S
L
T
G
S
P
W
P
G
T
Site 5
S44
P
G
P
S
L
T
G
S
P
W
P
G
T
A
A
Site 6
T49
T
G
S
P
W
P
G
T
A
A
P
A
A
S
Y
Site 7
S55
G
T
A
A
P
A
A
S
Y
T
P
T
P
R
S
Site 8
T57
A
A
P
A
A
S
Y
T
P
T
P
R
S
P
R
Site 9
T59
P
A
A
S
Y
T
P
T
P
R
S
P
R
F
I
Site 10
S62
S
Y
T
P
T
P
R
S
P
R
F
I
G
R
R
Site 11
S71
R
F
I
G
R
R
Q
S
L
I
E
D
A
R
K
Site 12
S93
A
A
A
A
A
V
P
S
E
P
G
D
P
L
E
Site 13
T122
L
L
F
S
P
R
A
T
K
P
S
A
L
S
R
Site 14
S125
S
P
R
A
T
K
P
S
A
L
S
R
A
V
K
Site 15
S128
A
T
K
P
S
A
L
S
R
A
V
K
V
F
E
Site 16
T136
R
A
V
K
V
F
E
T
F
E
A
K
I
H
H
Site 17
Y161
A
G
G
P
H
L
E
Y
F
V
R
L
E
V
R
Site 18
S183
L
S
G
V
R
Q
V
S
E
D
V
R
S
P
A
Site 19
S188
Q
V
S
E
D
V
R
S
P
A
G
P
K
V
P
Site 20
S226
D
L
D
H
P
G
F
S
D
Q
V
Y
R
Q
R
Site 21
Y230
P
G
F
S
D
Q
V
Y
R
Q
R
R
K
L
I
Site 22
Y255
D
P
I
P
R
V
E
Y
T
A
E
E
I
A
T
Site 23
T269
T
W
K
E
V
Y
T
T
L
K
G
L
Y
A
T
Site 24
S293
F
A
L
L
E
R
F
S
G
Y
R
E
D
N
I
Site 25
Y344
R
V
F
Q
C
T
Q
Y
I
R
H
A
S
S
P
Site 26
S349
T
Q
Y
I
R
H
A
S
S
P
M
H
S
P
E
Site 27
S350
Q
Y
I
R
H
A
S
S
P
M
H
S
P
E
P
Site 28
S354
H
A
S
S
P
M
H
S
P
E
P
D
C
C
H
Site 29
T374
V
P
M
L
A
D
R
T
F
A
Q
F
S
Q
D
Site 30
S379
D
R
T
F
A
Q
F
S
Q
D
I
G
L
A
S
Site 31
S386
S
Q
D
I
G
L
A
S
L
G
A
S
D
E
E
Site 32
S390
G
L
A
S
L
G
A
S
D
E
E
I
E
K
L
Site 33
T399
E
E
I
E
K
L
S
T
L
Y
W
F
T
V
E
Site 34
Y419
Q
N
G
E
V
K
A
Y
G
A
G
L
L
S
S
Site 35
S435
G
E
L
L
H
C
L
S
E
E
P
E
I
R
A
Site 36
T457
V
Q
P
Y
Q
D
Q
T
Y
Q
S
V
Y
F
V
Site 37
Y458
Q
P
Y
Q
D
Q
T
Y
Q
S
V
Y
F
V
S
Site 38
Y462
D
Q
T
Y
Q
S
V
Y
F
V
S
E
S
F
S
Site 39
S465
Y
Q
S
V
Y
F
V
S
E
S
F
S
D
A
K
Site 40
S467
S
V
Y
F
V
S
E
S
F
S
D
A
K
D
K
Site 41
S469
Y
F
V
S
E
S
F
S
D
A
K
D
K
L
R
Site 42
Y478
A
K
D
K
L
R
S
Y
A
S
R
I
Q
R
P
Site 43
S480
D
K
L
R
S
Y
A
S
R
I
Q
R
P
F
S
Site 44
S487
S
R
I
Q
R
P
F
S
V
K
F
D
P
Y
T
Site 45
S502
L
A
I
D
V
L
D
S
P
Q
A
V
R
R
S
Site 46
S509
S
P
Q
A
V
R
R
S
L
E
G
V
Q
D
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation