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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NEFM
Full Name:
Neurofilament medium polypeptide
Alias:
160 kDa neurofilament protein; NEF3; Neurofilament 3; Neurofilament triplet M protein; Neurofilament, medium polypeptide; NF-M
Type:
Cytoskeletal protein
Mass (Da):
102472
Number AA:
916
UniProt ID:
P07197
International Prot ID:
IPI00217507
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030424
GO:0005883
Uniprot
OncoNet
Molecular Function:
GO:0005200
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
Y
T
L
D
S
L
G
Site 2
S7
_
M
S
Y
T
L
D
S
L
G
N
P
S
A
Y
Site 3
Y14
S
L
G
N
P
S
A
Y
R
R
V
T
E
T
R
Site 4
T18
P
S
A
Y
R
R
V
T
E
T
R
S
S
F
S
Site 5
T20
A
Y
R
R
V
T
E
T
R
S
S
F
S
R
V
Site 6
S22
R
R
V
T
E
T
R
S
S
F
S
R
V
S
G
Site 7
S23
R
V
T
E
T
R
S
S
F
S
R
V
S
G
S
Site 8
S25
T
E
T
R
S
S
F
S
R
V
S
G
S
P
S
Site 9
S28
R
S
S
F
S
R
V
S
G
S
P
S
S
G
F
Site 10
S30
S
F
S
R
V
S
G
S
P
S
S
G
F
R
S
Site 11
S32
S
R
V
S
G
S
P
S
S
G
F
R
S
Q
S
Site 12
S33
R
V
S
G
S
P
S
S
G
F
R
S
Q
S
W
Site 13
S37
S
P
S
S
G
F
R
S
Q
S
W
S
R
G
S
Site 14
S39
S
S
G
F
R
S
Q
S
W
S
R
G
S
P
S
Site 15
S41
G
F
R
S
Q
S
W
S
R
G
S
P
S
T
V
Site 16
S44
S
Q
S
W
S
R
G
S
P
S
T
V
S
S
S
Site 17
S46
S
W
S
R
G
S
P
S
T
V
S
S
S
Y
K
Site 18
T47
W
S
R
G
S
P
S
T
V
S
S
S
Y
K
R
Site 19
S49
R
G
S
P
S
T
V
S
S
S
Y
K
R
S
M
Site 20
S50
G
S
P
S
T
V
S
S
S
Y
K
R
S
M
L
Site 21
S51
S
P
S
T
V
S
S
S
Y
K
R
S
M
L
A
Site 22
Y52
P
S
T
V
S
S
S
Y
K
R
S
M
L
A
P
Site 23
S55
V
S
S
S
Y
K
R
S
M
L
A
P
R
L
A
Site 24
S65
A
P
R
L
A
Y
S
S
A
M
L
S
S
A
E
Site 25
S69
A
Y
S
S
A
M
L
S
S
A
E
S
S
L
D
Site 26
S70
Y
S
S
A
M
L
S
S
A
E
S
S
L
D
F
Site 27
S73
A
M
L
S
S
A
E
S
S
L
D
F
S
Q
S
Site 28
S74
M
L
S
S
A
E
S
S
L
D
F
S
Q
S
S
Site 29
S78
A
E
S
S
L
D
F
S
Q
S
S
S
L
L
N
Site 30
S80
S
S
L
D
F
S
Q
S
S
S
L
L
N
G
G
Site 31
S81
S
L
D
F
S
Q
S
S
S
L
L
N
G
G
S
Site 32
S82
L
D
F
S
Q
S
S
S
L
L
N
G
G
S
G
Site 33
S88
S
S
L
L
N
G
G
S
G
P
G
G
D
Y
K
Site 34
Y94
G
S
G
P
G
G
D
Y
K
L
S
R
S
N
E
Site 35
S97
P
G
G
D
Y
K
L
S
R
S
N
E
K
E
Q
Site 36
Y115
L
N
D
R
F
A
G
Y
I
E
K
V
H
Y
L
Site 37
Y121
G
Y
I
E
K
V
H
Y
L
E
Q
Q
N
K
E
Site 38
S142
A
L
R
Q
K
Q
A
S
H
A
Q
L
G
D
A
Site 39
Y150
H
A
Q
L
G
D
A
Y
D
Q
E
I
R
E
L
Site 40
T160
E
I
R
E
L
R
A
T
L
E
M
V
N
H
E
Site 41
S175
K
A
Q
V
Q
L
D
S
D
H
L
E
E
D
I
Site 42
T199
E
A
R
L
R
D
D
T
E
A
A
I
R
A
L
Site 43
S214
R
K
D
I
E
E
A
S
L
V
K
V
E
L
D
Site 44
S226
E
L
D
K
K
V
Q
S
L
Q
D
E
V
A
F
Site 45
T255
Q
I
Q
A
S
H
I
T
V
E
R
K
D
Y
L
Site 46
Y261
I
T
V
E
R
K
D
Y
L
K
T
D
I
S
T
Site 47
S267
D
Y
L
K
T
D
I
S
T
A
L
K
E
I
R
Site 48
S275
T
A
L
K
E
I
R
S
Q
L
E
S
H
S
D
Site 49
S279
E
I
R
S
Q
L
E
S
H
S
D
Q
N
M
H
Site 50
S281
R
S
Q
L
E
S
H
S
D
Q
N
M
H
Q
A
Site 51
T300
K
C
R
Y
A
K
L
T
E
A
A
E
Q
N
K
Site 52
S312
Q
N
K
E
A
I
R
S
A
K
E
E
I
A
E
Site 53
Y320
A
K
E
E
I
A
E
Y
R
R
Q
L
Q
S
K
Site 54
S326
E
Y
R
R
Q
L
Q
S
K
S
I
E
L
E
S
Site 55
S328
R
R
Q
L
Q
S
K
S
I
E
L
E
S
V
R
Site 56
S333
S
K
S
I
E
L
E
S
V
R
G
T
K
E
S
Site 57
T337
E
L
E
S
V
R
G
T
K
E
S
L
E
R
Q
Site 58
S340
S
V
R
G
T
K
E
S
L
E
R
Q
L
S
D
Site 59
S346
E
S
L
E
R
Q
L
S
D
I
E
E
R
H
N
Site 60
S357
E
R
H
N
H
D
L
S
S
Y
Q
D
T
I
Q
Site 61
S358
R
H
N
H
D
L
S
S
Y
Q
D
T
I
Q
Q
Site 62
Y359
H
N
H
D
L
S
S
Y
Q
D
T
I
Q
Q
L
Site 63
T362
D
L
S
S
Y
Q
D
T
I
Q
Q
L
E
N
E
Site 64
T373
L
E
N
E
L
R
G
T
K
W
E
M
A
R
H
Site 65
Y384
M
A
R
H
L
R
E
Y
Q
D
L
L
N
V
K
Site 66
Y401
L
D
I
E
I
A
A
Y
R
K
L
L
E
G
E
Site 67
T410
K
L
L
E
G
E
E
T
R
F
S
T
F
A
G
Site 68
S413
E
G
E
E
T
R
F
S
T
F
A
G
S
I
T
Site 69
T414
G
E
E
T
R
F
S
T
F
A
G
S
I
T
G
Site 70
T420
S
T
F
A
G
S
I
T
G
P
L
Y
T
H
R
Site 71
Y424
G
S
I
T
G
P
L
Y
T
H
R
P
P
I
T
Site 72
T425
S
I
T
G
P
L
Y
T
H
R
P
P
I
T
I
Site 73
T431
Y
T
H
R
P
P
I
T
I
S
S
K
I
Q
K
Site 74
S467
T
K
V
E
D
E
K
S
E
M
E
E
A
L
T
Site 75
T474
S
E
M
E
E
A
L
T
A
I
T
E
E
L
A
Site 76
S483
I
T
E
E
L
A
A
S
M
K
E
E
K
K
E
Site 77
S511
E
E
V
A
A
K
K
S
P
V
K
A
T
A
P
Site 78
S545
E
E
D
E
G
A
K
S
D
Q
A
E
E
G
G
Site 79
S553
D
Q
A
E
E
G
G
S
E
K
E
G
S
S
E
Site 80
S558
G
S
E
K
E
G
S
S
E
K
E
E
G
E
Q
Site 81
S559
G
S
E
K
E
G
S
S
E
K
E
E
G
E
Q
Site 82
T571
G
E
Q
E
E
G
E
T
E
A
E
A
E
G
E
Site 83
S592
E
K
K
V
E
E
K
S
E
E
V
A
T
K
E
Site 84
T597
E
K
S
E
E
V
A
T
K
E
E
L
V
A
D
Site 85
S615
E
K
P
E
K
A
K
S
P
V
P
K
S
P
V
Site 86
S620
A
K
S
P
V
P
K
S
P
V
E
E
K
G
K
Site 87
S628
P
V
E
E
K
G
K
S
P
V
P
K
S
P
V
Site 88
S633
G
K
S
P
V
P
K
S
P
V
E
E
K
G
K
Site 89
S667
P
V
E
E
K
G
K
S
P
V
S
K
S
P
V
Site 90
S670
E
K
G
K
S
P
V
S
K
S
P
V
E
E
K
Site 91
S672
G
K
S
P
V
S
K
S
P
V
E
E
K
A
K
Site 92
S680
P
V
E
E
K
A
K
S
P
V
P
K
S
P
V
Site 93
S685
A
K
S
P
V
P
K
S
P
V
E
E
A
K
S
Site 94
S692
S
P
V
E
E
A
K
S
K
A
E
V
G
K
G
Site 95
S736
P
E
K
K
K
A
E
S
P
V
K
E
E
A
V
Site 96
S752
E
V
V
T
I
T
K
S
V
K
V
H
L
E
K
Site 97
S783
K
A
G
G
E
G
G
S
E
E
E
G
S
D
K
Site 98
S788
G
G
S
E
E
E
G
S
D
K
G
A
K
G
S
Site 99
T831
E
E
E
K
G
V
V
T
N
G
L
D
L
S
P
Site 100
S837
V
T
N
G
L
D
L
S
P
A
D
E
K
K
G
Site 101
S848
E
K
K
G
G
D
K
S
E
E
K
V
V
V
T
Site 102
T857
E
K
V
V
V
T
K
T
V
E
K
I
T
S
E
Site 103
S863
K
T
V
E
K
I
T
S
E
G
G
D
G
A
T
Site 104
T870
S
E
G
G
D
G
A
T
K
Y
I
T
K
S
V
Site 105
Y872
G
G
D
G
A
T
K
Y
I
T
K
S
V
T
V
Site 106
S876
A
T
K
Y
I
T
K
S
V
T
V
T
Q
K
V
Site 107
T880
I
T
K
S
V
T
V
T
Q
K
V
E
E
H
E
Site 108
T889
K
V
E
E
H
E
E
T
F
E
E
K
L
V
S
Site 109
S896
T
F
E
E
K
L
V
S
T
K
K
V
E
K
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation