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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PROS1
Full Name:
Vitamin K-dependent protein S
Alias:
Type:
Mass (Da):
75123
Number AA:
676
UniProt ID:
P07225
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
V
S
E
A
N
F
L
S
K
Q
Q
A
S
Q
V
Site 2
S44
V
R
K
R
R
A
N
S
L
L
E
E
T
K
Q
Site 3
Y80
E
N
D
P
E
T
D
Y
F
Y
P
K
Y
L
V
Site 4
Y82
D
P
E
T
D
Y
F
Y
P
K
Y
L
V
C
L
Site 5
Y85
T
D
Y
F
Y
P
K
Y
L
V
C
L
R
S
F
Site 6
T98
S
F
Q
T
G
L
F
T
A
A
R
Q
S
T
N
Site 7
S103
L
F
T
A
A
R
Q
S
T
N
A
Y
P
D
L
Site 8
T104
F
T
A
A
R
Q
S
T
N
A
Y
P
D
L
R
Site 9
Y107
A
R
Q
S
T
N
A
Y
P
D
L
R
S
C
V
Site 10
S122
N
A
I
P
D
Q
C
S
P
L
P
C
N
E
D
Site 11
Y131
L
P
C
N
E
D
G
Y
M
S
C
K
D
G
K
Site 12
S140
S
C
K
D
G
K
A
S
F
T
C
T
C
K
P
Site 13
S206
C
K
D
V
D
E
C
S
L
K
P
S
I
C
G
Site 14
Y234
E
C
P
E
G
Y
R
Y
N
L
K
S
K
S
C
Site 15
S238
G
Y
R
Y
N
L
K
S
K
S
C
E
D
I
D
Site 16
S240
R
Y
N
L
K
S
K
S
C
E
D
I
D
E
C
Site 17
Y259
C
A
Q
L
C
V
N
Y
P
G
G
Y
T
C
Y
Site 18
Y266
Y
P
G
G
Y
T
C
Y
C
D
G
K
K
G
F
Site 19
S281
K
L
A
Q
D
Q
K
S
C
E
V
V
S
V
C
Site 20
Y297
P
L
N
L
D
T
K
Y
E
L
L
Y
L
A
E
Site 21
Y301
D
T
K
Y
E
L
L
Y
L
A
E
Q
F
A
G
Site 22
S321
K
F
R
L
P
E
I
S
R
F
S
A
E
F
D
Site 23
S324
L
P
E
I
S
R
F
S
A
E
F
D
F
R
T
Site 24
T331
S
A
E
F
D
F
R
T
Y
D
S
E
G
V
I
Site 25
Y332
A
E
F
D
F
R
T
Y
D
S
E
G
V
I
L
Site 26
S334
F
D
F
R
T
Y
D
S
E
G
V
I
L
Y
A
Site 27
Y340
D
S
E
G
V
I
L
Y
A
E
S
I
D
H
S
Site 28
S387
N
G
L
W
N
M
V
S
V
E
E
L
E
H
S
Site 29
S394
S
V
E
E
L
E
H
S
I
S
I
K
I
A
K
Site 30
S396
E
E
L
E
H
S
I
S
I
K
I
A
K
E
A
Site 31
Y426
G
L
L
E
T
K
V
Y
F
A
G
F
P
R
K
Site 32
T478
Q
N
K
H
C
L
V
T
V
E
K
G
S
Y
Y
Site 33
S483
L
V
T
V
E
K
G
S
Y
Y
P
G
S
G
I
Site 34
Y484
V
T
V
E
K
G
S
Y
Y
P
G
S
G
I
A
Site 35
Y485
T
V
E
K
G
S
Y
Y
P
G
S
G
I
A
Q
Site 36
S488
K
G
S
Y
Y
P
G
S
G
I
A
Q
F
H
I
Site 37
Y497
I
A
Q
F
H
I
D
Y
N
N
V
S
S
A
E
Site 38
T511
E
G
W
H
V
N
V
T
L
N
I
R
P
S
T
Site 39
S542
F
A
V
S
L
V
D
S
T
S
E
K
S
Q
D
Site 40
S544
V
S
L
V
D
S
T
S
E
K
S
Q
D
I
L
Site 41
S547
V
D
S
T
S
E
K
S
Q
D
I
L
L
S
V
Site 42
S566
I
Y
R
I
Q
A
L
S
L
C
S
D
Q
Q
S
Site 43
S573
S
L
C
S
D
Q
Q
S
H
L
E
F
R
V
N
Site 44
S587
N
R
N
N
L
E
L
S
T
P
L
K
I
E
T
Site 45
T588
R
N
N
L
E
L
S
T
P
L
K
I
E
T
I
Site 46
T630
P
D
V
P
F
S
A
T
P
V
N
A
F
Y
N
Site 47
S656
L
D
L
D
E
A
I
S
K
H
N
D
I
R
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation