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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDIA1
Full Name:
Protein disulfide-isomerase
Alias:
Cellular thyroid hormone binding protein; EC 5.3.4.1; P4HB; p55; PDI; PO4DB; Prolyl 4-hydroxylase beta subunit
Type:
Enzyme - Hydroxylase
Mass (Da):
57116
Number AA:
508
UniProt ID:
P07237
International Prot ID:
IPI00010796
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005793
GO:0009986
GO:0005788
Uniprot
OncoNet
Molecular Function:
GO:0004656
GO:0005515
GO:0003756
PhosphoSite+
KinaseNET
Biological Process:
GO:0045454
GO:0018401
Phosida
TranscriptoNet
STRING
Kinexus Products
Protein disulfide-isomerase pan-specific antibody AB-NN141-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN141-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y43
E
A
L
A
A
H
K
Y
L
L
V
E
F
Y
A
Site 2
Y63
C
K
A
L
A
P
E
Y
A
K
A
A
G
K
L
Site 3
S75
G
K
L
K
A
E
G
S
E
I
R
L
A
K
V
Site 4
T85
R
L
A
K
V
D
A
T
E
E
S
D
L
A
Q
Site 5
Y94
E
S
D
L
A
Q
Q
Y
G
V
R
G
Y
P
T
Site 6
Y99
Q
Q
Y
G
V
R
G
Y
P
T
I
K
F
F
R
Site 7
T101
Y
G
V
R
G
Y
P
T
I
K
F
F
R
N
G
Site 8
T110
K
F
F
R
N
G
D
T
A
S
P
K
E
Y
T
Site 9
S112
F
R
N
G
D
T
A
S
P
K
E
Y
T
A
G
Site 10
Y116
D
T
A
S
P
K
E
Y
T
A
G
R
E
A
D
Site 11
S148
P
D
G
A
A
A
E
S
L
V
E
S
S
E
V
Site 12
S166
G
F
F
K
D
V
E
S
D
S
A
K
Q
F
L
Site 13
S168
F
K
D
V
E
S
D
S
A
K
Q
F
L
Q
A
Site 14
S188
D
I
P
F
G
I
T
S
N
S
D
V
F
S
K
Site 15
S190
P
F
G
I
T
S
N
S
D
V
F
S
K
Y
Q
Site 16
S194
T
S
N
S
D
V
F
S
K
Y
Q
L
D
K
D
Site 17
Y196
N
S
D
V
F
S
K
Y
Q
L
D
K
D
G
V
Site 18
T221
N
N
F
E
G
E
V
T
K
E
N
L
L
D
F
Site 19
S266
L
F
L
P
K
S
V
S
D
Y
D
G
K
L
S
Site 20
Y268
L
P
K
S
V
S
D
Y
D
G
K
L
S
N
F
Site 21
S273
S
D
Y
D
G
K
L
S
N
F
K
T
A
A
E
Site 22
T277
G
K
L
S
N
F
K
T
A
A
E
S
F
K
G
Site 23
S281
N
F
K
T
A
A
E
S
F
K
G
K
I
L
F
Site 24
T325
I
T
L
E
E
E
M
T
K
Y
K
P
E
S
E
Site 25
Y327
L
E
E
E
M
T
K
Y
K
P
E
S
E
E
L
Site 26
T335
K
P
E
S
E
E
L
T
A
E
R
I
T
E
F
Site 27
T340
E
L
T
A
E
R
I
T
E
F
C
H
R
F
L
Site 28
S357
K
I
K
P
H
L
M
S
Q
E
L
P
E
D
W
Site 29
Y393
K
N
V
F
V
E
F
Y
A
P
W
C
G
H
C
Site 30
T453
F
P
A
S
A
D
R
T
V
I
D
Y
N
G
E
Site 31
Y457
A
D
R
T
V
I
D
Y
N
G
E
R
T
L
D
Site 32
S472
G
F
K
K
F
L
E
S
G
G
Q
D
G
A
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation