PhosphoNET

           
Protein Info 
   
Short Name:  CTSD
Full Name:  Cathepsin D
Alias:  CATD; Cathepsin D; CLN10; CPSD; EC 3.4.23.5; MGC2311
Type:  Enzyme, acid protease
Mass (Da):  44552
Number AA:  412
UniProt ID:  P07339
International Prot ID:  IPI00011229
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005576  GO:0005764  GO:0042470 Uniprot OncoNet
Molecular Function:  GO:0004190     PhosphoSite+ KinaseNET
Biological Process:  GO:0008219  GO:0006508   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S31IPLHKFTSIRRTMSE
Site 2T35KFTSIRRTMSEVGGS
Site 3S37TSIRRTMSEVGGSVE
Site 4Y55AKGPVSKYSQAVPAV
Site 5S56KGPVSKYSQAVPAVT
Site 6Y74IPEVLKNYMDAQYYG
Site 7Y79KNYMDAQYYGEIGIG
Site 8Y80NYMDAQYYGEIGIGT
Site 9Y123ACWIHHKYNSDKSST
Site 10S128HKYNSDKSSTYVKNG
Site 11S129KYNSDKSSTYVKNGT
Site 12Y131NSDKSSTYVKNGTSF
Site 13Y142GTSFDIHYGSGSLSG
Site 14S144SFDIHYGSGSLSGYL
Site 15S146DIHYGSGSLSGYLSQ
Site 16S148HYGSGSLSGYLSQDT
Site 17Y150GSGSLSGYLSQDTVS
Site 18S152GSLSGYLSQDTVSVP
Site 19T155SGYLSQDTVSVPCQS
Site 20S157YLSQDTVSVPCQSAS
Site 21Y203DGILGMAYPRISVNN
Site 22S230LVDQNIFSFYLSRDP
Site 23Y232DQNIFSFYLSRDPDA
Site 24S234NIFSFYLSRDPDAQP
Site 25T250GELMLGGTDSKYYKG
Site 26S252LMLGGTDSKYYKGSL
Site 27Y254LGGTDSKYYKGSLSY
Site 28Y255GGTDSKYYKGSLSYL
Site 29S258DSKYYKGSLSYLNVT
Site 30S260KYYKGSLSYLNVTRK
Site 31Y269LNVTRKAYWQVHLDQ
Site 32Y325VPLIQGEYMIPCEKV
Site 33Y347LKLGGKGYKLSPEDY
Site 34S350GGKGYKLSPEDYTLK
Site 35Y354YKLSPEDYTLKVSQA
Site 36T355KLSPEDYTLKVSQAG
Site 37S359EDYTLKVSQAGKTLC
Site 38Y393GDVFIGRYYTVFDRD
Site 39Y394DVFIGRYYTVFDRDN
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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