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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
C8A
Full Name:
Complement component C8 alpha chain
Alias:
Complement component 8 subunit alpha
Type:
Mass (Da):
65163
Number AA:
584
UniProt ID:
P07357
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T33
Q
R
V
R
R
A
A
T
P
A
A
V
T
C
Q
Site 2
Y58
F
P
C
Q
D
K
K
Y
R
H
R
S
L
L
Q
Site 3
S62
D
K
K
Y
R
H
R
S
L
L
Q
P
N
K
F
Site 4
S83
G
D
I
W
D
Q
A
S
C
S
S
S
T
T
C
Site 5
S85
I
W
D
Q
A
S
C
S
S
S
T
T
C
V
R
Site 6
S87
D
Q
A
S
C
S
S
S
T
T
C
V
R
Q
A
Site 7
T89
A
S
C
S
S
S
T
T
C
V
R
Q
A
Q
C
Site 8
S125
D
Q
D
C
L
D
G
S
D
E
D
D
C
E
D
Site 9
S141
R
A
I
D
E
D
C
S
Q
Y
E
P
I
P
G
Site 10
Y143
I
D
E
D
C
S
Q
Y
E
P
I
P
G
S
Q
Site 11
S149
Q
Y
E
P
I
P
G
S
Q
K
A
A
L
G
Y
Site 12
T160
A
L
G
Y
N
I
L
T
Q
E
D
A
Q
S
V
Site 13
S166
L
T
Q
E
D
A
Q
S
V
Y
D
A
S
Y
Y
Site 14
Y168
Q
E
D
A
Q
S
V
Y
D
A
S
Y
Y
G
G
Site 15
Y172
Q
S
V
Y
D
A
S
Y
Y
G
G
Q
C
E
T
Site 16
Y181
G
G
Q
C
E
T
V
Y
N
G
E
W
R
E
L
Site 17
Y190
G
E
W
R
E
L
R
Y
D
S
T
C
E
R
L
Site 18
T193
R
E
L
R
Y
D
S
T
C
E
R
L
Y
Y
G
Site 19
Y198
D
S
T
C
E
R
L
Y
Y
G
D
D
E
K
Y
Site 20
Y199
S
T
C
E
R
L
Y
Y
G
D
D
E
K
Y
F
Site 21
Y205
Y
Y
G
D
D
E
K
Y
F
R
K
P
Y
N
F
Site 22
Y210
E
K
Y
F
R
K
P
Y
N
F
L
K
Y
H
F
Site 23
Y215
K
P
Y
N
F
L
K
Y
H
F
E
A
L
A
D
Site 24
T223
H
F
E
A
L
A
D
T
G
I
S
S
E
F
Y
Site 25
Y230
T
G
I
S
S
E
F
Y
D
N
A
N
D
L
L
Site 26
S238
D
N
A
N
D
L
L
S
K
V
K
K
D
K
S
Site 27
S245
S
K
V
K
K
D
K
S
D
S
F
G
V
T
I
Site 28
S247
V
K
K
D
K
S
D
S
F
G
V
T
I
G
I
Site 29
S270
V
G
V
G
V
S
H
S
Q
D
T
S
F
L
N
Site 30
S274
V
S
H
S
Q
D
T
S
F
L
N
E
L
N
K
Site 31
Y282
F
L
N
E
L
N
K
Y
N
E
K
K
F
I
F
Site 32
T290
N
E
K
K
F
I
F
T
R
I
F
T
K
V
Q
Site 33
S317
L
D
E
G
M
L
Q
S
L
M
E
L
P
D
Q
Site 34
Y325
L
M
E
L
P
D
Q
Y
N
Y
G
M
Y
A
K
Site 35
Y337
Y
A
K
F
I
N
D
Y
G
T
H
Y
I
T
S
Site 36
T339
K
F
I
N
D
Y
G
T
H
Y
I
T
S
G
S
Site 37
Y341
I
N
D
Y
G
T
H
Y
I
T
S
G
S
M
G
Site 38
S364
I
D
K
A
K
M
E
S
L
G
I
T
S
R
D
Site 39
T368
K
M
E
S
L
G
I
T
S
R
D
I
T
T
C
Site 40
Y384
G
G
S
L
G
I
Q
Y
E
D
K
I
N
V
G
Site 41
S395
I
N
V
G
G
G
L
S
G
D
H
C
K
K
F
Site 42
T407
K
K
F
G
G
G
K
T
E
R
A
R
K
A
M
Site 43
S421
M
A
V
E
D
I
I
S
R
V
R
G
G
S
S
Site 44
S427
I
S
R
V
R
G
G
S
S
G
W
S
G
G
L
Site 45
S428
S
R
V
R
G
G
S
S
G
W
S
G
G
L
A
Site 46
S431
R
G
G
S
S
G
W
S
G
G
L
A
Q
N
R
Site 47
S439
G
G
L
A
Q
N
R
S
T
I
T
Y
R
S
W
Site 48
T440
G
L
A
Q
N
R
S
T
I
T
Y
R
S
W
G
Site 49
T442
A
Q
N
R
S
T
I
T
Y
R
S
W
G
R
S
Site 50
Y443
Q
N
R
S
T
I
T
Y
R
S
W
G
R
S
L
Site 51
S445
R
S
T
I
T
Y
R
S
W
G
R
S
L
K
Y
Site 52
S449
T
Y
R
S
W
G
R
S
L
K
Y
N
P
V
V
Site 53
Y452
S
W
G
R
S
L
K
Y
N
P
V
V
I
D
F
Site 54
T471
I
H
E
V
L
R
H
T
S
L
G
P
L
E
A
Site 55
S472
H
E
V
L
R
H
T
S
L
G
P
L
E
A
K
Site 56
Y490
L
R
R
A
L
D
Q
Y
L
M
E
F
N
A
C
Site 57
T513
G
V
P
I
L
E
G
T
S
C
R
C
Q
C
R
Site 58
S523
R
C
Q
C
R
L
G
S
L
G
A
A
C
E
Q
Site 59
T533
A
A
C
E
Q
T
Q
T
E
G
A
K
A
D
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation