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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRSS1
Full Name:
Trypsin-1
Alias:
EC 3.4.21.4; Protease, serine, 1 (trypsin 1); TRP1; TRY1; TRYP1
Type:
Extracellular region protein
Mass (Da):
26558
Number AA:
247
UniProt ID:
P07477
International Prot ID:
IPI00011694
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005515
GO:0004252
PhosphoSite+
KinaseNET
Biological Process:
GO:0007586
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
N
P
L
L
I
L
T
F
V
A
A
A
L
A
Site 2
S40
N
S
V
P
Y
Q
V
S
L
N
S
G
Y
H
F
Site 3
Y45
Q
V
S
L
N
S
G
Y
H
F
C
G
G
S
L
Site 4
Y65
V
V
S
A
G
H
C
Y
K
S
R
I
Q
V
R
Site 5
S67
S
A
G
H
C
Y
K
S
R
I
Q
V
R
L
G
Site 6
Y99
K
I
I
R
H
P
Q
Y
D
R
K
T
L
N
N
Site 7
S127
N
A
R
V
S
T
I
S
L
P
T
A
P
P
A
Site 8
S142
T
G
T
K
C
L
I
S
G
W
G
N
T
A
S
Site 9
S149
S
G
W
G
N
T
A
S
S
G
A
D
Y
P
D
Site 10
S150
G
W
G
N
T
A
S
S
G
A
D
Y
P
D
E
Site 11
Y154
T
A
S
S
G
A
D
Y
P
D
E
L
Q
C
L
Site 12
Y175
Q
A
K
C
E
A
S
Y
P
G
K
I
T
S
N
Site 13
S195
F
L
E
G
G
K
D
S
C
Q
G
D
S
G
G
Site 14
S215
G
Q
L
Q
G
V
V
S
W
G
D
G
C
A
Q
Site 15
Y229
Q
K
N
K
P
G
V
Y
T
K
V
Y
N
Y
V
Site 16
T230
K
N
K
P
G
V
Y
T
K
V
Y
N
Y
V
K
Site 17
Y233
P
G
V
Y
T
K
V
Y
N
Y
V
K
W
I
K
Site 18
Y235
V
Y
T
K
V
Y
N
Y
V
K
W
I
K
N
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation