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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HEXB
Full Name:
Beta-hexosaminidase subunit beta
Alias:
N-acetyl-beta-glucosaminidase
Type:
Mass (Da):
63093
Number AA:
556
UniProt ID:
P07686
International Prot ID:
IPI00012585
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000323
GO:0001669
GO:0005764
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004553
GO:0004563
PhosphoSite+
KinaseNET
Biological Process:
GO:0000003
GO:0001501
GO:0001573
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S47
A
E
A
A
R
A
P
S
V
S
A
K
P
G
P
Site 2
S49
A
A
R
A
P
S
V
S
A
K
P
G
P
A
L
Site 3
Y78
H
L
A
P
E
N
F
Y
I
S
H
S
P
N
S
Site 4
S80
A
P
E
N
F
Y
I
S
H
S
P
N
S
T
A
Site 5
S82
E
N
F
Y
I
S
H
S
P
N
S
T
A
G
P
Site 6
S85
Y
I
S
H
S
P
N
S
T
A
G
P
S
C
T
Site 7
T86
I
S
H
S
P
N
S
T
A
G
P
S
C
T
L
Site 8
Y101
L
E
E
A
F
R
R
Y
H
G
Y
I
F
G
F
Site 9
T122
P
A
E
F
Q
A
K
T
Q
V
Q
Q
L
L
V
Site 10
S144
C
D
A
F
P
N
I
S
S
D
E
S
Y
T
L
Site 11
S145
D
A
F
P
N
I
S
S
D
E
S
Y
T
L
L
Site 12
S148
P
N
I
S
S
D
E
S
Y
T
L
L
V
K
E
Site 13
Y149
N
I
S
S
D
E
S
Y
T
L
L
V
K
E
P
Site 14
S176
L
R
G
L
E
T
F
S
Q
L
V
Y
Q
D
S
Site 15
Y180
E
T
F
S
Q
L
V
Y
Q
D
S
Y
G
T
F
Site 16
S183
S
Q
L
V
Y
Q
D
S
Y
G
T
F
T
I
N
Site 17
Y184
Q
L
V
Y
Q
D
S
Y
G
T
F
T
I
N
E
Site 18
T188
Q
D
S
Y
G
T
F
T
I
N
E
S
T
I
I
Site 19
T193
T
F
T
I
N
E
S
T
I
I
D
S
P
R
F
Site 20
S197
N
E
S
T
I
I
D
S
P
R
F
S
H
R
G
Site 21
S201
I
I
D
S
P
R
F
S
H
R
G
I
L
I
D
Site 22
T209
H
R
G
I
L
I
D
T
S
R
H
Y
L
P
V
Site 23
S210
R
G
I
L
I
D
T
S
R
H
Y
L
P
V
K
Site 24
Y246
V
D
D
Q
S
F
P
Y
Q
S
I
T
F
P
E
Site 25
S248
D
Q
S
F
P
Y
Q
S
I
T
F
P
E
L
S
Site 26
T250
S
F
P
Y
Q
S
I
T
F
P
E
L
S
N
K
Site 27
S255
S
I
T
F
P
E
L
S
N
K
G
S
Y
S
L
Site 28
S259
P
E
L
S
N
K
G
S
Y
S
L
S
H
V
Y
Site 29
S261
L
S
N
K
G
S
Y
S
L
S
H
V
Y
T
P
Site 30
S263
N
K
G
S
Y
S
L
S
H
V
Y
T
P
N
D
Site 31
T267
Y
S
L
S
H
V
Y
T
P
N
D
V
R
M
V
Site 32
Y277
D
V
R
M
V
I
E
Y
A
R
L
R
G
I
R
Site 33
T291
R
V
L
P
E
F
D
T
P
G
H
T
L
S
W
Site 34
T295
E
F
D
T
P
G
H
T
L
S
W
G
K
G
Q
Site 35
S297
D
T
P
G
H
T
L
S
W
G
K
G
Q
K
D
Site 36
T307
K
G
Q
K
D
L
L
T
P
C
Y
S
R
Q
N
Site 37
Y310
K
D
L
L
T
P
C
Y
S
R
Q
N
K
L
D
Site 38
S311
D
L
L
T
P
C
Y
S
R
Q
N
K
L
D
S
Site 39
S318
S
R
Q
N
K
L
D
S
F
G
P
I
N
P
T
Site 40
T325
S
F
G
P
I
N
P
T
L
N
T
T
Y
S
F
Site 41
T328
P
I
N
P
T
L
N
T
T
Y
S
F
L
T
T
Site 42
T335
T
T
Y
S
F
L
T
T
F
F
K
E
I
S
E
Site 43
S341
T
T
F
F
K
E
I
S
E
V
F
P
D
Q
F
Site 44
S385
T
D
F
K
K
L
E
S
F
Y
I
Q
K
V
L
Site 45
S427
I
V
E
V
W
K
D
S
A
Y
P
E
E
L
S
Site 46
Y429
E
V
W
K
D
S
A
Y
P
E
E
L
S
R
V
Site 47
S434
S
A
Y
P
E
E
L
S
R
V
T
A
S
G
F
Site 48
Y456
W
Y
L
D
L
I
S
Y
G
Q
D
W
R
K
Y
Site 49
Y463
Y
G
Q
D
W
R
K
Y
Y
K
V
E
P
L
D
Site 50
Y464
G
Q
D
W
R
K
Y
Y
K
V
E
P
L
D
F
Site 51
Y492
E
A
C
L
W
G
E
Y
V
D
A
T
N
L
T
Site 52
T499
Y
V
D
A
T
N
L
T
P
R
L
W
P
R
A
Site 53
S507
P
R
L
W
P
R
A
S
A
V
G
E
R
L
W
Site 54
S515
A
V
G
E
R
L
W
S
S
K
D
V
R
D
M
Site 55
S516
V
G
E
R
L
W
S
S
K
D
V
R
D
M
D
Site 56
Y526
V
R
D
M
D
D
A
Y
D
R
L
T
R
H
R
Site 57
Y547
G
I
A
A
Q
P
L
Y
A
G
Y
C
N
H
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation