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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EPRS
Full Name:
Bifunctional aminoacyl-tRNA synthetase
Alias:
Bifunctional aminoacyl-tRNA synthetase; EARS; EC 6.1.1.15; EC 6.1.1.17; GLNS; Glutamate tRNA ligase; Glutamate-tRNA ligase; Glutamyl-prolyl-tRNA synthetase; Glutamyl-tRNA synthetase; PARS; Proline tRNA ligase; Proline-tRNA ligase; Prolyl-tRNA synthetase; QARS; QPRS; SYEP
Type:
Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 6.1.1.15; EC 6.1.1.17; Ligase
Mass (Da):
170591
Number AA:
1512
UniProt ID:
P07814
International Prot ID:
IPI00013452
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003723
GO:0004818
PhosphoSite+
KinaseNET
Biological Process:
GO:0006424
GO:0006433
GO:0006461
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
A
T
L
S
L
T
V
N
S
G
D
P
P
Site 2
S29
E
H
V
K
D
D
V
S
I
S
V
E
E
G
K
Site 3
S31
V
K
D
D
V
S
I
S
V
E
E
G
K
E
N
Site 4
S85
I
D
H
W
L
E
F
S
A
T
K
L
S
S
C
Site 5
T87
H
W
L
E
F
S
A
T
K
L
S
S
C
D
S
Site 6
S90
E
F
S
A
T
K
L
S
S
C
D
S
F
T
S
Site 7
S91
F
S
A
T
K
L
S
S
C
D
S
F
T
S
T
Site 8
S94
T
K
L
S
S
C
D
S
F
T
S
T
I
N
E
Site 9
S97
S
S
C
D
S
F
T
S
T
I
N
E
L
N
H
Site 10
T98
S
C
D
S
F
T
S
T
I
N
E
L
N
H
C
Site 11
S107
N
E
L
N
H
C
L
S
L
R
T
Y
L
V
G
Site 12
S170
V
G
T
K
W
D
V
S
T
T
K
A
R
V
A
Site 13
T199
G
A
E
M
G
K
V
T
V
R
F
P
P
E
A
Site 14
Y209
F
P
P
E
A
S
G
Y
L
H
I
G
H
A
K
Site 15
Y224
A
A
L
L
N
Q
H
Y
Q
V
N
F
K
G
K
Site 16
T239
L
I
M
R
F
D
D
T
N
P
E
K
E
K
E
Site 17
Y279
H
F
E
T
I
M
K
Y
A
E
K
L
I
Q
E
Site 18
Y290
L
I
Q
E
G
K
A
Y
V
D
D
T
P
A
E
Site 19
T294
G
K
A
Y
V
D
D
T
P
A
E
Q
M
K
A
Site 20
S309
E
R
E
Q
R
I
E
S
K
H
R
K
N
P
I
Site 21
S345
L
R
A
K
I
D
M
S
S
N
N
G
C
M
R
Site 22
S346
R
A
K
I
D
M
S
S
N
N
G
C
M
R
D
Site 23
T355
N
G
C
M
R
D
P
T
L
Y
R
C
K
I
Q
Site 24
Y357
C
M
R
D
P
T
L
Y
R
C
K
I
Q
P
H
Site 25
T367
K
I
Q
P
H
P
R
T
G
N
K
Y
N
V
Y
Site 26
Y371
H
P
R
T
G
N
K
Y
N
V
Y
P
T
Y
D
Site 27
Y374
T
G
N
K
Y
N
V
Y
P
T
Y
D
F
A
C
Site 28
Y377
K
Y
N
V
Y
P
T
Y
D
F
A
C
P
I
V
Site 29
T397
V
T
H
A
L
R
T
T
E
Y
H
D
R
D
E
Site 30
Y399
H
A
L
R
T
T
E
Y
H
D
R
D
E
Q
F
Site 31
Y407
H
D
R
D
E
Q
F
Y
W
I
I
E
A
L
G
Site 32
Y419
A
L
G
I
R
K
P
Y
I
W
E
Y
S
R
L
Site 33
Y423
R
K
P
Y
I
W
E
Y
S
R
L
N
L
N
N
Site 34
T431
S
R
L
N
L
N
N
T
V
L
S
K
R
K
L
Site 35
S434
N
L
N
N
T
V
L
S
K
R
K
L
T
W
F
Site 36
T439
V
L
S
K
R
K
L
T
W
F
V
N
E
G
L
Site 37
T457
W
D
D
P
R
F
P
T
V
R
G
V
L
R
R
Site 38
T467
G
V
L
R
R
G
M
T
V
E
G
L
K
Q
F
Site 39
S483
A
A
Q
G
S
S
R
S
V
V
N
M
E
W
D
Site 40
Y507
I
D
P
V
A
P
R
Y
V
A
L
L
K
K
E
Site 41
Y546
V
G
L
K
P
V
W
Y
S
P
K
V
F
I
E
Site 42
S547
G
L
K
P
V
W
Y
S
P
K
V
F
I
E
G
Site 43
T559
I
E
G
A
D
A
E
T
F
S
E
G
E
M
V
Site 44
S561
G
A
D
A
E
T
F
S
E
G
E
M
V
T
F
Site 45
S589
N
A
D
G
K
I
I
S
L
D
A
K
L
N
L
Site 46
Y601
L
N
L
E
N
K
D
Y
K
K
T
T
K
V
T
Site 47
T631
V
T
Y
E
H
L
I
T
K
P
V
L
G
K
D
Site 48
Y644
K
D
E
D
F
K
Q
Y
V
N
K
N
S
K
H
Site 49
Y684
F
F
I
C
D
Q
P
Y
E
P
V
S
P
Y
S
Site 50
S688
D
Q
P
Y
E
P
V
S
P
Y
S
C
K
E
A
Site 51
Y690
P
Y
E
P
V
S
P
Y
S
C
K
E
A
P
C
Site 52
S691
Y
E
P
V
S
P
Y
S
C
K
E
A
P
C
V
Site 53
S713
H
T
K
E
M
P
T
S
G
S
K
E
K
T
K
Site 54
T719
T
S
G
S
K
E
K
T
K
V
E
A
T
K
N
Site 55
T737
A
P
F
K
E
R
P
T
P
S
L
N
N
N
C
Site 56
T745
P
S
L
N
N
N
C
T
T
S
E
D
S
L
V
Site 57
T746
S
L
N
N
N
C
T
T
S
E
D
S
L
V
L
Site 58
S747
L
N
N
N
C
T
T
S
E
D
S
L
V
L
Y
Site 59
S750
N
C
T
T
S
E
D
S
L
V
L
Y
N
R
V
Site 60
Y754
S
E
D
S
L
V
L
Y
N
R
V
A
V
Q
G
Site 61
S813
A
E
I
G
Q
N
I
S
S
N
S
S
A
S
I
Site 62
S814
E
I
G
Q
N
I
S
S
N
S
S
A
S
I
L
Site 63
S816
G
Q
N
I
S
S
N
S
S
A
S
I
L
E
S
Site 64
S817
Q
N
I
S
S
N
S
S
A
S
I
L
E
S
K
Site 65
S819
I
S
S
N
S
S
A
S
I
L
E
S
K
S
L
Site 66
S823
S
S
A
S
I
L
E
S
K
S
L
Y
D
E
V
Site 67
S825
A
S
I
L
E
S
K
S
L
Y
D
E
V
A
A
Site 68
Y827
I
L
E
S
K
S
L
Y
D
E
V
A
A
Q
G
Site 69
S845
R
K
L
K
A
E
K
S
P
K
A
K
I
N
E
Site 70
S859
E
A
V
E
C
L
L
S
L
K
A
Q
Y
K
E
Site 71
Y864
L
L
S
L
K
A
Q
Y
K
E
K
T
G
K
E
Site 72
Y872
K
E
K
T
G
K
E
Y
I
P
G
Q
P
P
L
Site 73
S880
I
P
G
Q
P
P
L
S
Q
S
S
D
S
S
P
Site 74
S882
G
Q
P
P
L
S
Q
S
S
D
S
S
P
T
R
Site 75
S883
Q
P
P
L
S
Q
S
S
D
S
S
P
T
R
N
Site 76
S885
P
L
S
Q
S
S
D
S
S
P
T
R
N
S
E
Site 77
S886
L
S
Q
S
S
D
S
S
P
T
R
N
S
E
P
Site 78
T888
Q
S
S
D
S
S
P
T
R
N
S
E
P
A
G
Site 79
S891
D
S
S
P
T
R
N
S
E
P
A
G
L
E
T
Site 80
T898
S
E
P
A
G
L
E
T
P
E
A
K
V
L
F
Site 81
S910
V
L
F
D
K
V
A
S
Q
G
E
V
V
R
K
Site 82
S944
Q
L
K
A
Q
Y
K
S
L
I
G
V
E
Y
K
Site 83
Y950
K
S
L
I
G
V
E
Y
K
P
V
S
A
T
G
Site 84
S954
G
V
E
Y
K
P
V
S
A
T
G
A
E
D
K
Site 85
S972
K
K
E
K
E
N
K
S
E
K
Q
N
K
P
Q
Site 86
S990
D
G
Q
R
K
D
P
S
K
N
Q
G
G
G
L
Site 87
S998
K
N
Q
G
G
G
L
S
S
S
G
A
G
E
G
Site 88
S999
N
Q
G
G
G
L
S
S
S
G
A
G
E
G
Q
Site 89
S1000
Q
G
G
G
L
S
S
S
G
A
G
E
G
Q
G
Site 90
T1012
G
Q
G
P
K
K
Q
T
R
L
G
L
E
A
K
Site 91
Y1028
E
E
N
L
A
D
W
Y
S
Q
V
I
T
K
S
Site 92
S1029
E
N
L
A
D
W
Y
S
Q
V
I
T
K
S
E
Site 93
Y1040
T
K
S
E
M
I
E
Y
H
D
I
S
G
C
Y
Site 94
S1083
C
Y
F
P
M
F
V
S
Q
S
A
L
E
K
E
Site 95
T1092
S
A
L
E
K
E
K
T
H
V
A
D
F
A
P
Site 96
S1107
E
V
A
W
V
T
R
S
G
K
T
E
L
A
E
Site 97
T1121
E
P
I
A
I
R
P
T
S
E
T
V
M
Y
P
Site 98
T1124
A
I
R
P
T
S
E
T
V
M
Y
P
A
Y
A
Site 99
Y1127
P
T
S
E
T
V
M
Y
P
A
Y
A
K
W
V
Site 100
Y1130
E
T
V
M
Y
P
A
Y
A
K
W
V
Q
S
H
Site 101
T1178
E
G
H
S
A
F
A
T
M
E
E
A
A
E
E
Site 102
T1211
P
V
V
K
G
R
K
T
E
K
E
K
F
A
G
Site 103
Y1221
E
K
F
A
G
G
D
Y
T
T
T
I
E
A
F
Site 104
Y1269
P
G
E
K
Q
F
A
Y
Q
N
S
W
G
L
T
Site 105
S1316
C
G
I
T
N
A
L
S
E
E
D
K
E
A
L
Site 106
Y1330
L
I
A
K
C
N
D
Y
R
R
R
L
L
S
V
Site 107
S1336
D
Y
R
R
R
L
L
S
V
N
I
R
V
R
A
Site 108
Y1349
R
A
D
L
R
D
N
Y
S
P
G
W
K
F
N
Site 109
S1350
A
D
L
R
D
N
Y
S
P
G
W
K
F
N
H
Site 110
S1376
V
G
P
R
D
M
K
S
C
Q
F
V
A
V
R
Site 111
T1391
R
D
T
G
E
K
L
T
V
A
E
N
E
A
E
Site 112
S1417
V
T
L
F
T
R
A
S
E
D
L
K
T
H
M
Site 113
T1422
R
A
S
E
D
L
K
T
H
M
V
V
A
N
T
Site 114
S1439
D
F
Q
K
I
L
D
S
G
K
I
V
Q
I
P
Site 115
S1473
D
L
E
P
G
A
P
S
M
G
A
K
S
L
C
Site 116
Y1504
C
G
K
N
P
A
K
Y
Y
T
L
F
G
R
S
Site 117
Y1505
G
K
N
P
A
K
Y
Y
T
L
F
G
R
S
Y
Site 118
T1506
K
N
P
A
K
Y
Y
T
L
F
G
R
S
Y
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation