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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CTSB
Full Name:
Cathepsin B
Alias:
Amyloid precursor secretase; APP secretase; APPS; CATB; Cathepsin B1; CPSB; Cysteine protease; EC 3.4.22.1; Preprocathepsin B
Type:
Autophagy; EC 3.4.22.1; Protease
Mass (Da):
37822
Number AA:
339
UniProt ID:
P07858
International Prot ID:
IPI00295741
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005764
GO:0042470
Uniprot
OncoNet
Molecular Function:
GO:0004197
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
GO:0042981
GO:0050790
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
L
V
L
A
N
A
R
S
R
P
S
F
H
P
L
Site 2
S22
A
N
A
R
S
R
P
S
F
H
P
L
S
D
E
Site 3
S27
R
P
S
F
H
P
L
S
D
E
L
V
N
Y
V
Site 4
Y33
L
S
D
E
L
V
N
Y
V
N
K
R
N
T
T
Site 5
Y54
F
Y
N
V
D
M
S
Y
L
K
R
L
C
G
T
Site 6
T61
Y
L
K
R
L
C
G
T
F
L
G
G
P
K
P
Site 7
S83
E
D
L
K
L
P
A
S
F
D
A
R
E
Q
W
Site 8
T125
S
D
R
I
C
I
H
T
N
A
H
V
S
V
E
Site 9
S130
I
H
T
N
A
H
V
S
V
E
V
S
A
E
D
Site 10
Y154
G
D
G
C
N
G
G
Y
P
A
E
A
W
N
F
Site 11
S169
W
T
R
K
G
L
V
S
G
G
L
Y
E
S
H
Site 12
S175
V
S
G
G
L
Y
E
S
H
V
G
C
R
P
Y
Site 13
Y182
S
H
V
G
C
R
P
Y
S
I
P
P
C
E
H
Site 14
T199
N
G
S
R
P
P
C
T
G
E
G
D
T
P
K
Site 15
T204
P
C
T
G
E
G
D
T
P
K
C
S
K
I
C
Site 16
S208
E
G
D
T
P
K
C
S
K
I
C
E
P
G
Y
Site 17
Y215
S
K
I
C
E
P
G
Y
S
P
T
Y
K
Q
D
Site 18
S216
K
I
C
E
P
G
Y
S
P
T
Y
K
Q
D
K
Site 19
Y219
E
P
G
Y
S
P
T
Y
K
Q
D
K
H
Y
G
Site 20
Y225
T
Y
K
Q
D
K
H
Y
G
Y
N
S
Y
S
V
Site 21
Y227
K
Q
D
K
H
Y
G
Y
N
S
Y
S
V
S
N
Site 22
S229
D
K
H
Y
G
Y
N
S
Y
S
V
S
N
S
E
Site 23
S231
H
Y
G
Y
N
S
Y
S
V
S
N
S
E
K
D
Site 24
S233
G
Y
N
S
Y
S
V
S
N
S
E
K
D
I
M
Site 25
S235
N
S
Y
S
V
S
N
S
E
K
D
I
M
A
E
Site 26
Y262
V
Y
S
D
F
L
L
Y
K
S
G
V
Y
Q
H
Site 27
S264
S
D
F
L
L
Y
K
S
G
V
Y
Q
H
V
T
Site 28
Y267
L
L
Y
K
S
G
V
Y
Q
H
V
T
G
E
M
Site 29
T271
S
G
V
Y
Q
H
V
T
G
E
M
M
G
G
H
Site 30
Y293
G
V
E
N
G
T
P
Y
W
L
V
A
N
S
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation