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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
THBS1
Full Name:
Thrombospondin-1
Alias:
THBS; THBS-1; Thrombospondin 1; Thrombospondin-1; Thrombospondin-1 p180; Thrombospondin-1p180; TSP; TSP1; TSP-1
Type:
Inhibitor protein
Mass (Da):
129383
Number AA:
1170
UniProt ID:
P07996
International Prot ID:
IPI00296099
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0009897
GO:0031012
GO:0005577
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0070052
GO:0043499
PhosphoSite+
KinaseNET
Biological Process:
GO:0000187
GO:0006916
GO:0006915
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
G
T
N
R
I
P
E
S
G
G
D
N
S
V
F
Site 2
S29
P
E
S
G
G
D
N
S
V
F
D
I
F
E
L
Site 3
S44
T
G
A
A
R
K
G
S
G
R
R
L
V
K
G
Site 4
S55
L
V
K
G
P
D
P
S
S
P
A
F
R
I
E
Site 5
S56
V
K
G
P
D
P
S
S
P
A
F
R
I
E
D
Site 6
S93
K
G
F
L
L
L
A
S
L
R
Q
M
K
K
T
Site 7
T100
S
L
R
Q
M
K
K
T
R
G
T
L
L
A
L
Site 8
T103
Q
M
K
K
T
R
G
T
L
L
A
L
E
R
K
Site 9
S113
A
L
E
R
K
D
H
S
G
Q
V
F
S
V
V
Site 10
S118
D
H
S
G
Q
V
F
S
V
V
S
N
G
K
A
Site 11
S131
K
A
G
T
L
D
L
S
L
T
V
Q
G
K
Q
Site 12
T133
G
T
L
D
L
S
L
T
V
Q
G
K
Q
H
V
Site 13
T157
T
G
Q
W
K
S
I
T
L
F
V
Q
E
D
R
Site 14
Y168
Q
E
D
R
A
Q
L
Y
I
D
C
E
K
M
E
Site 15
T221
N
V
R
F
V
F
G
T
T
P
E
D
I
L
R
Site 16
T222
V
R
F
V
F
G
T
T
P
E
D
I
L
R
N
Site 17
S234
L
R
N
K
G
C
S
S
S
T
S
V
L
L
T
Site 18
S235
R
N
K
G
C
S
S
S
T
S
V
L
L
T
L
Site 19
S237
K
G
C
S
S
S
T
S
V
L
L
T
L
D
N
Site 20
S251
N
N
V
V
N
G
S
S
P
A
I
R
T
N
Y
Site 21
Y258
S
P
A
I
R
T
N
Y
I
G
H
K
T
K
D
Site 22
T292
R
G
L
R
T
I
V
T
T
L
Q
D
S
I
R
Site 23
T293
G
L
R
T
I
V
T
T
L
Q
D
S
I
R
K
Site 24
S297
I
V
T
T
L
Q
D
S
I
R
K
V
T
E
E
Site 25
T302
Q
D
S
I
R
K
V
T
E
E
N
K
E
L
A
Site 26
Y319
L
R
R
P
P
L
C
Y
H
N
G
V
Q
Y
R
Site 27
S377
P
R
C
W
P
S
D
S
A
D
D
G
W
S
P
Site 28
S383
D
S
A
D
D
G
W
S
P
W
S
E
W
T
S
Site 29
S405
G
I
Q
Q
R
G
R
S
C
D
S
L
N
N
R
Site 30
S408
Q
R
G
R
S
C
D
S
L
N
N
R
C
E
G
Site 31
S416
L
N
N
R
C
E
G
S
S
V
Q
T
R
T
C
Site 32
S464
T
R
I
R
L
C
N
S
P
S
P
Q
M
N
G
Site 33
S466
I
R
L
C
N
S
P
S
P
Q
M
N
G
K
P
Site 34
T481
C
E
G
E
A
R
E
T
K
A
C
K
K
D
A
Site 35
T523
S
R
L
C
N
N
P
T
P
Q
F
G
G
K
D
Site 36
T563
C
F
A
G
V
K
C
T
S
Y
P
D
G
S
W
Site 37
S564
F
A
G
V
K
C
T
S
Y
P
D
G
S
W
K
Site 38
Y565
A
G
V
K
C
T
S
Y
P
D
G
S
W
K
C
Site 39
S569
C
T
S
Y
P
D
G
S
W
K
C
G
A
C
P
Site 40
Y579
C
G
A
C
P
P
G
Y
S
G
N
G
I
Q
C
Site 41
T587
S
G
N
G
I
Q
C
T
D
V
D
E
C
K
E
Site 42
Y615
C
E
N
T
D
P
G
Y
N
C
L
P
C
P
P
Site 43
T625
L
P
C
P
P
R
F
T
G
S
Q
P
F
G
Q
Site 44
S627
C
P
P
R
F
T
G
S
Q
P
F
G
Q
G
V
Site 45
Y665
N
K
N
A
K
C
N
Y
L
G
H
Y
S
D
P
Site 46
Y669
K
C
N
Y
L
G
H
Y
S
D
P
M
Y
R
C
Site 47
Y674
G
H
Y
S
D
P
M
Y
R
C
E
C
K
P
G
Site 48
Y682
R
C
E
C
K
P
G
Y
A
G
N
G
I
I
C
Site 49
S724
N
C
P
N
L
P
N
S
G
Q
E
D
Y
D
K
Site 50
Y729
P
N
S
G
Q
E
D
Y
D
K
D
G
I
G
D
Site 51
Y765
Y
N
P
A
Q
Y
D
Y
D
R
D
D
V
G
D
Site 52
T788
H
N
P
D
Q
A
D
T
D
N
N
G
E
G
D
Site 53
Y815
N
E
R
D
N
C
Q
Y
V
Y
N
V
D
Q
R
Site 54
Y817
R
D
N
C
Q
Y
V
Y
N
V
D
Q
R
D
T
Site 55
S847
H
N
P
D
Q
L
D
S
D
S
D
R
I
G
D
Site 56
S849
P
D
Q
L
D
S
D
S
D
R
I
G
D
T
C
Site 57
Y876
N
N
L
D
N
C
P
Y
V
P
N
A
N
Q
A
Site 58
S921
P
N
P
D
Q
K
D
S
D
G
D
G
R
G
D
Site 59
S938
K
D
D
F
D
H
D
S
V
P
D
I
D
D
I
Site 60
S971
P
L
D
P
K
G
T
S
Q
N
D
P
N
W
V
Site 61
T989
Q
G
K
E
L
V
Q
T
V
N
C
D
P
G
L
Site 62
T1011
N
A
V
D
F
S
G
T
F
F
I
N
T
E
R
Site 63
T1016
S
G
T
F
F
I
N
T
E
R
D
D
D
Y
A
Site 64
Y1022
N
T
E
R
D
D
D
Y
A
G
F
V
F
G
Y
Site 65
Y1029
Y
A
G
F
V
F
G
Y
Q
S
S
S
R
F
Y
Site 66
Y1036
Y
Q
S
S
S
R
F
Y
V
V
M
W
K
Q
V
Site 67
T1050
V
T
Q
S
Y
W
D
T
N
P
T
R
A
Q
G
Site 68
Y1058
N
P
T
R
A
Q
G
Y
S
G
L
S
V
K
V
Site 69
S1059
P
T
R
A
Q
G
Y
S
G
L
S
V
K
V
V
Site 70
S1062
A
Q
G
Y
S
G
L
S
V
K
V
V
N
S
T
Site 71
S1068
L
S
V
K
V
V
N
S
T
T
G
P
G
E
H
Site 72
T1069
S
V
K
V
V
N
S
T
T
G
P
G
E
H
L
Site 73
T1086
A
L
W
H
T
G
N
T
P
G
Q
V
R
T
L
Site 74
Y1108
G
W
K
D
F
T
A
Y
R
W
R
L
S
H
R
Site 75
S1113
T
A
Y
R
W
R
L
S
H
R
P
K
T
G
F
Site 76
T1118
R
L
S
H
R
P
K
T
G
F
I
R
V
V
M
Site 77
Y1126
G
F
I
R
V
V
M
Y
E
G
K
K
I
M
A
Site 78
S1135
G
K
K
I
M
A
D
S
G
P
I
Y
D
K
T
Site 79
Y1139
M
A
D
S
G
P
I
Y
D
K
T
Y
A
G
G
Site 80
T1142
S
G
P
I
Y
D
K
T
Y
A
G
G
R
L
G
Site 81
Y1143
G
P
I
Y
D
K
T
Y
A
G
G
R
L
G
L
Site 82
Y1165
V
F
F
S
D
L
K
Y
E
C
R
D
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation