PhosphoNET

           
Protein Info 
   
Short Name:  GJB1
Full Name:  Gap junction beta-1 protein
Alias:  Charcot-Marie-Tooth neuropathy, X-linked; CMTX; CMTX1; Connexin 32; Connexin-32; CX32; CXB1; Gap junction 28 kDa liver protein; GAP junction 28 kDa liver protein; Gap junction protein, beta 1, 32kDa
Type:  Cytoskeletal protein
Mass (Da):  32025
Number AA:  283
UniProt ID:  P08034
International Prot ID:  IPI00027190
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005922  GO:0005789  GO:0016021 Uniprot OncoNet
Molecular Function:  GO:0005243     PhosphoSite+ KinaseNET
Biological Process:  GO:0007267  GO:0007399  GO:0006810 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S11TGLYTLLSGVNRHST
Site 2S17LSGVNRHSTAIGRVW
Site 3T18SGVNRHSTAIGRVWL
Site 4T55KSSFICNTLQPGCNS
Site 5Y171RLVKCDVYPCPNTVD
Site 6T185DCFVSRPTEKTVFTV
Site 7S225ARRAQRRSNPPSRKG
Site 8S229QRRSNPPSRKGSGFG
Site 9S233NPPSRKGSGFGHRLS
Site 10S240SGFGHRLSPEYKQNE
Site 11Y243GHRLSPEYKQNEINK
Site 12S253NEINKLLSEQDGSLK
Site 13S258LLSEQDGSLKDILRR
Site 14S266LKDILRRSPGTGAGL
Site 15T269ILRRSPGTGAGLAEK
Site 16S277GAGLAEKSDRCSAC_
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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