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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HSPA1A
Full Name:
Heat shock 70 kDa protein 1A/1B
Alias:
Heat shock 70 kDa protein 1; Heat shock 70kDa protein 1A; HS71B; HSP70.1; HSP70-1; HSP70-1/HSP70-2; HSP71; HSPA1; HSPA1B
Type:
Chaperone protein
Mass (Da):
70052
Number AA:
641
UniProt ID:
P08107
International Prot ID:
IPI00304925
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0005739
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0051082
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0006402
GO:0006986
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y15
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Site 2
S16
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
Site 3
T38
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
Site 4
S40
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
Site 5
Y41
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
E
Site 6
T47
S
Y
V
A
F
T
D
T
E
R
L
I
G
D
A
Site 7
T66
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
Site 8
S106
D
K
P
K
V
Q
V
S
Y
K
G
E
T
K
A
Site 9
Y107
K
P
K
V
Q
V
S
Y
K
G
E
T
K
A
F
Site 10
Y115
K
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
Site 11
S121
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
Site 12
T125
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
Site 13
Y149
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
Site 14
S153
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
Site 15
T158
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
Site 16
T222
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
Site 17
T226
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
Site 18
S254
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
Site 19
T265
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
Site 20
T273
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
Site 21
S275
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
Site 22
S276
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
Site 23
S277
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
Site 24
Y294
L
F
E
G
I
D
F
Y
T
S
I
T
R
A
R
Site 25
S296
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
E
Site 26
T298
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
Site 27
S307
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
Site 28
S312
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
Site 29
T313
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
Site 30
S362
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
Site 31
Y371
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
Site 32
S385
A
I
L
M
G
D
K
S
E
N
V
Q
D
L
L
Site 33
S418
T
A
L
I
K
R
N
S
T
I
P
T
K
Q
T
Site 34
T419
A
L
I
K
R
N
S
T
I
P
T
K
Q
T
Q
Site 35
Y431
Q
T
Q
I
F
T
T
Y
S
D
N
Q
P
G
V
Site 36
T450
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
Site 37
T477
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
Site 38
S494
N
V
T
A
T
D
K
S
T
G
K
A
N
K
I
Site 39
T502
T
G
K
A
N
K
I
T
I
T
N
D
K
G
R
Site 40
S511
T
N
D
K
G
R
L
S
K
E
E
I
E
R
M
Site 41
Y525
M
V
Q
E
A
E
K
Y
K
A
E
D
E
V
Q
Site 42
S537
E
V
Q
R
E
R
V
S
A
K
N
A
L
E
S
Site 43
S551
S
Y
A
F
N
M
K
S
A
V
E
D
E
G
L
Site 44
S563
E
G
L
K
G
K
I
S
E
A
D
K
K
K
V
Site 45
T585
I
S
W
L
D
A
N
T
L
A
E
K
D
E
F
Site 46
Y611
N
P
I
I
S
G
L
Y
Q
G
A
G
G
P
G
Site 47
S631
A
Q
G
P
K
G
G
S
G
S
G
P
T
I
E
Site 48
S633
G
P
K
G
G
S
G
S
G
P
T
I
E
E
V
Site 49
T636
G
G
S
G
S
G
P
T
I
E
E
V
D
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation