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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ANXA6
Full Name:
Annexin A6
Alias:
67 kDa calelectrin; Annexin VI; ANX6; Calphobindin-II; Chromobindin 20; CPB-II; Lipocortin VI; P68; P70; Protein III
Type:
Protein type:Â Calcium-binding protein, Lipid binding protein
Mass (Da):
75873
Number AA:
673
UniProt ID:
P08133
International Prot ID:
IPI00221226
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0042470
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005544
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
Q
G
A
K
Y
R
G
S
I
H
D
F
P
G
F
Site 2
Y30
N
Q
D
A
E
A
L
Y
T
A
M
K
G
F
G
Site 3
T31
Q
D
A
E
A
L
Y
T
A
M
K
G
F
G
S
Site 4
S38
T
A
M
K
G
F
G
S
D
K
E
A
I
L
D
Site 5
T48
E
A
I
L
D
I
I
T
S
R
S
N
R
Q
R
Site 6
S49
A
I
L
D
I
I
T
S
R
S
N
R
Q
R
Q
Site 7
S51
L
D
I
I
T
S
R
S
N
R
Q
R
Q
E
V
Site 8
S61
Q
R
Q
E
V
C
Q
S
Y
K
S
L
Y
G
K
Site 9
Y62
R
Q
E
V
C
Q
S
Y
K
S
L
Y
G
K
D
Site 10
S64
E
V
C
Q
S
Y
K
S
L
Y
G
K
D
L
I
Site 11
Y76
D
L
I
A
D
L
K
Y
E
L
T
G
K
F
E
Site 12
Y95
G
L
M
R
P
P
A
Y
C
D
A
K
E
I
K
Site 13
S106
K
E
I
K
D
A
I
S
G
I
G
T
D
E
K
Site 14
T110
D
A
I
S
G
I
G
T
D
E
K
C
L
I
E
Site 15
Y138
V
A
A
Y
K
D
A
Y
E
R
D
L
E
A
D
Site 16
T150
E
A
D
I
I
G
D
T
S
G
H
F
Q
K
M
Site 17
S173
R
E
E
D
D
V
V
S
E
D
L
V
Q
Q
D
Site 18
Y185
Q
Q
D
V
Q
D
L
Y
E
A
G
E
L
K
W
Site 19
Y201
T
D
E
A
Q
F
I
Y
I
L
G
N
R
S
K
Site 20
Y218
L
R
L
V
F
D
E
Y
L
K
T
T
G
K
P
Site 21
T221
V
F
D
E
Y
L
K
T
T
G
K
P
I
E
A
Site 22
S229
T
G
K
P
I
E
A
S
I
R
G
E
L
S
G
Site 23
S235
A
S
I
R
G
E
L
S
G
D
F
E
K
L
M
Site 24
T252
V
V
K
C
I
R
S
T
P
E
Y
F
A
E
R
Site 25
Y255
C
I
R
S
T
P
E
Y
F
A
E
R
L
F
K
Site 26
T269
K
A
M
K
G
L
G
T
R
D
N
T
L
I
R
Site 27
T295
D
I
R
E
I
F
R
T
K
Y
E
K
S
L
Y
Site 28
Y297
R
E
I
F
R
T
K
Y
E
K
S
L
Y
S
M
Site 29
S300
F
R
T
K
Y
E
K
S
L
Y
S
M
I
K
N
Site 30
Y302
R
R
E
F
I
E
K
Y
D
K
S
L
H
Q
A
Site 31
S303
K
Y
E
K
S
L
Y
S
M
I
K
N
D
T
S
Site 32
S310
S
M
I
K
N
D
T
S
G
E
Y
K
K
T
L
Site 33
Y313
K
N
D
T
S
G
E
Y
K
K
T
L
L
K
L
Site 34
T316
T
S
G
E
Y
K
K
T
L
L
K
L
S
G
G
Site 35
Y340
P
E
A
A
Q
V
A
Y
Q
M
W
E
L
S
A
Site 36
T356
A
R
V
E
L
K
G
T
V
R
P
A
N
D
F
Site 37
T391
D
T
I
I
D
I
I
T
H
R
S
N
V
Q
R
Site 38
T404
Q
R
Q
Q
I
R
Q
T
F
K
S
H
F
G
R
Site 39
T415
H
F
G
R
D
L
M
T
D
L
K
S
E
I
S
Site 40
S419
D
L
M
T
D
L
K
S
E
I
S
G
D
L
A
Site 41
Y439
L
M
M
P
P
A
H
Y
D
A
K
Q
L
K
K
Site 42
T453
K
A
M
E
G
A
G
T
D
E
K
A
L
I
E
Site 43
T464
A
L
I
E
I
L
A
T
R
T
N
A
E
I
R
Site 44
Y481
N
E
A
Y
K
E
D
Y
H
K
S
L
E
D
A
Site 45
S484
Y
K
E
D
Y
H
K
S
L
E
D
A
L
S
S
Site 46
S490
K
S
L
E
D
A
L
S
S
D
T
S
G
H
F
Site 47
S491
S
L
E
D
A
L
S
S
D
T
S
G
H
F
R
Site 48
S494
D
A
L
S
S
D
T
S
G
H
F
R
R
I
L
Site 49
S503
H
F
R
R
I
L
I
S
L
A
T
G
H
R
E
Site 50
T535
E
I
L
E
I
A
D
T
P
S
G
D
K
T
S
Site 51
S537
L
E
I
A
D
T
P
S
G
D
K
T
S
L
E
Site 52
T541
D
T
P
S
G
D
K
T
S
L
E
T
R
F
M
Site 53
S542
T
P
S
G
D
K
T
S
L
E
T
R
F
M
T
Site 54
T549
S
L
E
T
R
F
M
T
I
L
C
T
R
S
Y
Site 55
Y556
T
I
L
C
T
R
S
Y
P
H
L
R
R
V
F
Site 56
Y572
E
F
I
K
M
T
N
Y
D
V
E
H
T
I
K
Site 57
S583
H
T
I
K
K
E
M
S
G
D
V
R
D
A
F
Site 58
Y609
L
F
F
A
D
K
L
Y
K
S
M
K
G
A
G
Site 59
S611
F
A
D
K
L
Y
K
S
M
K
G
A
G
T
D
Site 60
T617
K
S
M
K
G
A
G
T
D
E
K
T
L
T
R
Site 61
T621
G
A
G
T
D
E
K
T
L
T
R
I
M
V
S
Site 62
T623
G
T
D
E
K
T
L
T
R
I
M
V
S
R
S
Site 63
S628
T
L
T
R
I
M
V
S
R
S
E
I
D
L
L
Site 64
Y645
R
R
E
F
I
E
K
Y
D
K
S
L
H
Q
A
Site 65
S648
F
I
E
K
Y
D
K
S
L
H
Q
A
I
E
G
Site 66
S658
Q
A
I
E
G
D
T
S
G
D
F
L
K
A
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation