KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ABCB1
Full Name:
Multidrug resistance protein 1
Alias:
ABC20; ATP-binding cassette sub-family B member 1; ATP-binding cassette, sub-family B (MDR/TAP) member 1; CD243; CD243 antigen; CLCS; GP170; MDR1; MDR3; P-glycoprotein 1; P-gp; PGY1
Type:
Membrane protein, integral; Hydrolase; Adhesion; EC 3.6.3.44; Transporter
Mass (Da):
141479
Number AA:
1280
UniProt ID:
P08183
International Prot ID:
IPI00027481
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0009986
GO:0005925
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0008559
PhosphoSite+
KinaseNET
Biological Process:
GO:0042493
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
F
F
K
L
N
N
K
S
E
K
D
K
K
E
K
Site 2
T33
D
K
K
E
K
K
P
T
V
S
V
F
S
M
F
Site 3
S35
K
E
K
K
P
T
V
S
V
F
S
M
F
R
Y
Site 4
Y42
S
V
F
S
M
F
R
Y
S
N
W
L
D
K
L
Site 5
S90
G
N
L
E
D
L
M
S
N
I
T
N
R
S
D
Site 6
T93
E
D
L
M
S
N
I
T
N
R
S
D
I
N
D
Site 7
Y114
L
E
E
D
M
T
R
Y
A
Y
Y
Y
S
G
I
Site 8
Y116
E
D
M
T
R
Y
A
Y
Y
Y
S
G
I
G
A
Site 9
Y117
D
M
T
R
Y
A
Y
Y
Y
S
G
I
G
A
G
Site 10
T173
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
Site 11
T176
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
Site 12
S180
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
Site 13
T263
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
Site 14
Y277
Q
K
K
E
L
E
R
Y
N
K
N
L
E
E
A
Site 15
S374
K
I
I
D
N
K
P
S
I
D
S
Y
S
K
S
Site 16
S377
D
N
K
P
S
I
D
S
Y
S
K
S
G
H
K
Site 17
Y378
N
K
P
S
I
D
S
Y
S
K
S
G
H
K
P
Site 18
S379
K
P
S
I
D
S
Y
S
K
S
G
H
K
P
D
Site 19
S381
S
I
D
S
Y
S
K
S
G
H
K
P
D
N
I
Site 20
S400
E
F
R
N
V
H
F
S
Y
P
S
R
K
E
V
Site 21
Y401
F
R
N
V
H
F
S
Y
P
S
R
K
E
V
K
Site 22
S434
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
Site 23
T436
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Site 24
Y444
V
Q
L
M
Q
R
L
Y
D
P
T
E
G
M
V
Site 25
T447
M
Q
R
L
Y
D
P
T
E
G
M
V
S
V
D
Site 26
S452
D
P
T
E
G
M
V
S
V
D
G
Q
D
I
R
Site 27
T460
V
D
G
Q
D
I
R
T
I
N
V
R
F
L
R
Site 28
Y490
T
I
A
E
N
I
R
Y
G
R
E
N
V
T
M
Site 29
T496
R
Y
G
R
E
N
V
T
M
D
E
I
E
K
A
Site 30
T522
K
L
P
H
K
F
D
T
L
V
G
E
R
G
A
Site 31
S532
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
Site 32
T563
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
Site 33
T582
K
A
R
K
G
R
T
T
I
V
I
A
H
R
L
Site 34
S644
L
E
N
A
A
D
E
S
K
S
E
I
D
A
L
Site 35
S646
N
A
A
D
E
S
K
S
E
I
D
A
L
E
M
Site 36
S654
E
I
D
A
L
E
M
S
S
N
D
S
R
S
S
Site 37
S655
I
D
A
L
E
M
S
S
N
D
S
R
S
S
L
Site 38
S658
L
E
M
S
S
N
D
S
R
S
S
L
I
R
K
Site 39
S660
M
S
S
N
D
S
R
S
S
L
I
R
K
R
S
Site 40
S661
S
S
N
D
S
R
S
S
L
I
R
K
R
S
T
Site 41
S667
S
S
L
I
R
K
R
S
T
R
R
S
V
R
G
Site 42
T668
S
L
I
R
K
R
S
T
R
R
S
V
R
G
S
Site 43
S671
R
K
R
S
T
R
R
S
V
R
G
S
Q
A
Q
Site 44
S675
T
R
R
S
V
R
G
S
Q
A
Q
D
R
K
L
Site 45
S683
Q
A
Q
D
R
K
L
S
T
K
E
A
L
D
E
Site 46
S691
T
K
E
A
L
D
E
S
I
P
P
V
S
F
W
Site 47
S696
D
E
S
I
P
P
V
S
F
W
R
I
M
K
L
Site 48
T747
T
R
I
D
D
P
E
T
K
R
Q
N
S
N
L
Site 49
S752
P
E
T
K
R
Q
N
S
N
L
F
S
L
L
F
Site 50
T785
G
K
A
G
E
I
L
T
K
R
L
R
Y
M
V
Site 51
S795
L
R
Y
M
V
F
R
S
M
L
R
Q
D
V
S
Site 52
S802
S
M
L
R
Q
D
V
S
W
F
D
D
P
K
N
Site 53
S893
D
K
K
E
L
E
G
S
G
K
I
A
T
E
A
Site 54
T906
E
A
I
E
N
F
R
T
V
V
S
L
T
Q
E
Site 55
S931
L
Q
V
P
Y
R
N
S
L
R
K
A
H
I
F
Site 56
Y998
V
S
S
F
A
P
D
Y
A
K
A
K
I
S
A
Site 57
T1015
I
I
M
I
I
E
K
T
P
L
I
D
S
Y
S
Site 58
S1020
E
K
T
P
L
I
D
S
Y
S
T
E
G
L
M
Site 59
Y1021
K
T
P
L
I
D
S
Y
S
T
E
G
L
M
P
Site 60
S1022
T
P
L
I
D
S
Y
S
T
E
G
L
M
P
N
Site 61
T1023
P
L
I
D
S
Y
S
T
E
G
L
M
P
N
T
Site 62
T1030
T
E
G
L
M
P
N
T
L
E
G
N
V
T
F
Site 63
Y1044
F
G
E
V
V
F
N
Y
P
T
R
P
D
I
P
Site 64
T1078
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
Site 65
Y1087
V
Q
L
L
E
R
F
Y
D
P
L
A
G
K
V
Site 66
Y1133
S
I
A
E
N
I
A
Y
G
D
N
S
R
V
V
Site 67
S1137
N
I
A
Y
G
D
N
S
R
V
V
S
Q
E
E
Site 68
S1141
G
D
N
S
R
V
V
S
Q
E
E
I
V
R
A
Site 69
S1160
N
I
H
A
F
I
E
S
L
P
N
K
Y
S
T
Site 70
S1166
E
S
L
P
N
K
Y
S
T
K
V
G
D
K
G
Site 71
T1174
T
K
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Site 72
S1177
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
Site 73
T1208
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
Site 74
S1210
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation