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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GUSB
Full Name:
Beta-glucuronidase
Alias:
Beta-G1; BGLR; EC 3.2.1.31; glucuronidase, beta
Type:
Glycan Metabolism - glycosaminoglycan degradation; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - starch and sucrose; Xenobiotic Metabolism - drug metabolism - other enzymes; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 3.2.1.31; Hydrolase
Mass (Da):
74732
Number AA:
651
UniProt ID:
P08236
International Prot ID:
IPI00027745
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005764
Uniprot
OncoNet
Molecular Function:
GO:0004566
GO:0043169
PhosphoSite+
KinaseNET
Biological Process:
GO:0006027
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y29
G
L
Q
G
G
M
L
Y
P
Q
E
S
P
S
R
Site 2
S33
G
M
L
Y
P
Q
E
S
P
S
R
E
C
K
E
Site 3
S35
L
Y
P
Q
E
S
P
S
R
E
C
K
E
L
D
Site 4
S46
K
E
L
D
G
L
W
S
F
R
A
D
F
S
D
Site 5
S52
W
S
F
R
A
D
F
S
D
N
R
R
R
G
F
Site 6
Y64
R
G
F
E
E
Q
W
Y
R
R
P
L
W
E
S
Site 7
S71
Y
R
R
P
L
W
E
S
G
P
T
V
D
M
P
Site 8
T74
P
L
W
E
S
G
P
T
V
D
M
P
V
P
S
Site 9
S82
V
D
M
P
V
P
S
S
F
N
D
I
S
Q
D
Site 10
S87
P
S
S
F
N
D
I
S
Q
D
W
R
L
R
H
Site 11
T112
V
I
L
P
E
R
W
T
Q
D
L
R
T
R
V
Site 12
T117
R
W
T
Q
D
L
R
T
R
V
V
L
R
I
G
Site 13
T139
V
W
V
N
G
V
D
T
L
E
H
E
G
G
Y
Site 14
T180
N
N
T
L
T
P
T
T
L
P
P
G
T
I
Q
Site 15
Y188
L
P
P
G
T
I
Q
Y
L
T
D
T
S
K
Y
Site 16
T190
P
G
T
I
Q
Y
L
T
D
T
S
K
Y
P
K
Site 17
T192
T
I
Q
Y
L
T
D
T
S
K
Y
P
K
G
Y
Site 18
Y195
Y
L
T
D
T
S
K
Y
P
K
G
Y
F
V
Q
Site 19
Y199
T
S
K
Y
P
K
G
Y
F
V
Q
N
T
Y
F
Site 20
Y205
G
Y
F
V
Q
N
T
Y
F
D
F
F
N
Y
A
Site 21
S217
N
Y
A
G
L
Q
R
S
V
L
L
Y
T
T
P
Site 22
T223
R
S
V
L
L
Y
T
T
P
T
T
Y
I
D
D
Site 23
T232
T
T
Y
I
D
D
I
T
V
T
T
S
V
E
Q
Site 24
S236
D
D
I
T
V
T
T
S
V
E
Q
D
S
G
L
Site 25
S253
Y
Q
I
S
V
K
G
S
N
L
F
K
L
E
V
Site 26
T274
N
K
V
V
A
N
G
T
G
T
Q
G
Q
L
K
Site 27
Y291
G
V
S
L
W
W
P
Y
L
M
H
E
R
P
A
Site 28
Y299
L
M
H
E
R
P
A
Y
L
Y
S
L
E
V
Q
Site 29
Y301
H
E
R
P
A
Y
L
Y
S
L
E
V
Q
L
T
Site 30
S302
E
R
P
A
Y
L
Y
S
L
E
V
Q
L
T
A
Site 31
T308
Y
S
L
E
V
Q
L
T
A
Q
T
S
L
G
P
Site 32
S334
R
T
V
A
V
T
K
S
Q
F
L
I
N
G
K
Site 33
Y344
L
I
N
G
K
P
F
Y
F
H
G
V
N
K
H
Site 34
S384
G
A
N
A
F
R
T
S
H
Y
P
Y
A
E
E
Site 35
Y386
N
A
F
R
T
S
H
Y
P
Y
A
E
E
V
M
Site 36
Y388
F
R
T
S
H
Y
P
Y
A
E
E
V
M
Q
M
Site 37
S454
S
V
A
N
E
P
A
S
H
L
E
S
A
G
Y
Site 38
S458
E
P
A
S
H
L
E
S
A
G
Y
Y
L
K
M
Site 39
S472
M
V
I
A
H
T
K
S
L
D
P
S
R
P
V
Site 40
S476
H
T
K
S
L
D
P
S
R
P
V
T
F
V
S
Site 41
T480
L
D
P
S
R
P
V
T
F
V
S
N
S
N
Y
Site 42
S483
S
R
P
V
T
F
V
S
N
S
N
Y
A
A
D
Site 43
Y487
T
F
V
S
N
S
N
Y
A
A
D
K
G
A
P
Site 44
Y508
L
N
S
Y
Y
S
W
Y
H
D
Y
G
H
L
E
Site 45
Y511
Y
Y
S
W
Y
H
D
Y
G
H
L
E
L
I
Q
Site 46
Y532
F
E
N
W
Y
K
K
Y
Q
K
P
I
I
Q
S
Site 47
Y561
P
L
M
F
T
E
E
Y
Q
K
S
L
L
E
Q
Site 48
S564
F
T
E
E
Y
Q
K
S
L
L
E
Q
Y
H
L
Site 49
Y580
L
D
Q
K
R
R
K
Y
V
V
G
E
L
I
W
Site 50
S597
A
D
F
M
T
E
Q
S
P
T
R
V
L
G
N
Site 51
T599
F
M
T
E
Q
S
P
T
R
V
L
G
N
K
K
Site 52
S617
T
R
Q
R
Q
P
K
S
A
A
F
L
L
R
E
Site 53
Y626
A
F
L
L
R
E
R
Y
W
K
I
A
N
E
T
Site 54
Y635
K
I
A
N
E
T
R
Y
P
H
S
V
A
K
S
Site 55
S638
N
E
T
R
Y
P
H
S
V
A
K
S
Q
C
L
Site 56
S642
Y
P
H
S
V
A
K
S
Q
C
L
E
N
S
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation