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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HSP90AB1
Full Name:
Heat shock protein HSP 90-beta
Alias:
Heat shock 90kDa protein 1, beta; Heat shock protein 90kDa alpha (cytosolic) class B member 1; HS90B; HSP 84; HSP90-beta; HSPC2; HSPCB
Type:
Chaperone protein
Mass (Da):
83264
Number AA:
724
UniProt ID:
P08238
International Prot ID:
IPI00414676
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0042470
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0030911
GO:0030235
PhosphoSite+
KinaseNET
Biological Process:
GO:0032435
GO:0045429
GO:0006457
Phosida
TranscriptoNet
STRING
Kinexus Products
Heat shock protein HSP 90-beta pan-specific antibody AB-NN061-16#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN061-16#Heat shock protein HSP 90-beta pan-specific antibody AB-NN061-17#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN061-17#Heat shock protein HSP 90-beta pan-specific antibody AB-NN061-18#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN061-18#Heat shock protein HSP 90-beta pan-specific antibody AB-NN061-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN061-3#Heat shock protein HSP 90-beta pan-specific antibody AB-NN165#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN165#Heat shock protein HSP 90-beta pan-specific antibody AB-NN165-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN165-1#Heat shock protein HSP 90-beta Y484 phosphosite-specific antibody AB-PN520#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN520#Heat shock protein HSP 90-beta (K481-T487, human) pY484 phosphopeptide - Powder PE-04AFE99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AFE99#Heat shock protein HSP 90-beta (D252-E258, human) pS255 phosphopeptide - Powder PE-04ARA90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ARA90
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
H
G
E
E
E
V
E
T
F
A
F
Q
A
E
I
Site 2
Y33
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
Site 3
S45
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
Site 4
S48
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Site 5
Y56
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
Site 6
S58
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
L
Site 7
T60
K
I
R
Y
E
S
L
T
D
P
S
K
L
D
S
Site 8
S63
Y
E
S
L
T
D
P
S
K
L
D
S
G
K
E
Site 9
S67
T
D
P
S
K
L
D
S
G
K
E
L
K
I
D
Site 10
T85
N
P
Q
E
R
T
L
T
L
V
D
T
G
I
G
Site 11
T89
R
T
L
T
L
V
D
T
G
I
G
M
T
K
A
Site 12
T94
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
Site 13
T104
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
Site 14
S108
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
Site 15
S124
L
Q
A
G
A
D
I
S
M
I
G
Q
F
G
V
Site 16
Y155
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
Site 17
S159
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
Site 18
S164
W
E
S
S
A
G
G
S
F
T
V
R
A
D
H
Site 19
T166
S
S
A
G
G
S
F
T
V
R
A
D
H
G
E
Site 20
T179
G
E
P
I
G
R
G
T
K
V
I
L
H
L
K
Site 21
T190
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
Site 22
Y192
L
K
E
D
Q
T
E
Y
L
E
E
R
R
V
K
Site 23
S206
K
E
V
V
K
K
H
S
Q
F
I
G
Y
P
I
Site 24
Y211
K
H
S
Q
F
I
G
Y
P
I
T
L
Y
L
E
Site 25
T214
Q
F
I
G
Y
P
I
T
L
Y
L
E
K
E
R
Site 26
Y216
I
G
Y
P
I
T
L
Y
L
E
K
E
R
E
K
Site 27
S226
K
E
R
E
K
E
I
S
D
D
E
A
E
E
E
Site 28
S255
P
K
I
E
D
V
G
S
D
E
E
D
D
S
G
Heat shock protein HSP 90-beta (D252-E258, human) pS255 phosphopeptide - Powder PE-04ARA90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ARA90
Site 29
S261
G
S
D
E
E
D
D
S
G
K
D
K
K
K
K
Site 30
T269
G
K
D
K
K
K
K
T
K
K
I
K
E
K
Y
Site 31
Y276
T
K
K
I
K
E
K
Y
I
D
Q
E
E
L
N
Site 32
T285
D
Q
E
E
L
N
K
T
K
P
I
W
T
R
N
Site 33
T297
T
R
N
P
D
D
I
T
Q
E
E
Y
G
E
F
Site 34
Y301
D
D
I
T
Q
E
E
Y
G
E
F
Y
K
S
L
Site 35
Y305
Q
E
E
Y
G
E
F
Y
K
S
L
T
N
D
W
Site 36
S307
E
Y
G
E
F
Y
K
S
L
T
N
D
W
E
D
Site 37
T309
G
E
F
Y
K
S
L
T
N
D
W
E
D
H
L
Site 38
Y356
K
K
N
N
I
K
L
Y
V
R
R
V
F
I
M
Site 39
S365
R
R
V
F
I
M
D
S
C
D
E
L
I
P
E
Site 40
S391
E
D
L
P
L
N
I
S
R
E
M
L
Q
Q
S
Site 41
S398
S
R
E
M
L
Q
Q
S
K
I
L
K
V
I
R
Site 42
Y430
K
E
N
Y
K
K
F
Y
E
A
F
S
K
N
L
Site 43
S434
K
K
F
Y
E
A
F
S
K
N
L
K
L
G
I
Site 44
S445
K
L
G
I
H
E
D
S
T
N
R
R
R
L
S
Site 45
T446
L
G
I
H
E
D
S
T
N
R
R
R
L
S
E
Site 46
S452
S
T
N
R
R
R
L
S
E
L
L
R
Y
H
T
Site 47
Y457
R
L
S
E
L
L
R
Y
H
T
S
Q
S
G
D
Site 48
T459
S
E
L
L
R
Y
H
T
S
Q
S
G
D
E
M
Site 49
S460
E
L
L
R
Y
H
T
S
Q
S
G
D
E
M
T
Site 50
S462
L
R
Y
H
T
S
Q
S
G
D
E
M
T
S
L
Site 51
S468
Q
S
G
D
E
M
T
S
L
S
E
Y
V
S
R
Site 52
S470
G
D
E
M
T
S
L
S
E
Y
V
S
R
M
K
Site 53
Y472
E
M
T
S
L
S
E
Y
V
S
R
M
K
E
T
Site 54
S474
T
S
L
S
E
Y
V
S
R
M
K
E
T
Q
K
Site 55
S482
R
M
K
E
T
Q
K
S
I
Y
Y
I
T
G
E
Site 56
Y484
K
E
T
Q
K
S
I
Y
Y
I
T
G
E
S
K
Heat shock protein HSP 90-beta Y484 phosphosite-specific antibody AB-PN520#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN520#Heat shock protein HSP 90-beta (K481-T487, human) pY484 phosphopeptide - Powder PE-04AFE99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AFE99
Site 57
Y485
E
T
Q
K
S
I
Y
Y
I
T
G
E
S
K
E
Site 58
S497
S
K
E
Q
V
A
N
S
A
F
V
E
R
V
R
Site 59
Y512
K
R
G
F
E
V
V
Y
M
T
E
P
I
D
E
Site 60
T514
G
F
E
V
V
Y
M
T
E
P
I
D
E
Y
C
Site 61
Y520
M
T
E
P
I
D
E
Y
C
V
Q
Q
L
K
E
Site 62
S532
L
K
E
F
D
G
K
S
L
V
S
V
T
K
E
Site 63
S535
F
D
G
K
S
L
V
S
V
T
K
E
G
L
E
Site 64
T537
G
K
S
L
V
S
V
T
K
E
G
L
E
L
P
Site 65
T579
D
K
K
V
E
K
V
T
I
S
N
R
L
V
S
Site 66
S581
K
V
E
K
V
T
I
S
N
R
L
V
S
S
P
Site 67
S586
T
I
S
N
R
L
V
S
S
P
C
C
I
V
T
Site 68
S587
I
S
N
R
L
V
S
S
P
C
C
I
V
T
S
Site 69
S594
S
P
C
C
I
V
T
S
T
Y
G
W
T
A
N
Site 70
T595
P
C
C
I
V
T
S
T
Y
G
W
T
A
N
M
Site 71
Y596
C
C
I
V
T
S
T
Y
G
W
T
A
N
M
E
Site 72
S615
A
Q
A
L
R
D
N
S
T
M
G
Y
M
M
A
Site 73
T616
Q
A
L
R
D
N
S
T
M
G
Y
M
M
A
K
Site 74
Y619
R
D
N
S
T
M
G
Y
M
M
A
K
K
H
L
Site 75
S669
A
L
L
S
S
G
F
S
L
E
D
P
Q
T
H
Site 76
T675
F
S
L
E
D
P
Q
T
H
S
N
R
I
Y
R
Site 77
Y681
Q
T
H
S
N
R
I
Y
R
M
I
K
L
G
L
Site 78
S718
L
E
G
D
E
D
A
S
R
M
E
E
V
D
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation