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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ASNS
Full Name:
Asparagine synthetase [glutamine-hydrolyzing]
Alias:
Asparagine synthetase; Asparagine synthetase glutamine-hydrolyzing; Cell cycle control protein TS11; EC 6.3.5.4; Glutamine-dependent asparagine synthetase; TS11; TS11 cell cycle control
Type:
Amino Acid Metabolism - alanine, aspartate and glutamate; Cell cycle regulation; EC 6.3.5.4; Ligase; Energy Metabolism - nitrogen
Mass (Da):
64370
Number AA:
561
UniProt ID:
P08243
International Prot ID:
IPI00554777
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004066
PhosphoSite+
KinaseNET
Biological Process:
GO:0006529
GO:0042149
GO:0006541
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y40
R
F
E
N
V
N
G
Y
T
N
C
C
F
G
F
Site 2
Y67
Q
P
I
R
V
K
K
Y
P
Y
L
W
L
C
Y
Site 3
Y69
I
R
V
K
K
Y
P
Y
L
W
L
C
Y
N
G
Site 4
Y79
L
C
Y
N
G
E
I
Y
N
H
K
K
M
Q
Q
Site 5
Y92
Q
Q
H
F
E
F
E
Y
Q
T
K
V
D
G
E
Site 6
Y105
G
E
I
I
L
H
L
Y
D
K
G
G
I
E
Q
Site 7
T166
S
E
A
K
G
L
V
T
L
K
H
S
A
T
P
Site 8
T172
V
T
L
K
H
S
A
T
P
F
L
K
V
E
P
Site 9
S198
K
P
N
G
K
V
A
S
V
E
M
V
K
Y
H
Site 10
Y204
A
S
V
E
M
V
K
Y
H
H
C
R
D
V
P
Site 11
Y216
D
V
P
L
H
A
L
Y
D
N
V
E
K
L
F
Site 12
T230
F
P
G
F
E
I
E
T
V
K
N
N
L
R
I
Site 13
T249
A
V
K
K
R
L
M
T
D
R
R
I
G
C
L
Site 14
S258
R
R
I
G
C
L
L
S
G
G
L
D
S
S
L
Site 15
T285
Q
V
Q
Y
P
L
Q
T
F
A
I
G
M
E
D
Site 16
Y311
D
H
I
G
S
E
H
Y
E
V
L
F
N
S
E
Site 17
T337
S
L
E
T
Y
D
I
T
T
V
R
A
S
V
G
Site 18
S342
D
I
T
T
V
R
A
S
V
G
M
Y
L
I
S
Site 19
Y351
G
M
Y
L
I
S
K
Y
I
R
K
N
T
D
S
Site 20
T356
S
K
Y
I
R
K
N
T
D
S
V
V
I
F
S
Site 21
S358
Y
I
R
K
N
T
D
S
V
V
I
F
S
G
E
Site 22
S363
T
D
S
V
V
I
F
S
G
E
G
S
D
E
L
Site 23
S367
V
I
F
S
G
E
G
S
D
E
L
T
Q
G
Y
Site 24
T371
G
E
G
S
D
E
L
T
Q
G
Y
I
Y
F
H
Site 25
Y376
E
L
T
Q
G
Y
I
Y
F
H
K
A
P
S
P
Site 26
S382
I
Y
F
H
K
A
P
S
P
E
K
A
E
E
E
Site 27
S390
P
E
K
A
E
E
E
S
E
R
L
L
R
E
L
Site 28
T408
D
V
L
R
A
D
R
T
T
A
A
H
G
L
E
Site 29
T409
V
L
R
A
D
R
T
T
A
A
H
G
L
E
L
Site 30
S426
P
F
L
D
H
R
F
S
S
Y
Y
L
S
L
P
Site 31
S427
F
L
D
H
R
F
S
S
Y
Y
L
S
L
P
P
Site 32
Y428
L
D
H
R
F
S
S
Y
Y
L
S
L
P
P
E
Site 33
Y429
D
H
R
F
S
S
Y
Y
L
S
L
P
P
E
M
Site 34
S431
R
F
S
S
Y
Y
L
S
L
P
P
E
M
R
I
Site 35
T451
E
K
H
L
L
R
E
T
F
E
D
S
N
L
I
Site 36
T475
E
A
F
S
D
G
I
T
S
V
K
N
S
W
F
Site 37
S476
A
F
S
D
G
I
T
S
V
K
N
S
W
F
K
Site 38
S480
G
I
T
S
V
K
N
S
W
F
K
I
L
Q
E
Site 39
Y488
W
F
K
I
L
Q
E
Y
V
E
H
Q
V
D
D
Site 40
T509
A
Q
K
F
P
F
N
T
P
K
T
K
E
G
Y
Site 41
T512
F
P
F
N
T
P
K
T
K
E
G
Y
Y
Y
R
Site 42
Y517
P
K
T
K
E
G
Y
Y
Y
R
Q
V
F
E
R
Site 43
Y518
K
T
K
E
G
Y
Y
Y
R
Q
V
F
E
R
H
Site 44
Y526
R
Q
V
F
E
R
H
Y
P
G
R
A
D
W
L
Site 45
T553
D
P
S
A
R
T
L
T
H
Y
K
S
A
V
K
Site 46
Y555
S
A
R
T
L
T
H
Y
K
S
A
V
K
A
_
Site 47
S557
R
T
L
T
H
Y
K
S
A
V
K
A
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation